PMID- 26174457
OWN - NLM
STAT- MEDLINE
DCOM- 20160414
LR  - 20150716
IS  - 1735-8604 (Electronic)
IS  - 1735-8582 (Linking)
VI  - 9
IP  - 4
DP  - 2015 Jul
TI  - T helper 1 and T helper 2 cytokines in atopic children with steroid-sensitive 
      nephrotic syndrome.
PG  - 298-305
AB  - INTRODUCTION: A higher incidence of allergic disorders has been documented in 
      children with steroid-sensitive nephrotic syndrome (SSNS); however, the role of 
      cytokines associated with T helper 1 and T helper 2 cells is not fully 
      elucidated. This study aimed to evaluate the role of T helper 1 and T helper 2 
      cytokines in both remission and activity phases among atopic versus nonatopic 
      children with SSNS. MATERIALS AND METHODS: Fifty-two children with SSNS (21 with 
      atopic disorders and 31 nonatopics) and 60 healthy children were enrolled in the 
      study. The healthy controls were comparable with the patients in terms of age and 
      sex distribution. Serum levels of immunoglobulin E (IgE), interleukin (IL)-2, 
      tumor necrosis factor (TNF)-alpha, IL-4, and IL-13 were measured in activity and 
      remission phases of the disease and in controls. RESULTS: Serum levels of IgE, 
      TNF-alpha, IL-4, and IL-13 were significantly increased in the children with SSNS 
      during the active compared to remission phase and the controls. T helper 2 
      markers (IgE, IL-4, and IL-13) were also higher in the atopic patients with SSNS 
      than those without atopy. No significant difference was observed in IL-2 levels 
      between the SSNS children in activity and remission phases and the controls, or 
      between atopic and nonatopic children with SSNS in activity and remission phases. 
      CONCLUSIONS: Our findings suggested that type 2 immune response prevailed during 
      the active stage in children with SSNS, atopic or not, with persistent elevation 
      of IgE during remission. T helper 2 imbalance was markedly exaggerated in atopic 
      children.
FAU - Youssef, Doaa Mohammed
AU  - Youssef DM
AD  - Department of pediatric nephrology, Zagazig University, Zagazig, Egypt. 
      dody5176@yahoo.com.
FAU - Elbehidy, Rabab Mohammed
AU  - Elbehidy RM
FAU - El-Shal, Amal Saeed
AU  - El-Shal AS
FAU - Sherief, Laila Metwaly
AU  - Sherief LM
LA  - eng
PT  - Journal Article
PL  - Iran
TA  - Iran J Kidney Dis
JT  - Iranian journal of kidney diseases
JID - 101316967
RN  - 0 (Cytokines)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - VB0R961HZT (Prednisone)
SB  - IM
MH  - Case-Control Studies
MH  - Child
MH  - Child, Preschool
MH  - Cytokines/*blood
MH  - Female
MH  - Humans
MH  - Hypersensitivity/*blood
MH  - Immunoglobulin E/*blood
MH  - Male
MH  - Nephrotic Syndrome/*blood/drug therapy
MH  - Prednisone/*therapeutic use
MH  - T-Lymphocytes, Helper-Inducer/*immunology
EDAT- 2015/07/16 06:00
MHDA- 2016/04/15 06:00
CRDT- 2015/07/16 06:00
PHST- 2014/11/12 00:00 [received]
PHST- 2015/02/26 00:00 [accepted]
PHST- 2015/02/17 00:00 [revised]
PHST- 2015/07/16 06:00 [entrez]
PHST- 2015/07/16 06:00 [pubmed]
PHST- 2016/04/15 06:00 [medline]
AID - 1989/787 [pii]
PST - ppublish
SO  - Iran J Kidney Dis. 2015 Jul;9(4):298-305.