PMID- 26165748
OWN - NLM
STAT- MEDLINE
DCOM- 20160720
LR  - 20240324
IS  - 1469-8978 (Electronic)
IS  - 0033-2917 (Print)
IS  - 0033-2917 (Linking)
VI  - 45
IP  - 15
DP  - 2015 Nov
TI  - Minimal clinically important difference on the Beck Depression Inventory--II 
      according to the patient's perspective.
PG  - 3269-79
LID - 10.1017/S0033291715001270 [doi]
AB  - BACKGROUND: The Beck Depression Inventory, 2nd edition (BDI-II) is widely used in 
      research on depression. However, the minimal clinically important difference 
      (MCID) is unknown. MCID can be estimated in several ways. Here we take a 
      patient-centred approach, anchoring the change on the BDI-II to the patient's 
      global report of improvement. METHOD: We used data collected (n = 1039) from 
      three randomized controlled trials for the management of depression. Improvement 
      on a 'global rating of change' question was compared with changes in BDI-II 
      scores using general linear modelling to explore baseline dependency, assessing 
      whether MCID is best measured in absolute terms (i.e. difference) or as percent 
      reduction in scores from baseline (i.e. ratio), and receiver operator 
      characteristics (ROC) to estimate MCID according to the optimal threshold above 
      which individuals report feeling 'better'. RESULTS: Improvement in BDI-II scores 
      associated with reporting feeling 'better' depended on initial depression 
      severity, and statistical modelling indicated that MCID is best measured on a 
      ratio scale as a percentage reduction of score. We estimated a MCID of a 17.5% 
      reduction in scores from baseline from ROC analyses. The corresponding estimate 
      for individuals with longer duration depression who had not responded to 
      antidepressants was higher at 32%. CONCLUSIONS: MCID on the BDI-II is dependent 
      on baseline severity, is best measured on a ratio scale, and the MCID for 
      treatment-resistant depression is larger than that for more typical depression. 
      This has important implications for clinical trials and practice.
FAU - Button, K S
AU  - Button KS
AD  - School of Social and Community Medicine,University of Bristol,Bristol,UK.
FAU - Kounali, D
AU  - Kounali D
AD  - School of Social and Community Medicine,University of Bristol,Bristol,UK.
FAU - Thomas, L
AU  - Thomas L
AD  - School of Social and Community Medicine,University of Bristol,Bristol,UK.
FAU - Wiles, N J
AU  - Wiles NJ
AD  - School of Social and Community Medicine,University of Bristol,Bristol,UK.
FAU - Peters, T J
AU  - Peters TJ
AD  - School of Clinical Sciences,University of Bristol,Bristol,UK.
FAU - Welton, N J
AU  - Welton NJ
AD  - School of Social and Community Medicine,University of Bristol,Bristol,UK.
FAU - Ades, A E
AU  - Ades AE
AD  - School of Social and Community Medicine,University of Bristol,Bristol,UK.
FAU - Lewis, G
AU  - Lewis G
AD  - Division of Psychiatry,University College London,London,UK.
LA  - eng
GR  - G0802413/MRC_/Medical Research Council/United Kingdom
GR  - MC_U145079307/MRC_/Medical Research Council/United Kingdom
GR  - MR/K025643/1/MRC_/Medical Research Council/United Kingdom
GR  - RP-PG-0610-10048/DH_/Department of Health/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150713
PL  - England
TA  - Psychol Med
JT  - Psychological medicine
JID - 1254142
SB  - IM
MH  - Adult
MH  - Depression/*diagnosis/therapy
MH  - Depressive Disorder/*diagnosis/therapy
MH  - Depressive Disorder, Treatment-Resistant/diagnosis/therapy
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Outcome Assessment, Health Care/*standards
MH  - Psychiatric Status Rating Scales/*standards
MH  - Psychometrics/*standards
MH  - Randomized Controlled Trials as Topic
MH  - *Severity of Illness Index
PMC - PMC4611356
OTO - NOTNLM
OT  - 2nd edition (BDI-II)
OT  - Beck Depression Inventory
OT  - depression
OT  - minimal clinically important difference
OT  - outcome assessment
OT  - primary care
EDAT- 2015/07/15 06:00
MHDA- 2016/07/21 06:00
PMCR- 2015/10/20
CRDT- 2015/07/14 06:00
PHST- 2015/07/14 06:00 [entrez]
PHST- 2015/07/15 06:00 [pubmed]
PHST- 2016/07/21 06:00 [medline]
PHST- 2015/10/20 00:00 [pmc-release]
AID - S0033291715001270 [pii]
AID - 00127 [pii]
AID - 10.1017/S0033291715001270 [doi]
PST - ppublish
SO  - Psychol Med. 2015 Nov;45(15):3269-79. doi: 10.1017/S0033291715001270. Epub 2015 
      Jul 13.