PMID- 26169278
OWN - NLM
STAT- MEDLINE
DCOM- 20160218
LR  - 20181113
IS  - 1098-5522 (Electronic)
IS  - 0019-9567 (Print)
IS  - 0019-9567 (Linking)
VI  - 83
IP  - 10
DP  - 2015 Oct
TI  - Multifaceted Role of Heme during Severe Plasmodium falciparum Infections in 
      India.
PG  - 3793-9
LID - 10.1128/IAI.00531-15 [doi]
AB  - Several immunomodulatory factors are involved in malaria pathogenesis. Among 
      them, heme has been shown to play a role in the pathophysiology of severe malaria 
      in rodents, but its role in human severe malaria remains unclear. Circulating 
      levels of total heme and its main scavenger, hemopexin, along with 
      cytokine/chemokine levels and biological parameters, including hemoglobin and 
      creatinine levels, as well as transaminase activities, were measured in the 
      plasma of 237 Plasmodium falciparum-infected patients living in the state of 
      Odisha, India, where malaria is endemic. All patients were categorized into 
      well-defined groups of mild malaria, cerebral malaria (CM), or severe noncerebral 
      malaria, which included acute renal failure (ARF) and hepatopathy. Our results 
      show a significant increase in total plasma heme levels with malaria severity, 
      especially for CM and malarial ARF. Spearman rank correlation and canonical 
      correlation analyses have shown a correlation between total heme, hemopexin, 
      interleukin-10, tumor necrosis factor alpha, gamma interferon-induced protein 10 
      (IP-10), and monocyte chemotactic protein 1 (MCP-1) levels. In addition, 
      canonical correlations revealed that heme, along with IP-10, was associated with 
      the CM pathophysiology, whereas both IP-10 and MCP-1 together with heme 
      discriminated ARF. Altogether, our data indicate that heme, in association with 
      cytokines and chemokines, is involved in the pathophysiology of both CM and ARF 
      but through different mechanisms.
CI  - Copyright (c) 2015, American Society for Microbiology. All Rights Reserved.
FAU - Dalko, Esther
AU  - Dalko E
AD  - Centre for Infection and Immunity of Lille, INSERM U1019, CNRS UMR 8204, 
      Universite Lille Nord de France, Institut Pasteur de Lille, Lille, France.
FAU - Das, Bidyut
AU  - Das B
AD  - SCB Medical College, Cuttack, Odisha, India.
FAU - Herbert, Fabien
AU  - Herbert F
AD  - Centre for Infection and Immunity of Lille, INSERM U1019, CNRS UMR 8204, 
      Universite Lille Nord de France, Institut Pasteur de Lille, Lille, France.
FAU - Fesel, Constantin
AU  - Fesel C
AD  - Instituto Gulbenkian de Ciencia, Oeiras, Portugal.
FAU - Pathak, Sulabha
AU  - Pathak S
AD  - Department of Biological Sciences, Tata Institute of Fundamental Research, 
      Mumbai, India.
FAU - Tripathy, Rina
AU  - Tripathy R
AD  - SCB Medical College, Cuttack, Odisha, India.
FAU - Cazenave, Pierre-Andre
AU  - Cazenave PA
AD  - Centre for Infection and Immunity of Lille, INSERM U1019, CNRS UMR 8204, 
      Universite Lille Nord de France, Institut Pasteur de Lille, Lille, France 
      Immunologie-Immunopathologie-Immunotherapie, UPMC/CNRS UMR 7211, Paris, France.
FAU - Ravindran, Balachandran
AU  - Ravindran B
AD  - Institute of Life Sciences, Bhubaneswar, Odisha, India.
FAU - Sharma, Shobhona
AU  - Sharma S
AD  - Department of Biological Sciences, Tata Institute of Fundamental Research, 
      Mumbai, India.
FAU - Pied, Sylviane
AU  - Pied S
AUID- ORCID: 0000-0003-0642-1423
AD  - Centre for Infection and Immunity of Lille, INSERM U1019, CNRS UMR 8204, 
      Universite Lille Nord de France, Institut Pasteur de Lille, Lille, France 
      sylviane.pied@pasteur-lille.fr.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150713
PL  - United States
TA  - Infect Immun
JT  - Infection and immunity
JID - 0246127
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (IL10 protein, human)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 130068-27-8 (Interleukin-10)
RN  - 42VZT0U6YR (Heme)
RN  - 9013-71-2 (Hemopexin)
SB  - IM
MH  - Adult
MH  - Chemokine CCL2/blood
MH  - Disease Progression
MH  - Female
MH  - Heme/*metabolism
MH  - Hemopexin/metabolism
MH  - Humans
MH  - India
MH  - Interleukin-10/blood
MH  - Malaria, Falciparum/*blood/parasitology/pathology
MH  - Male
MH  - Middle Aged
MH  - Plasmodium falciparum/*physiology
MH  - Tumor Necrosis Factor-alpha/blood
MH  - Young Adult
PMC - PMC4567638
EDAT- 2015/07/15 06:00
MHDA- 2016/02/19 06:00
PMCR- 2016/04/01
CRDT- 2015/07/15 06:00
PHST- 2015/05/07 00:00 [received]
PHST- 2015/07/03 00:00 [accepted]
PHST- 2015/07/15 06:00 [entrez]
PHST- 2015/07/15 06:00 [pubmed]
PHST- 2016/02/19 06:00 [medline]
PHST- 2016/04/01 00:00 [pmc-release]
AID - IAI.00531-15 [pii]
AID - 00531-15 [pii]
AID - 10.1128/IAI.00531-15 [doi]
PST - ppublish
SO  - Infect Immun. 2015 Oct;83(10):3793-9. doi: 10.1128/IAI.00531-15. Epub 2015 Jul 
      13.