PMID- 26175754
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150716
LR  - 20200930
IS  - 1664-8021 (Print)
IS  - 1664-8021 (Electronic)
IS  - 1664-8021 (Linking)
VI  - 6
DP  - 2015
TI  - DNA methylation and single nucleotide variants in the brain-derived neurotrophic 
      factor (BDNF) and oxytocin receptor (OXTR) genes are associated with 
      anxiety/depression in older women.
PG  - 230
LID - 10.3389/fgene.2015.00230 [doi]
LID - 230
AB  - BACKGROUND: Environmental effects and personal experiences could be expressed in 
      individuals through epigenetic non-structural changes such as DNA methylation. 
      This methylation could up- regulate or down-regulate corresponding gene 
      expressions and modify related phenotypes. DNA methylation increases with aging 
      and could be related to the late expression of some forms of mental disease. The 
      objective of this study was to evaluate the association between anxiety disorders 
      and/or depression in older women and DNA methylation for four genes related to 
      anxiety or depression. METHODS: Women aged 65 and older with (n = 19) or without 
      (n = 24) anxiety disorders and/or major depressive episode (DSM-IV), were 
      recruited. DNA methylation and single nucleotide variant (SNV) were evaluated 
      from saliva, respectively by pyrosequencing and by PCR, for the following genes: 
      brain-derived neurotrophic factor (BDNF; rs6265), oxytocin receptor (OXTR; 
      rs53576), serotonin transporter (SLC6A4; rs25531), and apolipoprotein E (APOE; 
      rs429358 and rs7412). RESULTS: A greater BDNF DNA methylation was observed in 
      subjects with anxiety/depression compared to control group subjects (Mean: 2.92 
      SD +/- 0.74 vs. 2.34 +/- 0.42; p= 0.0026). This difference was more pronounced in 
      subjects carrying the BDNF rs6265 CT genotype (2.99 +/- 0.41 vs. 2.27 +/- 0.26; p= 
      0.0006) than those carrying the CC genotype (p= 0.0332); no subjects with the TT 
      genotype were observed. For OXTR, a greater DNA methylation was observed in 
      subjects with anxiety/depression, but only for those carrying the AA genotype of 
      the OXTR rs53576 SNV, more particularly at one out of the seven CpGs studied 
      (7.01 +/- 0.94 vs. 4.44 +/- 1.11; p= 0.0063). No significant differences were 
      observed for APOE and SLC6A4. CONCLUSION: These results suggest that DNA 
      methylation in interaction with SNV variations in BDNF and OXTR, are associated 
      with the occurrence of anxiety/depression in older women.
FAU - Chagnon, Yvon C
AU  - Chagnon YC
AD  - Department of Psychiatry and Neurosciences, Laval University, Quebec City QC, 
      Canada ; Research Center: Institut Universitaire en Sante Mentale de Quebec, 
      Quebec City QC, Canada.
FAU - Potvin, Olivier
AU  - Potvin O
AD  - Research Center: Institut Universitaire en Sante Mentale de Quebec, Quebec City 
      QC, Canada.
FAU - Hudon, Carol
AU  - Hudon C
AD  - Research Center: Institut Universitaire en Sante Mentale de Quebec, Quebec City 
      QC, Canada ; School of Psychology, Laval University, Quebec City QC, Canada.
FAU - Preville, Michel
AU  - Preville M
AD  - Department of Sciences de la Sante Communautaire, Sherbrooke University, 
      Sherbrooke QC, Canada.
LA  - eng
PT  - Journal Article
DEP - 20150630
PL  - Switzerland
TA  - Front Genet
JT  - Frontiers in genetics
JID - 101560621
PMC - PMC4485183
OTO - NOTNLM
OT  - BDNF Val66Met
OT  - OXTR
OT  - aging
OT  - anxiety
OT  - methylation
OT  - snps
EDAT- 2015/07/16 06:00
MHDA- 2015/07/16 06:01
PMCR- 2015/06/30
CRDT- 2015/07/16 06:00
PHST- 2015/01/21 00:00 [received]
PHST- 2015/06/15 00:00 [accepted]
PHST- 2015/07/16 06:00 [entrez]
PHST- 2015/07/16 06:00 [pubmed]
PHST- 2015/07/16 06:01 [medline]
PHST- 2015/06/30 00:00 [pmc-release]
AID - 10.3389/fgene.2015.00230 [doi]
PST - epublish
SO  - Front Genet. 2015 Jun 30;6:230. doi: 10.3389/fgene.2015.00230. eCollection 2015.