PMID- 26170010
OWN - NLM
STAT- MEDLINE
DCOM- 20151116
LR  - 20191210
IS  - 1532-8392 (Electronic)
IS  - 0046-8177 (Linking)
VI  - 46
IP  - 9
DP  - 2015 Sep
TI  - Gain of hTERC: a genetic marker of malignancy in oral potentially malignant 
      lesions.
PG  - 1275-81
LID - S0046-8177(15)00187-2 [pii]
LID - 10.1016/j.humpath.2015.05.013 [doi]
AB  - Oral squamous cell carcinoma (OSCC) is the most common oral cancer, and major 
      efforts is being made to identify molecular markers capable to differentiate oral 
      potentially malignant lesions (OPMLs) with indolent course from lesions with 
      aggressive behavior. We undertook a study to evaluate if gain of the human 
      telomerase RNA component (hTERC) gene in OPMLs could indicate lesions at high 
      risk of developing OSCC. The study was performed on 30 OPMLs with long-term 
      follow-up using a dual-color interphase fluorescence in situ hybridization (FISH) 
      for hTERC status. Progression to malignancy was observed in 9 of 10 cases 
      harboring hTERC gain and in 1 of 20 cases retaining a normal copy number of hTERC 
      (P < .0001). Combining morphological grading and FISH analysis, all the cases 
      with high-grade squamous intraepithelial lesion or carcinoma in situ harboring 
      hTERC amplification progressed to OSCC, whereas none of the low-grade squamous 
      intraepithelial lesions without hTERC gain progressed. Intermediate situations 
      occurred. The data suggest that precise morphological evaluation together with 
      FISH assessment for hTERC gain might pave the way to stratify OPMLs into 
      high-risk and low-risk categories and could be helpful in selecting the most 
      appropriate treatment.
CI  - Copyright (c) 2015 Elsevier Inc. All rights reserved.
FAU - Dorji, Tshering
AU  - Dorji T
AD  - Pathology and Laboratory Medicine Centro Diagnostico Italiano, Milan Italy 20147.
FAU - Monti, Valentina
AU  - Monti V
AD  - Section of Anatomic Pathology of the Department of Biomedical and Neuromotor 
      Sciences, of the University of Bologna, Bologna Italy.
FAU - Fellegara, Giovanni
AU  - Fellegara G
AD  - Pathology and Laboratory Medicine Centro Diagnostico Italiano, Milan Italy 20147.
FAU - Gabba, Silvia
AU  - Gabba S
AD  - Pathology and Laboratory Medicine Centro Diagnostico Italiano, Milan Italy 20147.
FAU - Grazioli, Vittorio
AU  - Grazioli V
AD  - Pathology and Laboratory Medicine Centro Diagnostico Italiano, Milan Italy 20147.
FAU - Repetti, Elena
AU  - Repetti E
AD  - Pathology and Laboratory Medicine Centro Diagnostico Italiano, Milan Italy 20147.
FAU - Marcialis, Chiara
AU  - Marcialis C
AD  - Pathology and Laboratory Medicine Centro Diagnostico Italiano, Milan Italy 20147.
FAU - Peluso, Sergio
AU  - Peluso S
AD  - Section of Anatomic Pathology of the Department of Biomedical and Neuromotor 
      Sciences, of the University of Bologna, Bologna Italy.
FAU - Di Ruzza, Davide
AU  - Di Ruzza D
AD  - Section of Anatomic Pathology of the Department of Biomedical and Neuromotor 
      Sciences, of the University of Bologna, Bologna Italy.
FAU - Neri, Fabrizio
AU  - Neri F
AD  - Opertative Unit of Maxillo-facial Surgery, Bellaria Hospital, Bologna, Italy.
FAU - Foschini, Maria P
AU  - Foschini MP
AD  - Section of Anatomic Pathology of the Department of Biomedical and Neuromotor 
      Sciences, of the University of Bologna, Bologna Italy. Electronic address: 
      mariapia.foschini@unibo.it.
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150530
PL  - United States
TA  - Hum Pathol
JT  - Human pathology
JID - 9421547
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (telomerase RNA)
RN  - 63231-63-0 (RNA)
RN  - EC 2.7.7.49 (Telomerase)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers, Tumor/*genetics
MH  - Carcinoma in Situ/enzymology/*genetics/mortality/pathology
MH  - Carcinoma, Squamous Cell/enzymology/*genetics/mortality/pathology
MH  - Disease Progression
MH  - Female
MH  - *Gene Amplification
MH  - Head and Neck Neoplasms/enzymology/*genetics/mortality/pathology
MH  - Humans
MH  - *In Situ Hybridization, Fluorescence
MH  - Kaplan-Meier Estimate
MH  - Male
MH  - Middle Aged
MH  - Mouth Neoplasms/enzymology/*genetics/mortality/pathology
MH  - Neoplasm Grading
MH  - Precancerous Conditions/enzymology/*genetics/mortality/pathology
MH  - Predictive Value of Tests
MH  - RNA/*genetics
MH  - Risk Assessment
MH  - Risk Factors
MH  - Squamous Cell Carcinoma of Head and Neck
MH  - Telomerase/*genetics
MH  - Time Factors
OTO - NOTNLM
OT  - 3q26
OT  - FISH
OT  - Genetic marker
OT  - Human telomerase RNA component (hTERC)
OT  - Oral potentially malignant lesions (OPMLs)
OT  - Oral squamous cell carcinoma (OSCC)
EDAT- 2015/07/15 06:00
MHDA- 2015/11/17 06:00
CRDT- 2015/07/15 06:00
PHST- 2015/02/06 00:00 [received]
PHST- 2015/05/06 00:00 [revised]
PHST- 2015/05/09 00:00 [accepted]
PHST- 2015/07/15 06:00 [entrez]
PHST- 2015/07/15 06:00 [pubmed]
PHST- 2015/11/17 06:00 [medline]
AID - S0046-8177(15)00187-2 [pii]
AID - 10.1016/j.humpath.2015.05.013 [doi]
PST - ppublish
SO  - Hum Pathol. 2015 Sep;46(9):1275-81. doi: 10.1016/j.humpath.2015.05.013. Epub 2015 
      May 30.