PMID- 26166607
OWN - NLM
STAT- MEDLINE
DCOM- 20160606
LR  - 20190728
IS  - 1873-4286 (Electronic)
IS  - 1381-6128 (Linking)
VI  - 21
IP  - 25
DP  - 2015
TI  - Impact of Metformin on Male Reproduction.
PG  - 3621-33
AB  - Male infertility has been increasing over the last decades being nowadays a 
      pressing health problem. Diabetes mellitus (DM) can contribute directly or 
      indirectly to male infertility due to an abnormal spermatogenesis, which results 
      in a decreased sperm quality. Type 2 Diabetes mellitus (T2DM) is responsible for 
      the vast majority of DM cases, being frequently treated with oral antidiabetic 
      drugs. Metformin is the most cost-effective therapy for the treatment of T2DM. 
      This biguanide is an oral insulin-sensitizing agent capable of increasing insulin 
      sensitivity and decreasing plasma fasting insulin levels. The main metabolic 
      action of this drug occurs in the liver. However, it has been shown that 
      metformin acts on a variety of organs including the male reproductive system. 
      With the rising numbers of diabetic individuals among younger populations, there 
      is an increase in the consumption of metformin in individuals of this age group. 
      As a result, it is important to discuss the role of metformin in male fertility. 
      This review presents the most recent data available from studies on the effects 
      of metformin on male reproductive system. Together with the discussion of these 
      effects, their significance to male fertility is also debated.
FAU - Ferreira, Carolina
AU  - Ferreira C
FAU - Sousa, Mario
AU  - Sousa M
FAU - Rabaca, Ana
AU  - Rabaca A
FAU - Oliveira, Pedro F
AU  - Oliveira PF
FAU - Alves, Marco G
AU  - Alves MG
FAU - Sa, Rosalia
AU  - Sa R
AD  - Department of Microscopy, Laboratory of Cell Biology, ICBAS-UP, UMIB, Rua Jorge 
      Viterbo Ferreira 228, Building 1, Floor 2, Room 03, 4050-313 Porto, Portugal. 
      rmsa@icbas.up.pt.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United Arab Emirates
TA  - Curr Pharm Des
JT  - Current pharmaceutical design
JID - 9602487
RN  - 0 (Hypoglycemic Agents)
RN  - 9100L32L2N (Metformin)
SB  - IM
MH  - Animals
MH  - Diabetes Mellitus, Type 2/*drug therapy/metabolism
MH  - Humans
MH  - Hypoglycemic Agents/administration & dosage/*pharmacology/therapeutic use
MH  - Infertility, Male/*etiology/metabolism/prevention & control
MH  - Male
MH  - Metformin/adverse effects/*pharmacology/therapeutic use
MH  - Reproduction/*drug effects
MH  - Sertoli Cells/drug effects/metabolism
MH  - Spermatogenesis/drug effects
EDAT- 2015/07/15 06:00
MHDA- 2016/06/09 06:00
CRDT- 2015/07/14 06:00
PHST- 2015/05/23 00:00 [received]
PHST- 2015/07/08 00:00 [accepted]
PHST- 2015/07/14 06:00 [entrez]
PHST- 2015/07/15 06:00 [pubmed]
PHST- 2016/06/09 06:00 [medline]
AID - CPD-EPUB-68757 [pii]
AID - 10.2174/1381612821666150710150041 [doi]
PST - ppublish
SO  - Curr Pharm Des. 2015;21(25):3621-33. doi: 10.2174/1381612821666150710150041.