PMID- 26165958 OWN - NLM STAT- MEDLINE DCOM- 20160401 LR - 20221207 IS - 1872-7123 (Electronic) IS - 0165-1781 (Linking) VI - 228 IP - 3 DP - 2015 Aug 30 TI - Screening schizotypal personality disorder for detection of clinical high risk of psychosis in Chinese mental health services. PG - 664-70 LID - S0165-1781(15)00320-0 [pii] LID - 10.1016/j.psychres.2015.04.049 [doi] AB - Schizotypal personality disorder (SPD) is viewed as a marker of prodromal psychosis. However, information regarding genetic risk (e.g. SPD) is often overlooked in the identification process. This study assessed whether SPD screening questionnaire help the prodromal psychosis (also widely applied "clinical high risk" (CHR) for clinical sample) detection in Chinese mental health service. This work also examined whether SPD had higher frequency in genetic risk population and CHR subjects. Two wave studies concerning the SPD identification was used for analysis. Wave 1 survey: 3075 subjects were assessed by Personality Diagnostic Questionnaire for SPD (PDQ-SPD) and Structured Clinical Interview for DSM-IV Axis II (SCID-II). Wave 2 survey: 2113 subjects screened with the prodromal questionnaire -brief version (PQ-B), PDQ-SPD, and interviewed by Structured Interview for Prodromal Symptoms (SIPS). Subjects with family history of mental disorders or with psychosis reported significantly higher scores in SPD. Receiver operating characteristic curves suggested that PDQ-SPD had moderate sensitivity and specificity for identifying CHR subjects. There was significant higher on SPD features in subjects with early stage (Course less than 1 year) of psychosis. Identifying SPD may be useful in early detection of psychosis especially in detecting the genetic risk syndromes and can be integrated with existing prodromal screen tools to improve its efficiency. CI - Copyright (c) 2015 Elsevier Ireland Ltd. All rights reserved. FAU - Zhang, TianHong AU - Zhang T AD - Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Psychotic Disorders, Shanghai 200030, PR China. FAU - Li, HuiJun AU - Li H AD - Florida A & M University, Department of Psychology, Tallahassee, FL 32307, USA. FAU - Tang, YingYing AU - Tang Y AD - Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Psychotic Disorders, Shanghai 200030, PR China. FAU - Li, Hui AU - Li H AD - Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Psychotic Disorders, Shanghai 200030, PR China. FAU - Zheng, LiNa AU - Zheng L AD - Liaocheng People׳s Hospital, Shandong, PR China. FAU - Guo, Qian AU - Guo Q AD - Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Psychotic Disorders, Shanghai 200030, PR China. FAU - Zhao, ShanShan AU - Zhao S AD - Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Psychotic Disorders, Shanghai 200030, PR China. FAU - Zhuo, KaiMing AU - Zhuo K AD - Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Psychotic Disorders, Shanghai 200030, PR China. FAU - Qian, ZhenYing AU - Qian Z AD - Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Psychotic Disorders, Shanghai 200030, PR China. FAU - Wang, LanLan AU - Wang L AD - Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Psychotic Disorders, Shanghai 200030, PR China. FAU - Dai, YunFei AU - Dai Y AD - Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Psychotic Disorders, Shanghai 200030, PR China. FAU - Chow, Annabelle AU - Chow A AD - Changi General Hospital, Department of Psychological Medicine, Singapore. FAU - Li, ChunBo AU - Li C AD - Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Psychotic Disorders, Shanghai 200030, PR China. FAU - Jiang, KaiDa AU - Jiang K AD - Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Psychotic Disorders, Shanghai 200030, PR China. FAU - Wang, JiJun AU - Wang J AD - Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Psychotic Disorders, Shanghai 200030, PR China. Electronic address: jijunwang27@163.com. FAU - Xiao, ZePing AU - Xiao Z AD - Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Psychotic Disorders, Shanghai 200030, PR China. Electronic address: xiao_zeping@126.com. LA - eng GR - 1R21MH093294-01A1/MH/NIMH NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't DEP - 20150614 PL - Ireland TA - Psychiatry Res JT - Psychiatry research JID - 7911385 SB - IM MH - Adult MH - *Asian People/psychology MH - Cross-Sectional Studies MH - Diagnostic and Statistical Manual of Mental Disorders MH - Early Diagnosis MH - Female MH - Humans MH - Male MH - Mental Health Services/*standards MH - Middle Aged MH - Psychotic Disorders/*diagnosis/*epidemiology/psychology MH - Risk Factors MH - Schizotypal Personality Disorder/*diagnosis/*epidemiology/psychology MH - Surveys and Questionnaires MH - Young Adult OTO - NOTNLM OT - Clinical high risk OT - Early detection OT - Prodromal OT - Psychosis OT - Schizotypal personality disorder OT - Screening OT - Self-report instrument EDAT- 2015/07/15 06:00 MHDA- 2016/04/02 06:00 CRDT- 2015/07/14 06:00 PHST- 2014/05/21 00:00 [received] PHST- 2015/03/13 00:00 [revised] PHST- 2015/04/20 00:00 [accepted] PHST- 2015/07/14 06:00 [entrez] PHST- 2015/07/15 06:00 [pubmed] PHST- 2016/04/02 06:00 [medline] AID - S0165-1781(15)00320-0 [pii] AID - 10.1016/j.psychres.2015.04.049 [doi] PST - ppublish SO - Psychiatry Res. 2015 Aug 30;228(3):664-70. doi: 10.1016/j.psychres.2015.04.049. Epub 2015 Jun 14.