PMID- 26167296
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150713
LR  - 20201001
IS  - 2090-0104 (Print)
IS  - 2090-0112 (Electronic)
IS  - 2090-0112 (Linking)
VI  - 2015
DP  - 2015
TI  - The Effects of Hyperhydrating Supplements Containing Creatine and Glucose on 
      Plasma Lipids and Insulin Sensitivity in Endurance-Trained Athletes.
PG  - 352458
LID - 10.1155/2015/352458 [doi]
LID - 352458
AB  - The addition of carbohydrate (CHO) in the form of simple sugars to creatine (Cr) 
      supplements is central. The study aimed to determine whether ingestion of glucose 
      (Glu) simultaneously with Cr and glycerol (Cr/Gly) supplement is detrimental to 
      plasma lipids of endurance-trained individuals and find out whether modification 
      arising can be attenuated by replacing part of the Glu with alpha lipoic acid 
      (Ala). Twenty-two endurance-trained cyclists were randomized to receive 
      Cr/Gly/Glu (11.4 g Cr-H2O, 1 g Gly/kg BM, and 150 g Glu) or Cr/Gly/Glu/Ala 
      (11.4 g Cr-H2O, 1 g Gly/kg BM, 100 g Glu, and 1 g Ala) for 7 days. Fasting 
      concentration of TAG increased significantly (P < 0.01) after supplementation 
      with Cr/Gly/Glu (before: 0.9 +/- 0.2 mmol/L; after: 1.3 +/- 0.4 mmol/L) and 
      Cr/Gly/Glu/Ala (before: 0.8 +/- 0.2 mmol/L; after: 1.2 +/- 0.5 mmol/L) but changes 
      were not different between the groups. Supplementation significantly (P < 0.05) 
      increased the TAG to HDL-cholesterol ratio but had no effect on fasting 
      concentration of total, HDL-, and LDL-cholesterol and insulin resistance. Thus, 
      addition of Glu to Cr containing supplements enhances plasma TAG concentration 
      and the TAG to HDL-cholesterol ratio and this enhancement cannot be attenuated by 
      partial replacement of Glu with Ala.
FAU - Polyviou, Thelma P
AU  - Polyviou TP
AD  - Human Nutrition, School of Medicine, College of Medicine, Veterinary and Life 
      Sciences, New Lister Building, Glasgow Royal Infirmary, 10-16 Alexandra Parade, 
      Glasgow G31 2ER, UK.
FAU - Pitsiladis, Yannis P
AU  - Pitsiladis YP
AD  - FIMS Reference Collaborating Centre of Sports Medicine for Anti-Doping Research, 
      University of Brighton, Welkin House, 30 Carlisle Road, Eastbourne BN20 7SN, UK.
FAU - Celis-Morales, Carlos
AU  - Celis-Morales C
AD  - BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular & Medical 
      Sciences, University of Glasgow, Glasgow G12 8TA, UK.
FAU - Brown, Benjamin
AU  - Brown B
AD  - Human Nutrition, School of Medicine, College of Medicine, Veterinary and Life 
      Sciences, New Lister Building, Glasgow Royal Infirmary, 10-16 Alexandra Parade, 
      Glasgow G31 2ER, UK.
FAU - Speakman, John R
AU  - Speakman JR
AD  - Institute of Biological and Environmental Sciences, University of Aberdeen, 
      Zoology Building, Tillydrone Avenue, Aberdeen AB24 2TZ, UK.
FAU - Malkova, Dalia
AU  - Malkova D
AD  - Human Nutrition, School of Medicine, College of Medicine, Veterinary and Life 
      Sciences, New Lister Building, Glasgow Royal Infirmary, 10-16 Alexandra Parade, 
      Glasgow G31 2ER, UK.
LA  - eng
PT  - Journal Article
DEP - 20150617
PL  - Egypt
TA  - J Amino Acids
JT  - Journal of amino acids
JID - 101568074
PMC - PMC4488253
EDAT- 2015/07/15 06:00
MHDA- 2015/07/15 06:01
PMCR- 2015/06/17
CRDT- 2015/07/14 06:00
PHST- 2015/01/09 00:00 [received]
PHST- 2015/05/18 00:00 [revised]
PHST- 2015/05/19 00:00 [accepted]
PHST- 2015/07/14 06:00 [entrez]
PHST- 2015/07/15 06:00 [pubmed]
PHST- 2015/07/15 06:01 [medline]
PHST- 2015/06/17 00:00 [pmc-release]
AID - 10.1155/2015/352458 [doi]
PST - ppublish
SO  - J Amino Acids. 2015;2015:352458. doi: 10.1155/2015/352458. Epub 2015 Jun 17.