PMID- 26167174
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150713
LR  - 20200930
IS  - 1687-6121 (Print)
IS  - 1687-630X (Electronic)
IS  - 1687-6121 (Linking)
VI  - 2015
DP  - 2015
TI  - Interferon Treatment of Hepatitis C Reinfection after Liver Transplantation: A 
      Meta-Analysis.
PG  - 206302
LID - 10.1155/2015/206302 [doi]
LID - 206302
AB  - Background. Graft reinfection with hepatitis C (HCV) after liver transplantation 
      is a significant problem in transplant hepatology. This meta-analysis was 
      performed to compare the effectiveness and risk of adverse events of 
      interferon-based therapy with no treatment after liver transplantation. Methods. 
      We searched electronic databases up to July 31, 2013, to obtain relevant research 
      reports that satisfied the inclusion criteria. Meta-analyses were done on 
      randomized controlled trials (RCTs) and nonrandomized trials. Results. A 
      meta-analysis was performed on 2 RCTs and 2 cohort studies comprising a total of 
      326 patients (171 of whom accepted interferon-based antiviral therapy). The 
      treatment group was found to have higher virological response (VR) rates than 
      controls at 12, 24, 48, and 72 weeks. Patients in the antiviral group had higher 
      sustained virological response (SVR) rates and lower mean alanine 
      aminotransferase levels relative to controls at 48 weeks, but more total serious 
      adverse events (AEs) than controls. Conclusions. Interferon-based treatment has 
      some efficacy in the treatment of HCV graft reinfection following liver 
      transplantation.
FAU - Chen, Yaqin
AU  - Chen Y
AD  - Department of Infectious Diseases, Institute for Viral Hepatitis, Key Laboratory 
      of Molecular Biology for Infectious Diseases, The Second Affiliated Hospital of 
      Chongqing Medical University, Chongqing 400010, China.
FAU - Wu, Gang
AU  - Wu G
AD  - Department of Infectious Diseases, The Affiliated Hospital of Luzhou Medical 
      College, Luzhou 646000, China.
FAU - Zhang, Hongmin
AU  - Zhang H
AD  - Department of Infectious Diseases, Institute for Viral Hepatitis, Key Laboratory 
      of Molecular Biology for Infectious Diseases, The Second Affiliated Hospital of 
      Chongqing Medical University, Chongqing 400010, China.
FAU - Xu, Hua
AU  - Xu H
AD  - Department of Infectious Diseases, Institute for Viral Hepatitis, Key Laboratory 
      of Molecular Biology for Infectious Diseases, The Second Affiliated Hospital of 
      Chongqing Medical University, Chongqing 400010, China.
FAU - Li, Hong
AU  - Li H
AD  - Department of Infectious Diseases, Institute for Viral Hepatitis, Key Laboratory 
      of Molecular Biology for Infectious Diseases, The Second Affiliated Hospital of 
      Chongqing Medical University, Chongqing 400010, China.
FAU - Chen, Ling
AU  - Chen L
AD  - Department of Infectious Diseases, Institute for Viral Hepatitis, Key Laboratory 
      of Molecular Biology for Infectious Diseases, The Second Affiliated Hospital of 
      Chongqing Medical University, Chongqing 400010, China.
FAU - Yang, Yixuan
AU  - Yang Y
AD  - Department of Infectious Diseases, Institute for Viral Hepatitis, Key Laboratory 
      of Molecular Biology for Infectious Diseases, The Second Affiliated Hospital of 
      Chongqing Medical University, Chongqing 400010, China.
FAU - Hu, Peng
AU  - Hu P
AD  - Department of Infectious Diseases, Institute for Viral Hepatitis, Key Laboratory 
      of Molecular Biology for Infectious Diseases, The Second Affiliated Hospital of 
      Chongqing Medical University, Chongqing 400010, China.
FAU - Zhang, Dazhi
AU  - Zhang D
AD  - Department of Infectious Diseases, Institute for Viral Hepatitis, Key Laboratory 
      of Molecular Biology for Infectious Diseases, The Second Affiliated Hospital of 
      Chongqing Medical University, Chongqing 400010, China.
FAU - Ren, Hong
AU  - Ren H
AD  - Department of Infectious Diseases, Institute for Viral Hepatitis, Key Laboratory 
      of Molecular Biology for Infectious Diseases, The Second Affiliated Hospital of 
      Chongqing Medical University, Chongqing 400010, China.
FAU - Hu, Huaidong
AU  - Hu H
AD  - Department of Infectious Diseases, Institute for Viral Hepatitis, Key Laboratory 
      of Molecular Biology for Infectious Diseases, The Second Affiliated Hospital of 
      Chongqing Medical University, Chongqing 400010, China.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20150616
PL  - Egypt
TA  - Gastroenterol Res Pract
JT  - Gastroenterology research and practice
JID - 101475557
PMC - PMC4488578
EDAT- 2015/07/15 06:00
MHDA- 2015/07/15 06:01
PMCR- 2015/06/16
CRDT- 2015/07/14 06:00
PHST- 2014/12/16 00:00 [received]
PHST- 2015/05/31 00:00 [revised]
PHST- 2015/06/04 00:00 [accepted]
PHST- 2015/07/14 06:00 [entrez]
PHST- 2015/07/15 06:00 [pubmed]
PHST- 2015/07/15 06:01 [medline]
PHST- 2015/06/16 00:00 [pmc-release]
AID - 10.1155/2015/206302 [doi]
PST - ppublish
SO  - Gastroenterol Res Pract. 2015;2015:206302. doi: 10.1155/2015/206302. Epub 2015 
      Jun 16.