PMID- 26167495
OWN - NLM
STAT- MEDLINE
DCOM- 20160414
LR  - 20200306
IS  - 2314-6141 (Electronic)
IS  - 2314-6133 (Print)
VI  - 2015
DP  - 2015
TI  - Dendritic Cell-Based Immunotherapy Treatment for Glioblastoma Multiforme.
PG  - 717530
LID - 10.1155/2015/717530 [doi]
LID - 717530
AB  - Glioblastoma multiforme (GBM) is the most malignant glioma and patients diagnosed 
      with this disease had poor outcomes even treated with the combination of 
      conventional treatment (surgery, chemotherapy, and radiation). Dendritic cells 
      (DCs) are the most powerful antigen presenting cells and DC-based vaccination has 
      the potential to target and eliminate GBM cells and enhance the responses of 
      these cells to the existing therapies with minimal damage to the healthy tissues 
      around them. It can enhance recognition of GBM cells by the patients' immune 
      system and activate vast, potent, and long-lasting immune reactions to eliminate 
      them. Therefore, this therapy can prolong the survival of GBM patients and has 
      wide and bright future in the treatment of GBM. Also, the efficacy of this 
      therapy can be strengthened in several ways at some degree: the manipulation of 
      immune regulatory components or costimulatory molecules on DCs; the appropriate 
      choices of antigens for loading to enhance the effectiveness of the therapy; 
      regulation of positive regulators or negative regulators in GBM microenvironment.
FAU - Yang, Liu
AU  - Yang L
AD  - Department of Neurology, The First Hospital, Shanxi Medical University, No. 85 
      South Jie Fang Road, Taiyuan, Shanxi 030001, China.
FAU - Guo, Geng
AU  - Guo G
AD  - Department of Neurosurgery, The First Hospital, Shanxi Medical University, No. 85 
      South Jie Fang Road, Taiyuan, Shanxi 030001, China.
FAU - Niu, Xiao-yuan
AU  - Niu XY
AD  - Department of Neurology, The First Hospital, Shanxi Medical University, No. 85 
      South Jie Fang Road, Taiyuan, Shanxi 030001, China.
FAU - Liu, Jing
AU  - Liu J
AD  - Department of Neurosurgery, The First Hospital, Shanxi Medical University, No. 85 
      South Jie Fang Road, Taiyuan, Shanxi 030001, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20150617
PL  - United States
TA  - Biomed Res Int
JT  - BioMed research international
JID - 101600173
SB  - IM
MH  - Animals
MH  - *Brain Neoplasms/immunology/therapy
MH  - *Dendritic Cells/cytology/immunology/physiology
MH  - *Glioblastoma/immunology/therapy
MH  - Humans
MH  - *Immunotherapy
MH  - Mice
MH  - Models, Immunological
PMC - PMC4488155
EDAT- 2015/07/15 06:00
MHDA- 2016/04/15 06:00
PMCR- 2015/06/17
CRDT- 2015/07/14 06:00
PHST- 2014/09/25 00:00 [received]
PHST- 2015/01/08 00:00 [accepted]
PHST- 2015/07/14 06:00 [entrez]
PHST- 2015/07/15 06:00 [pubmed]
PHST- 2016/04/15 06:00 [medline]
PHST- 2015/06/17 00:00 [pmc-release]
AID - 10.1155/2015/717530 [doi]
PST - ppublish
SO  - Biomed Res Int. 2015;2015:717530. doi: 10.1155/2015/717530. Epub 2015 Jun 17.