PMID- 26170534
OWN - NLM
STAT- MEDLINE
DCOM- 20160527
LR  - 20181113
IS  - 1466-1861 (Electronic)
IS  - 0962-9351 (Print)
IS  - 0962-9351 (Linking)
VI  - 2015
DP  - 2015
TI  - A Hyperlipidic Diet Combined with Short-Term Ovariectomy Increases Adiposity and 
      Hyperleptinemia and Decreases Cytokine Content in Mesenteric Adipose Tissue.
PG  - 923248
LID - 10.1155/2015/923248 [doi]
LID - 923248
AB  - Four-week-old female Wistar rats were divided into two groups and fed a control 
      diet (C) or a hyperlipidic diet (H) for 4 weeks. Rats from each group underwent 
      ovariectomy (OVX) or sham surgery (SHAM). They received C or H for the next four 
      weeks. The body weight gain (BW), food efficiency (FE), and carcass lipid content 
      were higher in the OVX H than in the SHAM H. The OVX H exhibited a higher serum 
      leptin level than other groups. IL-6, TNF-alpha, and IL-10 content of mesenteric 
      (MES) adipose tissue was lower in the OVX H than in the OVX C. IL-6, TNF-alpha, and 
      IL-10 content of retroperitoneal (RET) adipose tissue was lower in the SHAM H 
      than in the SHAM C. The SHAM H showed decreased TG relative to the SHAM C. 
      Similar results were obtained in relation to IL-6Ralpha, TNFR1, TLR-4, and MyD88 
      contents in the MES and RET white adipose tissue among the groups. A hyperlipidic 
      diet for 8 weeks combined with short-term ovariectomy decreases the cytokine 
      content of MES adipose tissues but increases BW, enhancing FE and elevating serum 
      leptin levels. These suggest that the absence of estrogens promotes metabolic 
      changes that may contribute to installation of a proinflammatory process induced 
      by a hyperlipidic diet.
FAU - Neto, Nelson Inacio Pinto
AU  - Neto NI
AD  - Departamento de Fisiologia, Disciplina de Fisiologia da Nutricao, Universidade 
      Federal de Sao Paulo, Rua Botucatu 862, 2nd floor, Edificio de Ciencias 
      Biomedicas, 04023060 Vila Clementino, SP, Brazil.
FAU - Rodrigues, Maria Elizabeth Sousa
AU  - Rodrigues ME
AD  - Departamento de Fisiologia, Disciplina de Fisiologia da Nutricao, Universidade 
      Federal de Sao Paulo, Rua Botucatu 862, 2nd floor, Edificio de Ciencias 
      Biomedicas, 04023060 Vila Clementino, SP, Brazil.
FAU - Hachul, Ana Claudia Losinskas
AU  - Hachul AC
AD  - Departamento de Fisiologia, Disciplina de Fisiologia da Nutricao, Universidade 
      Federal de Sao Paulo, Rua Botucatu 862, 2nd floor, Edificio de Ciencias 
      Biomedicas, 04023060 Vila Clementino, SP, Brazil.
FAU - Moreno, Mayara Franzoi
AU  - Moreno MF
AD  - Departamento de Fisiologia, Disciplina de Fisiologia da Nutricao, Universidade 
      Federal de Sao Paulo, Rua Botucatu 862, 2nd floor, Edificio de Ciencias 
      Biomedicas, 04023060 Vila Clementino, SP, Brazil.
FAU - Boldarine, Valter Tadeu
AU  - Boldarine VT
AD  - Departamento de Fisiologia, Disciplina de Fisiologia da Nutricao, Universidade 
      Federal de Sao Paulo, Rua Botucatu 862, 2nd floor, Edificio de Ciencias 
      Biomedicas, 04023060 Vila Clementino, SP, Brazil.
FAU - Ribeiro, Eliane Beraldi
AU  - Ribeiro EB
AD  - Departamento de Fisiologia, Disciplina de Fisiologia da Nutricao, Universidade 
      Federal de Sao Paulo, Rua Botucatu 862, 2nd floor, Edificio de Ciencias 
      Biomedicas, 04023060 Vila Clementino, SP, Brazil.
FAU - Oyama, Lila Missae
AU  - Oyama LM
AD  - Departamento de Fisiologia, Disciplina de Fisiologia da Nutricao, Universidade 
      Federal de Sao Paulo, Rua Botucatu 862, 2nd floor, Edificio de Ciencias 
      Biomedicas, 04023060 Vila Clementino, SP, Brazil.
FAU - Oller do Nascimento, Claudia Maria
AU  - Oller do Nascimento CM
AD  - Departamento de Fisiologia, Disciplina de Fisiologia da Nutricao, Universidade 
      Federal de Sao Paulo, Rua Botucatu 862, 2nd floor, Edificio de Ciencias 
      Biomedicas, 04023060 Vila Clementino, SP, Brazil.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150614
PL  - United States
TA  - Mediators Inflamm
JT  - Mediators of inflammation
JID - 9209001
RN  - 0 (Blood Glucose)
RN  - 0 (Cytokines)
RN  - 0 (Insulin)
RN  - 0 (Leptin)
SB  - IM
MH  - Adipose Tissue/*immunology
MH  - *Adiposity
MH  - Animals
MH  - Blood Glucose/analysis
MH  - Body Weight
MH  - Cytokines/*analysis
MH  - Diet
MH  - Female
MH  - Hyperlipidemias/*etiology
MH  - Insulin/blood
MH  - Leptin/blood
MH  - Mesentery/immunology
MH  - *Ovariectomy
MH  - Rats
MH  - Rats, Wistar
PMC - PMC4485502
EDAT- 2015/07/15 06:00
MHDA- 2016/05/28 06:00
PMCR- 2015/06/14
CRDT- 2015/07/15 06:00
PHST- 2014/11/25 00:00 [received]
PHST- 2015/04/10 00:00 [revised]
PHST- 2015/04/17 00:00 [accepted]
PHST- 2015/07/15 06:00 [entrez]
PHST- 2015/07/15 06:00 [pubmed]
PHST- 2016/05/28 06:00 [medline]
PHST- 2015/06/14 00:00 [pmc-release]
AID - 10.1155/2015/923248 [doi]
PST - ppublish
SO  - Mediators Inflamm. 2015;2015:923248. doi: 10.1155/2015/923248. Epub 2015 Jun 14.