PMID- 26176090
OWN - NLM
STAT- MEDLINE
DCOM- 20150812
LR  - 20150715
IS  - 0172-6390 (Print)
IS  - 0172-6390 (Linking)
VI  - 61
IP  - 131
DP  - 2014 May
TI  - Promotive Effects of Dcr3 Gene on the Occurrence and Progression of Gastric 
      Cancer and its Mechanism.
PG  - 880-4
AB  - BACKGROUND/AIMS: To observe the effects of DcR3 gene on the occurrence and 
      progression of gastric cancer and explore its mechanism. METHODOLOGY: DcR3 mRNA 
      expressions in both gastric normal tissue and gastric cancer tissue were detected 
      with RT-PCR. Apoptosis index (AI) was determined with terminal deoxynucleotidyl 
      transferase-mediated dUTP nick end labeling (TUNEL). RESULTS: Positive rate of 
      DcR3 mRNA expression was significantly higher in gastric cancer tissue than in 
      gastric normal tissue (P < 0.01). The level of DcR3 mRNA expression was related 
      to differentiation, lymphatic metastasis and TNM staging (P < 0.05). The level of 
      DcR3 mRNA expression was inversely correlated with AI (P < 0.01). CONCLUSION: 
      DcR3 plays an important role in the occurrence and progression of gastric cancer 
      possibly through inhibiting gastric cancer cell apoptosis.
FAU - Zheng, Xue-Feng
AU  - Zheng XF
FAU - Miao, Lan-Ying
AU  - Miao LY
FAU - Li, Shu
AU  - Li S
FAU - Wang, Yu-Bin
AU  - Wang YB
LA  - eng
PT  - Journal Article
PL  - Greece
TA  - Hepatogastroenterology
JT  - Hepato-gastroenterology
JID - 8007849
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, Tumor Necrosis Factor, Member 6b)
RN  - 0 (TNFRSF6B protein, human)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Apoptosis
MH  - Case-Control Studies
MH  - Cell Differentiation
MH  - Disease Progression
MH  - Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - Lymphatic Metastasis
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - RNA, Messenger/analysis
MH  - Receptors, Tumor Necrosis Factor, Member 6b/*genetics
MH  - Stomach Neoplasms/*genetics/pathology
EDAT- 2014/05/01 00:00
MHDA- 2015/08/13 06:00
CRDT- 2015/07/16 06:00
PHST- 2015/07/16 06:00 [entrez]
PHST- 2014/05/01 00:00 [pubmed]
PHST- 2015/08/13 06:00 [medline]
PST - ppublish
SO  - Hepatogastroenterology. 2014 May;61(131):880-4.