PMID- 26170829
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150714
LR  - 20200930
IS  - 1673-5374 (Print)
IS  - 1876-7958 (Electronic)
IS  - 1673-5374 (Linking)
VI  - 10
IP  - 4
DP  - 2015 Apr
TI  - Human umbilical cord mesenchymal stem cells promote peripheral nerve repair via 
      paracrine mechanisms.
PG  - 651-8
LID - 10.4103/1673-5374.155442 [doi]
AB  - Human umbilical cord-derived mesenchymal stem cells (hUCMSCs) represent a 
      promising young-state stem cell source for cell-based therapy. hUCMSC 
      transplantation into the transected sciatic nerve promotes axonal regeneration 
      and functional recovery. To further clarify the paracrine effects of hUCMSCs on 
      nerve regeneration, we performed human cytokine antibody array analysis, which 
      revealed that hUCMSCs express 14 important neurotrophic factors. Enzyme-linked 
      immunosorbent assay and immunohistochemistry showed that brain-derived 
      neurotrophic factor, glial-derived neurotrophic factor, hepatocyte growth factor, 
      neurotrophin-3, basic fibroblast growth factor, type I collagen, fibronectin and 
      laminin were highly expressed. Treatment with hUCMSC-conditioned medium enhanced 
      Schwann cell viability and proliferation, increased nerve growth factor and 
      brain-derived neurotrophic factor expression in Schwann cells, and enhanced 
      neurite growth from dorsal root ganglion explants. These findings suggest that 
      paracrine action may be a key mechanism underlying the effects of hUCMSCs in 
      peripheral nerve repair.
FAU - Guo, Zhi-Yuan
AU  - Guo ZY
AD  - Institute of Orthopedics, Chinese PLA General Hospital, Beijing, China.
FAU - Sun, Xun
AU  - Sun X
AD  - Institute of Orthopedics, Chinese PLA General Hospital, Beijing, China.
FAU - Xu, Xiao-Long
AU  - Xu XL
AD  - Institute of Orthopedics, Chinese PLA General Hospital, Beijing, China.
FAU - Zhao, Qing
AU  - Zhao Q
AD  - Institute of Orthopedics, Chinese PLA General Hospital, Beijing, China.
FAU - Peng, Jiang
AU  - Peng J
AD  - Institute of Orthopedics, Chinese PLA General Hospital, Beijing, China ; The 
      Neural Regeneration Co-innovation Center of Jiangsu Province, Nantong, Jiangsu 
      Province, China.
FAU - Wang, Yu
AU  - Wang Y
AD  - Institute of Orthopedics, Chinese PLA General Hospital, Beijing, China ; The 
      Neural Regeneration Co-innovation Center of Jiangsu Province, Nantong, Jiangsu 
      Province, China.
LA  - eng
PT  - Journal Article
PL  - India
TA  - Neural Regen Res
JT  - Neural regeneration research
JID - 101316351
PMC - PMC4424761
OTO - NOTNLM
OT  - Schwann cells
OT  - axons
OT  - conditioned medium
OT  - dorsal root ganglion
OT  - human umbilical cord-derived mesenchymal stem cells
OT  - nerve regeneration
OT  - neural regeneration
OT  - neurotrophic factors
OT  - peripheral nerve regeneration
COIS- Conflicts of interest: None declared.
EDAT- 2015/07/15 06:00
MHDA- 2015/07/15 06:01
PMCR- 2015/04/01
CRDT- 2015/07/15 06:00
PHST- 2015/02/10 00:00 [accepted]
PHST- 2015/07/15 06:00 [entrez]
PHST- 2015/07/15 06:00 [pubmed]
PHST- 2015/07/15 06:01 [medline]
PHST- 2015/04/01 00:00 [pmc-release]
AID - NRR-10-651 [pii]
AID - 10.4103/1673-5374.155442 [doi]
PST - ppublish
SO  - Neural Regen Res. 2015 Apr;10(4):651-8. doi: 10.4103/1673-5374.155442.