PMID- 26171014
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1792-1074 (Print)
IS  - 1792-1082 (Electronic)
IS  - 1792-1074 (Linking)
VI  - 10
IP  - 1
DP  - 2015 Jul
TI  - Expression and clinical significance of mammalian target of rapamycin/P70 
      ribosomal protein S6 kinase signaling pathway in human colorectal carcinoma 
      tissue.
PG  - 277-282
AB  - The activation of mammalian target of rapamycin (mTOR) has been reported in tumor 
      development, but the role of mTOR in colorectal carcinomas remains unclear. The 
      aim of the present study was to investigate the significance of mTOR and its 
      downstream effector 70 kDa ribosomal protein S6 kinase (P70S6K) in human 
      colorectal carcinomas. The phosphorylated (p-)mTOR and p-P70S6K proteins were 
      examined by immunohistochemistry performed on tissue microarray containing tissue 
      samples obtained from colorectal carcinoma (n=111), adenomatous polyps (n=40) and 
      normal colonic mucosa (n=40), with a comparison between the expression of these 
      proteins and the clinicopathological parameters of patients with carcinomas. The 
      positive expression rates of p-mTOR and p-P70S6k were 60.4 and 65.8%, 
      respectively, in colorectal carcinoma tissue, which was significantly increased 
      compared with the tissue from adenomatous polyps (27.5 and 20%, respectively) and 
      normal colonic mucosa (10.0 and 5.0%, respectively) (P<0.05). Overexpression of 
      the p-mTOR and p-P70S6K proteins was significantly associated with the 
      tumor-node-metastasis stage, the occurrence of distal and lymph node metastasis 
      and the degree of differentiation. Aberrant expression of p-mTOR and p-P70S6K may 
      contribute to the pathogenesis, growth, invasion and metastasis of colorectal 
      carcinoma. The phosphorylation of these proteins was considered to be a promising 
      marker to indicate the aggressive behaviors and prognosis of colorectal 
      carcinomas. The overexpression of the mTOR/P70S6K signaling pathway may play an 
      important role in colorectal carcinoma carcinogenesis. The expression of p-mTOR 
      and p-P70S6K was considered as a promising marker to indicate the aggressive 
      behaviors and prognosis of human colorectal carcinomas.
FAU - Lu, Qingjun
AU  - Lu Q
AD  - Department of General Surgery, Binzhou Central Hospital, Binzhou Medical College, 
      Binzhou, Shandong, P.R. China.
FAU - Wang, Jieshu
AU  - Wang J
AD  - Department of General Surgery, Binzhou Central Hospital, Binzhou Medical College, 
      Binzhou, Shandong, P.R. China.
FAU - Yu, Gang
AU  - Yu G
AD  - Department of General Surgery, Binzhou Central Hospital, Binzhou Medical College, 
      Binzhou, Shandong, P.R. China.
FAU - Guo, Tianhua
AU  - Guo T
AD  - Department of General Surgery, Binzhou Central Hospital, Binzhou Medical College, 
      Binzhou, Shandong, P.R. China.
FAU - Hu, Chun
AU  - Hu C
AD  - Department of Oncology, Ruijin Hospital, Shanghai Jiaotong University, Shanghai, 
      P.R. China.
FAU - Ren, Peng
AU  - Ren P
AD  - Department of General Surgery, Binzhou Central Hospital, Binzhou Medical College, 
      Binzhou, Shandong, P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20150519
PL  - Greece
TA  - Oncol Lett
JT  - Oncology letters
JID - 101531236
PMC - PMC4487095
OTO - NOTNLM
OT  - colorectal cancer
OT  - immunohistochemistry
OT  - mammalian target of rapamycin/70 kDa ribosomal protein S6 kinase
OT  - reverse transcription-polymerase chain reaction
EDAT- 2015/07/15 06:00
MHDA- 2015/07/15 06:01
PMCR- 2015/05/19
CRDT- 2015/07/15 06:00
PHST- 2014/05/17 00:00 [received]
PHST- 2015/02/11 00:00 [accepted]
PHST- 2015/07/15 06:00 [entrez]
PHST- 2015/07/15 06:00 [pubmed]
PHST- 2015/07/15 06:01 [medline]
PHST- 2015/05/19 00:00 [pmc-release]
AID - OL-0-0-3228 [pii]
AID - 10.3892/ol.2015.3228 [doi]
PST - ppublish
SO  - Oncol Lett. 2015 Jul;10(1):277-282. doi: 10.3892/ol.2015.3228. Epub 2015 May 19.