PMID- 26165064
OWN - NLM
STAT- MEDLINE
DCOM- 20150918
LR  - 20181202
IS  - 0047-1852 (Print)
IS  - 0047-1852 (Linking)
VI  - 73
IP  - 7
DP  - 2015 Jul
TI  - [Pathophysiology and treatment of reflux esophagitis].
PG  - 1098-102
AB  - Reflux esophagitis (RE) is characterized by excessive esophageal acid exposure. 
      The number of acid reflux episodes, the way acid comes up after reflux and the 
      delay of acid bolus clearance cause excessive esophageal acid exposure. Transient 
      lower esophageal sphincter relaxation (TLESR) is the major mechanism of acid 
      reflux in both healthy subjects (HS) and in patients with RE, but there is no 
      difference in the rate of TLESRs or in the rate of acid reflux during TLESRs 
      above the LES between HS and patients with RE. In patients with severe RE, 
      refluxed acid above the LES rises more easily to the proximal esophagus but it 
      does not clear easily from the esophagus when compared with HS. To cure RE, it is 
      necessary to normalize excessive esophageal acid exposure. In GERD guideline in 
      Japanese Society of Gastroenterology, standard dose proton pump inhibitor (PPI) 
      is recommended as the first-line therapy. The response to a standard dose of PPI 
      in patients with mild RE is 90-95%, and that in patients with severe RE is 
      80-85%. In case that standard dose of PPI is not effective, it is possible that 
      the change to other PPI, the change of administration method (before a meal) and 
      double-dose PPI therapy are effective.
FAU - Iwakiri, Katsuhiko
AU  - Iwakiri K
FAU - Kawami, Noriyuki
AU  - Kawami N
LA  - jpn
PT  - Journal Article
PL  - Japan
TA  - Nihon Rinsho
JT  - Nihon rinsho. Japanese journal of clinical medicine
JID - 0420546
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - Esophagitis, Peptic/drug therapy/*physiopathology
MH  - Gastric Acid/metabolism
MH  - Humans
MH  - Medicine, Chinese Traditional
MH  - Muscle Relaxation
MH  - Proton Pump Inhibitors/therapeutic use
EDAT- 2015/07/15 06:00
MHDA- 2015/09/19 06:00
CRDT- 2015/07/14 06:00
PHST- 2015/07/14 06:00 [entrez]
PHST- 2015/07/15 06:00 [pubmed]
PHST- 2015/09/19 06:00 [medline]
PST - ppublish
SO  - Nihon Rinsho. 2015 Jul;73(7):1098-102.