PMID- 26175937
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150715
LR  - 20200930
IS  - 2156-6976 (Print)
IS  - 2156-6976 (Electronic)
IS  - 2156-6976 (Linking)
VI  - 5
IP  - 5
DP  - 2015
TI  - Snail interacts with Id2 in the regulation of TNF-alpha-induced cancer cell invasion 
      and migration in OSCC.
PG  - 1680-91
AB  - The inflammatory tumor microenvironment has been identified to play a pivotal 
      role in tumor development and metastasis. Tumor necrosis factor-alpha (TNF-alpha) is one 
      of the key cytokines that regulate the inflammatory processes in tumor promotion. 
      In the current study, we treated three oral squamous cell carcinoma (OSCC) cell 
      lines with TNF-alpha to study its role in inflammation-induced tumor progression. 
      Here we show that TNF-alpha induces stabilization of the transcriptional repressor 
      Snail and activates NF-kappaB pathway in the three OSCC cell lines. These activities 
      resulted in the increased motility and invasiveness of three OSCC cell lines. In 
      addition, upon dealing with TNF-alpha for the indicated time, three OSCC cell lines 
      underwent epithelial-to-mesenchymal transition (EMT), in which they presented a 
      fibroblast-like phenotype and had a decreased expression of epithelial marker 
      (E-cadherin) and an increased expression of mesenchymal marker (vimentin). We 
      further demonstrated that TNF-alpha can up-regulate the expression of Id2 while 
      inducing an EMT in oral cancer cells. Finally, we showed that Id2 interacted with 
      Snail which may constrain Snail-dependent suppression of E-cadherin. In 
      conclusion, our study indicates that TNF-alpha induces Snail stabilization is 
      dependent on the activation of NF-kappaB pathway and results in increasing cell 
      invasion and migration in OSCC cells. Id2 may contribute to regulate the function 
      of Snail during TNF-alpha-mediated EMT in OSCC. These findings have significant 
      implications for inflammation-induced tumor promotion in OSCC.
FAU - Zhou, Jing-Ping
AU  - Zhou JP
AD  - Department of Oral Medicine, School of Stomatology, Wannan Medical College Wuhu, 
      People's Republic of China.
FAU - Gao, Zhen-Lin
AU  - Gao ZL
AD  - Department of Oncology IV, First Hospital of Shijiazhuang Shijiazhuang, People's 
      Republic of China.
FAU - Zhou, Mei-Ling
AU  - Zhou ML
AD  - Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University Nanjing, 
      People's Republic of China ; Department of Basic Science of Stomatology, 
      Affiliated Hospital of Stomatology, Nanjing Medical University Nanjing, People's 
      Republic of China.
FAU - He, Meng-Ying
AU  - He MY
AD  - Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University Nanjing, 
      People's Republic of China ; Department of Basic Science of Stomatology, 
      Affiliated Hospital of Stomatology, Nanjing Medical University Nanjing, People's 
      Republic of China.
FAU - Xu, Xiao-Hui
AU  - Xu XH
AD  - Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University Nanjing, 
      People's Republic of China ; Department of The First Outpatient, Affiliated 
      Hospital of Stomatology, Nanjing Medical University Nanjing, People's Republic of 
      China.
FAU - Tao, De-Tao
AU  - Tao DT
AD  - Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital of 
      Wannan Medical College Wuhu, People's Republic of China.
FAU - Yang, Cong-Chong
AU  - Yang CC
AD  - Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University Nanjing, 
      People's Republic of China ; Department of Basic Science of Stomatology, 
      Affiliated Hospital of Stomatology, Nanjing Medical University Nanjing, People's 
      Republic of China.
FAU - Liu, Lai-Kui
AU  - Liu LK
AD  - Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University Nanjing, 
      People's Republic of China ; Department of Basic Science of Stomatology, 
      Affiliated Hospital of Stomatology, Nanjing Medical University Nanjing, People's 
      Republic of China.
LA  - eng
PT  - Journal Article
DEP - 20150415
PL  - United States
TA  - Am J Cancer Res
JT  - American journal of cancer research
JID - 101549944
PMC - PMC4497435
OTO - NOTNLM
OT  - Epithelial-to-mesenchymal transition
OT  - Id2
OT  - Snail
OT  - oral squamous cell carcinoma
OT  - tumor necrosis factor-alpha
EDAT- 2015/07/16 06:00
MHDA- 2015/07/16 06:01
PMCR- 2015/04/15
CRDT- 2015/07/16 06:00
PHST- 2015/02/04 00:00 [received]
PHST- 2015/04/10 00:00 [accepted]
PHST- 2015/07/16 06:00 [entrez]
PHST- 2015/07/16 06:00 [pubmed]
PHST- 2015/07/16 06:01 [medline]
PHST- 2015/04/15 00:00 [pmc-release]
PST - epublish
SO  - Am J Cancer Res. 2015 Apr 15;5(5):1680-91. eCollection 2015.