PMID- 26176710
OWN - NLM
STAT- MEDLINE
DCOM- 20161024
LR  - 20220409
IS  - 1478-3231 (Electronic)
IS  - 1478-3223 (Linking)
VI  - 36
IP  - 2
DP  - 2016 Feb
TI  - The impact of non-alcoholic fatty liver disease on incident type 2 diabetes 
      mellitus in non-overweight individuals.
PG  - 275-83
LID - 10.1111/liv.12912 [doi]
AB  - BACKGROUND & AIMS: The aim of this study was to evaluate the impact of 
      non-alcoholic fatty liver disease (NAFLD) on incident type 2 diabetes mellitus 
      (T2DM) in non-overweight individuals with NAFLD. METHODS: A population-based 
      retrospective cohort study of 4629 participants who were enrolled in a health 
      check-up programme for more than 10 years. A standardized questionnaire and 
      abdominal ultrasonography were used to diagnose NAFLD. A cut-off point of BMI 23 
      kg/m(2) was used to define overweight (>/=23.0 kg/m(2)) or non-overweight (<23.0 
      kg/m(2)). The primary outcome was incident T2DM. RESULTS: Over a mean follow-up 
      of 12.8 years, 351 participants (7.6%) developed T2DM. The incidence rate of T2DM 
      was 3.2% in the non-overweight without NAFLD group, 14.4% in the non-overweight 
      with NAFLD group, 8.0% in the overweight without NAFLD group and 26.4% in the 
      overweight with NAFLD group. The adjusted hazard ratios for incident T2DM 
      compared with the non-overweight without NAFLD group were as follows: 3.59 (95% 
      CI: 2.14-5.76) in the non-overweight with NAFLD group, 1.99 (95% CI: 1.47-2.69) 
      in the overweight without NAFLD group and 6.77 (95% CI: 5.17-8.91) in the 
      overweight with NAFLD group. The adjusted hazard ratio in the non-overweight with 
      NAFLD group was significantly higher than that in the overweight without NAFLD 
      group or that in the non-overweight without NAFLD group. CONCLUSIONS: 
      Non-overweight individuals with NAFLD had a high risk of incident T2DM. Diagnosis 
      of NAFLD is important in non-overweight individuals, and therefore it might be 
      necessary to follow their health conditions on a long-term basis after detection 
      of NAFLD.
CI  - (c) 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Fukuda, Takuya
AU  - Fukuda T
AD  - Department of Endocrinology and Metabolism, Kyoto Prefectural University of 
      Medicine, Graduate School of Medical Science, Kyoto, Japan.
FAU - Hamaguchi, Masahide
AU  - Hamaguchi M
AUID- ORCID: 0000-0002-8651-4445
AD  - Department of Endocrinology and Metabolism, Kyoto Prefectural University of 
      Medicine, Graduate School of Medical Science, Kyoto, Japan.
FAU - Kojima, Takao
AU  - Kojima T
AD  - Department of Gastroenterology, Murakami Memorial Hospital, Asahi University, 
      Gifu, Japan.
FAU - Hashimoto, Yoshitaka
AU  - Hashimoto Y
AD  - Department of Endocrinology and Metabolism, Kyoto Prefectural University of 
      Medicine, Graduate School of Medical Science, Kyoto, Japan.
FAU - Ohbora, Akihiro
AU  - Ohbora A
AD  - Department of Gastroenterology, Murakami Memorial Hospital, Asahi University, 
      Gifu, Japan.
FAU - Kato, Takahiro
AU  - Kato T
AD  - Department of Internal Medicine, Aiseikai Yamashina Hospital, Kyoto, Japan.
FAU - Nakamura, Naoto
AU  - Nakamura N
AD  - Department of Endocrinology and Metabolism, Kyoto Prefectural University of 
      Medicine, Graduate School of Medical Science, Kyoto, Japan.
FAU - Fukui, Michiaki
AU  - Fukui M
AD  - Department of Endocrinology and Metabolism, Kyoto Prefectural University of 
      Medicine, Graduate School of Medical Science, Kyoto, Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150730
PL  - United States
TA  - Liver Int
JT  - Liver international : official journal of the International Association for the 
      Study of the Liver
JID - 101160857
SB  - IM
CIN - Liver Int. 2016 Mar;36(3):461. PMID: 26386230
CIN - Liver Int. 2016 Mar;36(3):462. PMID: 26442842
MH  - Adult
MH  - Body Mass Index
MH  - *Diabetes Mellitus, Type 2/diagnosis/epidemiology/etiology
MH  - Female
MH  - Humans
MH  - Incidence
MH  - Japan/epidemiology
MH  - Liver/*diagnostic imaging
MH  - Male
MH  - Middle Aged
MH  - *Non-alcoholic Fatty Liver Disease/complications/diagnosis/epidemiology
MH  - Proportional Hazards Models
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Ultrasonography
OTO - NOTNLM
OT  - cohort study
OT  - diabetes
OT  - epidemiology
OT  - liver disease
OT  - non-alcoholic fatty liver
EDAT- 2015/07/16 06:00
MHDA- 2016/10/25 06:00
CRDT- 2015/07/16 06:00
PHST- 2015/04/14 00:00 [received]
PHST- 2015/07/06 00:00 [accepted]
PHST- 2015/07/16 06:00 [entrez]
PHST- 2015/07/16 06:00 [pubmed]
PHST- 2016/10/25 06:00 [medline]
AID - 10.1111/liv.12912 [doi]
PST - ppublish
SO  - Liver Int. 2016 Feb;36(2):275-83. doi: 10.1111/liv.12912. Epub 2015 Jul 30.