PMID- 26173184
OWN - NLM
STAT- MEDLINE
DCOM- 20160119
LR  - 20220408
IS  - 1527-3350 (Electronic)
IS  - 0270-9139 (Linking)
VI  - 62
IP  - 4
DP  - 2015 Oct
TI  - Kupffer cell-monocyte communication is essential for initiating murine liver 
      progenitor cell-mediated liver regeneration.
PG  - 1272-84
LID - 10.1002/hep.27977 [doi]
AB  - Liver progenitor cells (LPCs) are necessary for repair in chronic liver disease 
      because the remaining hepatocytes cannot replicate. However, LPC numbers also 
      correlate with disease severity and hepatocellular carcinoma risk. Thus, the 
      progenitor cell response in diseased liver may be regulated to optimize liver 
      regeneration and minimize the likelihood of tumorigenesis. How this is achieved 
      is currently unknown. Human and mouse diseased liver contain two subpopulations 
      of macrophages with different ontogenetic origins: prenatal yolk sac-derived 
      Kupffer cells and peripheral blood monocyte-derived macrophages. We examined the 
      individual role(s) of Kupffer cells and monocyte-derived macrophages in the 
      induction of LPC proliferation using clodronate liposome deletion of Kupffer 
      cells and adoptive transfer of monocytes, respectively, in the choline-deficient, 
      ethionine-supplemented diet model of liver injury and regeneration. Clodronate 
      liposome treatment reduced initial liver monocyte numbers together with the 
      induction of injury and LPC proliferation. Adoptive transfer of monocytes 
      increased the induction of liver injury, LPC proliferation, and tumor necrosis 
      factor-alpha production. CONCLUSION: Kupffer cells control the initial accumulation 
      of monocyte-derived macrophages. These infiltrating monocytes are in turn 
      responsible for the induction of liver injury, the increase in tumor necrosis 
      factor-alpha, and the subsequent proliferation of LPCs.
CI  - (c) 2015 by the American Association for the Study of Liver Diseases.
FAU - Elsegood, Caryn L
AU  - Elsegood CL
AD  - School of Chemistry and Biochemistry, The University of Western Australia, 
      Crawley, Western Australia, Australia.
AD  - School of Biomedical Sciences, CHIRI Biosciences Research Precinct, Curtin 
      University, Bentley, Western Australia, Australia.
FAU - Chan, Chun Wei
AU  - Chan CW
AD  - School of Medicine and Pharmacology, The University of Western Australia, 
      Fremantle, Western Australia, Australia.
AD  - School of Biological Sciences and Biotechnology, Murdoch University, Murdoch, 
      Western Australia, Australia.
FAU - Degli-Esposti, Mariapia A
AU  - Degli-Esposti MA
AD  - Immunology and Virology Program, Centre for Ophthalmology and Visual Science, The 
      University of Western Australia, Nedlands, Western Australia, Australia.
AD  - Centre for Experimental Immunology, Lions Eye Institute, Nedlands, Western 
      Australia, Australia.
FAU - Wikstrom, Matthew E
AU  - Wikstrom ME
AD  - Immunology and Virology Program, Centre for Ophthalmology and Visual Science, The 
      University of Western Australia, Nedlands, Western Australia, Australia.
AD  - Centre for Experimental Immunology, Lions Eye Institute, Nedlands, Western 
      Australia, Australia.
FAU - Domenichini, Alice
AU  - Domenichini A
AD  - School of Biomedical Sciences, CHIRI Biosciences Research Precinct, Curtin 
      University, Bentley, Western Australia, Australia.
FAU - Lazarus, Kyren
AU  - Lazarus K
AD  - School of Biomedical Sciences, CHIRI Biosciences Research Precinct, Curtin 
      University, Bentley, Western Australia, Australia.
AD  - Harry Perkins Institute of Medical Research, QEII Medical Centre, Nedlands and 
      Centre for Medical Research, The University of Western Australia, Crawley, 
      Western Australia, Australia.
FAU - van Rooijen, Nico
AU  - van Rooijen N
AD  - Department of Molecular Cell Biology, VU Medical Center, Amsterdam, The 
      Netherlands.
FAU - Ganss, Ruth
AU  - Ganss R
AD  - Harry Perkins Institute of Medical Research, QEII Medical Centre, Nedlands and 
      Centre for Medical Research, The University of Western Australia, Crawley, 
      Western Australia, Australia.
FAU - Olynyk, John K
AU  - Olynyk JK
AD  - School of Biomedical Sciences, CHIRI Biosciences Research Precinct, Curtin 
      University, Bentley, Western Australia, Australia.
AD  - Department of Gastroenterology and Hepatology, Fiona Stanley and Fremantle 
      Hospitals, South Metropolitan Health Service, Western Australia, Australia.
AD  - Institute for Immunology and Infectious Diseases, Murdoch University, Murdoch, 
      Western Australia, Australia.
FAU - Yeoh, George C T
AU  - Yeoh GC
AD  - School of Chemistry and Biochemistry, The University of Western Australia, 
      Crawley, Western Australia, Australia.
AD  - Harry Perkins Institute of Medical Research, QEII Medical Centre, Nedlands and 
      Centre for Medical Research, The University of Western Australia, Crawley, 
      Western Australia, Australia.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150731
PL  - United States
TA  - Hepatology
JT  - Hepatology (Baltimore, Md.)
JID - 8302946
SB  - IM
MH  - Animals
MH  - Cell Communication/*physiology
MH  - Kupffer Cells/*physiology
MH  - Liver/*cytology
MH  - Liver Regeneration/*physiology
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Monocytes/*physiology
MH  - Stem Cells/*physiology
EDAT- 2015/07/15 06:00
MHDA- 2016/01/20 06:00
CRDT- 2015/07/15 06:00
PHST- 2014/12/22 00:00 [received]
PHST- 2015/06/10 00:00 [revised]
PHST- 2015/07/04 00:00 [accepted]
PHST- 2015/07/15 06:00 [entrez]
PHST- 2015/07/15 06:00 [pubmed]
PHST- 2016/01/20 06:00 [medline]
AID - 10.1002/hep.27977 [doi]
PST - ppublish
SO  - Hepatology. 2015 Oct;62(4):1272-84. doi: 10.1002/hep.27977. Epub 2015 Jul 31.