PMID- 26176300
OWN - NLM
STAT- MEDLINE
DCOM- 20171023
LR  - 20171023
IS  - 1756-185X (Electronic)
IS  - 1756-1841 (Linking)
VI  - 19
IP  - 12
DP  - 2016 Dec
TI  - A retrospective study on 158 Thai patients with juvenile idiopathic arthritis 
      followed in a single center over a 15-year period.
PG  - 1342-1350
LID - 10.1111/1756-185X.12637 [doi]
AB  - AIM: To determine the outcomes of juvenile idiopathic arthritis (JIA) in Thai 
      children. METHODS: A retrospective cohort study. All JIA patients in a 
      rheumatology clinic, Ramathibodi Hospital, between July 1997 and December 2012 
      were enrolled. The patient data were reviewed from medical records. At the most 
      recent follow-up visit, patient outcomes were assessed in three aspects: disease 
      status, functional outcomes and structural damage. RESULTS: Of 168 patients, 158 
      (94.0%) were assessed in disease status and functional outcomes, with 114 
      patients (67.9%) assessed in three aspects over 4 years of disease. The most 
      common JIA category was systemic JIA (SJIA) (33.8%), followed by 
      enthesitis-related arthritis (ERA) (24.8%), oligoarthritis (18.5%), rheumatoid 
      factor (RF)-negative polyarthritis (15.3%), RF-positive polyarthritis (7.6%) and 
      one undifferentiated arthritis. SJIA had the highest remission rate due to early 
      diagnosis and prompt treatment compared to other categories, whereas RF-positive 
      polyarthritis carried the worst prognosis in three aspects, followed by ERA. 
      Moreover, ERA patients had the highest failure rate in conventional therapy, half 
      of whom had combined treatment with biologic agents and presence of human 
      leukocyte antigen (HLA)-B27 was a predictor for biologic treatment in ERA 
      patients. In addition, disease duration > 2 years or failure of conventional 
      therapy was a predictor of structural bone damage. CONCLUSIONS: SJIA had the 
      highest remission rate, whereas RF-positive polyarthritis had the worst outcome 
      in three aspects. Prolonged disease duration or failure of conventional therapy 
      was a predictor of structural bone damage, while HLA-B27 was a predictor for 
      biologic treatment in ERA patients.
CI  - (c) 2015 Asia Pacific League of Associations for Rheumatology and Wiley Publishing 
      Asia Pty Ltd.
FAU - Vilaiyuk, Soamarat
AU  - Vilaiyuk S
AD  - Division of Allergy, Immunology, and Rheumatology, Department of Pediatrics, 
      Mahidol University, Bangkok, Thailand.
FAU - Soponkanaporn, Sirisucha
AU  - Soponkanaporn S
AD  - Division of Allergy, Immunology, and Rheumatology, Department of Pediatrics, 
      Mahidol University, Bangkok, Thailand.
FAU - Jaovisidha, Suphaneewan
AU  - Jaovisidha S
AD  - Department of Radiology, Faculty of Medicine, Ramathibodi Hospital, Mahidol 
      University, Bangkok, Thailand.
FAU - Benjaponpitak, Suwat
AU  - Benjaponpitak S
AD  - Division of Allergy, Immunology, and Rheumatology, Department of Pediatrics, 
      Mahidol University, Bangkok, Thailand.
FAU - Manuyakorn, Wiparat
AU  - Manuyakorn W
AD  - Division of Allergy, Immunology, and Rheumatology, Department of Pediatrics, 
      Mahidol University, Bangkok, Thailand.
LA  - eng
PT  - Journal Article
DEP - 20150714
PL  - England
TA  - Int J Rheum Dis
JT  - International journal of rheumatic diseases
JID - 101474930
RN  - 0 (Antirheumatic Agents)
RN  - 0 (Biological Products)
SB  - IM
MH  - Adolescent
MH  - Antirheumatic Agents/adverse effects/*therapeutic use
MH  - Arthritis, Juvenile/diagnosis/*drug therapy/physiopathology
MH  - Biological Products/adverse effects/*therapeutic use
MH  - Child
MH  - Early Diagnosis
MH  - Female
MH  - Health Status
MH  - Humans
MH  - Male
MH  - Predictive Value of Tests
MH  - Recovery of Function
MH  - Remission Induction
MH  - Retrospective Studies
MH  - Severity of Illness Index
MH  - Thailand
MH  - Time Factors
MH  - Treatment Outcome
OTO - NOTNLM
OT  - HLA-B27
OT  - bone erosions
OT  - juvenile idiopathic arthritis
OT  - outcomes
OT  - predictors
EDAT- 2015/07/16 06:00
MHDA- 2017/10/24 06:00
CRDT- 2015/07/16 06:00
PHST- 2015/07/16 06:00 [pubmed]
PHST- 2017/10/24 06:00 [medline]
PHST- 2015/07/16 06:00 [entrez]
AID - 10.1111/1756-185X.12637 [doi]
PST - ppublish
SO  - Int J Rheum Dis. 2016 Dec;19(12):1342-1350. doi: 10.1111/1756-185X.12637. Epub 
      2015 Jul 14.