PMID- 26165080
OWN - NLM
STAT- MEDLINE
DCOM- 20150918
LR  - 20220317
IS  - 0047-1852 (Print)
IS  - 0047-1852 (Linking)
VI  - 73
IP  - 7
DP  - 2015 Jul
TI  - [Pathophysiology and Treatment of PPI-resistant NERD].
PG  - 1197-201
AB  - Only about 50% of patients with non-erosive reflux disease (NERD) respond to 
      standard doses of proton pump inhibitors (PPI). Various mechanisms have been 
      proposed to explain PPI failure. Visceral hypersensitivity plays a basic role in 
      the pathogenesis of NERD. Causes of persistent symptoms have been determined in 
      60% of patients with PPI-resistant NERD, including non-acid reflux (35-40%), acid 
      reflux (10-15%), esophageal motility disorders (10%) and eosinophilic esophagitis 
      (2%). Treatment based on these causes has been shown to improve patient symptoms. 
      The causes of symptoms in the remaining 40% of patients, however, remain unknown, 
      and these patients are often diagnosed with functional heartburn. Studies are 
      needed to clarify the pathophysiologic mechanisms underlying functional heartburn 
      in these patients.
FAU - Kawami, Noriyuki
AU  - Kawami N
FAU - Iwakiri, Katsuhiko
AU  - Iwakiri K
FAU - Sakamoto, Choitsu
AU  - Sakamoto C
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PL  - Japan
TA  - Nihon Rinsho
JT  - Nihon rinsho. Japanese journal of clinical medicine
JID - 0420546
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - Eosinophilic Esophagitis/drug therapy
MH  - Esophageal Motility Disorders/physiopathology
MH  - Esophageal pH Monitoring
MH  - Gastroesophageal Reflux/*drug therapy/*physiopathology
MH  - Humans
MH  - Proton Pump Inhibitors/*therapeutic use
EDAT- 2015/07/15 06:00
MHDA- 2015/09/19 06:00
CRDT- 2015/07/14 06:00
PHST- 2015/07/14 06:00 [entrez]
PHST- 2015/07/15 06:00 [pubmed]
PHST- 2015/09/19 06:00 [medline]
PST - ppublish
SO  - Nihon Rinsho. 2015 Jul;73(7):1197-201.