PMID- 26165073 OWN - NLM STAT- MEDLINE DCOM- 20150918 LR - 20150713 IS - 0047-1852 (Print) IS - 0047-1852 (Linking) VI - 73 IP - 7 DP - 2015 Jul TI - [Effect of H2-receptor antagonist and proton pomp inhibitor on the treatment of acid-related disease]. PG - 1159-62 AB - We summarized proton pump inhibitors(PPI) and histamine H2-receptor antagonist (H2B) with reference to acid-related disease. The both drugs act process of gastric acid secretion in parietal cell of stomach. Inhibition of H2B is reversible, but that of PPI is irreversible, so period of acting in PPI is longer than that in H2B. PPI is more effective than H2B in treatment of acid-related disease. Especially PPI is recommended the first choice in GERD and NSAID ulcer. FAU - Kawai, Takashi AU - Kawai T FAU - Yagi, Kenji AU - Yagi K FAU - Moriyasu, Fuminori AU - Moriyasu F LA - jpn PT - English Abstract PT - Journal Article PL - Japan TA - Nihon Rinsho JT - Nihon rinsho. Japanese journal of clinical medicine JID - 0420546 RN - 0 (Histamine H2 Antagonists) RN - 0 (Proton Pump Inhibitors) SB - IM MH - Duodenal Ulcer/drug therapy MH - Gastroesophageal Reflux/*drug therapy MH - Gastrointestinal Hemorrhage/drug therapy MH - Histamine H2 Antagonists/*therapeutic use MH - Humans MH - Proton Pump Inhibitors/*therapeutic use MH - Stomach Ulcer/drug therapy EDAT- 2015/07/15 06:00 MHDA- 2015/09/19 06:00 CRDT- 2015/07/14 06:00 PHST- 2015/07/14 06:00 [entrez] PHST- 2015/07/15 06:00 [pubmed] PHST- 2015/09/19 06:00 [medline] PST - ppublish SO - Nihon Rinsho. 2015 Jul;73(7):1159-62.