PMID- 26171168
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220330
IS  - 2049-9434 (Print)
IS  - 2049-9442 (Electronic)
IS  - 2049-9434 (Linking)
VI  - 3
IP  - 4
DP  - 2015 Jul
TI  - Analysis of total immunoglobulin E and specific immunoglobulin E of 3,721 
      patients with allergic disease.
PG  - 573-577
AB  - Due to the increase in the prevalence and incidence of allergic diseases, 
      improving the sensitivity and specificity of screening indexes is critical. Total 
      immunoglobulin E (IgE) is a traditional index for judging allergic diseases, 
      while its specificity is relatively poor. Serum-specific IgE (sIgE) is an 
      objective index with high specificity in the diagnosis of allergic diseases. In 
      the present research, the total IgE and sIgE of 3,721 patients with allergic 
      diseases were analyzed to further illuminate the association between them. The 
      data were derived from 3,721 patients. The serum-sIgE to 14 types of common 
      allergens and total IgE were detected. A total of 2,419 cases (65.0%) of 3,721 
      patients exhibited increasing total IgE and 1,215 patients (32.7%) exhibited 
      positive sIgE. The consistency rate of the two indexes was 60.4%, and the kappa-value 
      was 0.28. In 135 patients with normal total IgE, 82.2% exhibited one sIgE 
      positive and 17.8% exhibited two or more sIgE positive. While the number of 
      positive sIgE increased and the detecting level enhanced, the number of positive 
      total IgE markedly increased. Patients (84.1%) with increasing total IgE were 
      associated with positive sIgE, but the increase of total IgE could not be 
      completely explained by the total accumulation of sIgE. Total IgE may play an 
      important role on screening allergic disease while sIgE could be used as crucial 
      evidence for allergy diagnosis. Although the consistency of the two methods was 
      poor, neither total IgE nor sIgE could replace each other. Combining the two 
      indexes with clinical manifestations together will improve the method.
FAU - Chang, Man-Li
AU  - Chang ML
AD  - Department of Laboratory Medicine, The Second Affiliated Hospital of Harbin 
      Medical University, Harbin, Heilongjiang 150086, P.R. China.
FAU - Cui, Can
AU  - Cui C
AD  - Department of Endocrinology and Metabolism, The Second Affiliated Hospital of 
      Harbin Medical University, Harbin, Heilongjiang 150086, P.R. China.
FAU - Liu, Yan-Hong
AU  - Liu YH
AD  - Department of Laboratory Medicine, The Second Affiliated Hospital of Harbin 
      Medical University, Harbin, Heilongjiang 150086, P.R. China.
FAU - Pei, Li-Chun
AU  - Pei LC
AD  - Department of Geriatrics, The Second Affiliated Hospital of Harbin Medical 
      University, Harbin, Heilongjiang 150086, P.R. China.
FAU - Shao, Bing
AU  - Shao B
AD  - Department of Molecular Epidemiology, Harbin Medical University, Harbin, 
      Heilongjiang 150086, P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20150429
PL  - England
TA  - Biomed Rep
JT  - Biomedical reports
JID - 101613227
PMC - PMC4486958
OTO - NOTNLM
OT  - Harbin
OT  - allergen
OT  - consistency rate
OT  - specific immunoglobulin E
OT  - total immunoglobulin E
EDAT- 2015/07/15 06:00
MHDA- 2015/07/15 06:01
PMCR- 2015/04/29
CRDT- 2015/07/15 06:00
PHST- 2015/02/13 00:00 [received]
PHST- 2015/03/31 00:00 [accepted]
PHST- 2015/07/15 06:00 [entrez]
PHST- 2015/07/15 06:00 [pubmed]
PHST- 2015/07/15 06:01 [medline]
PHST- 2015/04/29 00:00 [pmc-release]
AID - BR-0-0-455 [pii]
AID - 10.3892/br.2015.455 [doi]
PST - ppublish
SO  - Biomed Rep. 2015 Jul;3(4):573-577. doi: 10.3892/br.2015.455. Epub 2015 Apr 29.