PMID- 26177027
OWN - NLM
STAT- MEDLINE
DCOM- 20160609
LR  - 20220311
IS  - 1755-5922 (Electronic)
IS  - 1755-5914 (Linking)
VI  - 33
IP  - 5
DP  - 2015 Oct
TI  - Effects of the Galanin Receptor Antagonist M40 on Cardiac Function and Remodeling 
      in Rats with Heart Failure.
PG  - 288-93
LID - 10.1111/1755-5922.12144 [doi]
AB  - BACKGROUND: Sympathetic activation and parasympathetic withdrawal are important 
      characteristics of heart failure. Recent studies demonstrate that galanin reduces 
      the discharge of acetylcholine and inhibits vagal bradycardia by acting on 
      galanin receptor type 1 (GalR1). We speculated that blocking GalR1 is beneficial 
      for heart failure. METHODS: Rats with heart failure were induced by myocardial 
      infarction. The rats were injected intraperitoneally with galanin receptor 
      antagonist M40 solution (30 nmol/kg) or saline for 4 weeks. Cardiac function was 
      assessed by echocardiography and brain natriuretic peptide (BNP) in plasma. The 
      ratio of heart weight to body weight (HW/BW), hematoxylin-eosin (HE), and Masson 
      trichrome stain was used to evaluate cardiac remodeling. Tumor necrosis factor-alpha 
      (TNF-alpha), interleukin 6 (IL-6) in plasma, and sarco(endo)plasmic reticulum Ca(2+) 
      -ATPase (SERCA2) in heart tissue were detected to confirm the mechanism of the 
      cardioprotection effect. RESULTS: Compared with rats injected with saline, M40 
      effectively improved cardiac function of contraction; decreased BNP, IL-6, and 
      HW/BW (all P < 0.05); attenuated cardiac fibrosis; and upregulated SERCA2 
      (P < 0.05). CONCLUSION: M40 improves cardiac function and attenuates remodeling, 
      suggesting that galanin receptor antagonist may be a potential therapeutic agent 
      for HF.
CI  - (c) 2015 John Wiley & Sons Ltd.
FAU - Chen, Ao
AU  - Chen A
AD  - Department of Cardiology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong 
      University, Shanghai, China.
FAU - Li, Min
AU  - Li M
AD  - Department of Cardiology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong 
      University, Shanghai, China.
FAU - Song, Lei
AU  - Song L
AD  - Department of Cardiology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong 
      University, Shanghai, China.
FAU - Zhang, Yunhe
AU  - Zhang Y
AD  - Department of Cardiology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong 
      University, Shanghai, China.
FAU - Luo, Zhangyuan
AU  - Luo Z
AD  - Jie Sheng (Shanghai) Biological Technology Co., Ltd, Shanghai, China.
FAU - Zhang, Wenzan
AU  - Zhang W
AD  - Jie Sheng (Shanghai) Biological Technology Co., Ltd, Shanghai, China.
FAU - Chen, Yingmin
AU  - Chen Y
AD  - Department of Cardiology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong 
      University, Shanghai, China.
FAU - He, Ben
AU  - He B
AD  - Department of Cardiology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong 
      University, Shanghai, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Cardiovasc Ther
JT  - Cardiovascular therapeutics
JID - 101319630
RN  - 0 (Cardiotonic Agents)
RN  - 0 (Coloring Agents)
RN  - 0 (Interleukin-6)
RN  - 0 (M40)
RN  - 0 (Peptide Fragments)
RN  - 0 (Receptors, Galanin)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
RN  - 88813-36-9 (Galanin)
RN  - EC 3.6.3.8 (Sarcoplasmic Reticulum Calcium-Transporting ATPases)
RN  - EC 7.2.2.10 (ATP2A2 protein, human)
SB  - IM
MH  - Animals
MH  - Cardiotonic Agents/*pharmacology
MH  - Coloring Agents
MH  - Disease Models, Animal
MH  - Electrocardiography
MH  - Endomyocardial Fibrosis/prevention & control
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Galanin/*pharmacology
MH  - Heart Failure/*physiopathology
MH  - Interleukin-6/blood
MH  - Male
MH  - Myocardium/pathology
MH  - Natriuretic Peptide, Brain/blood
MH  - Organ Size
MH  - Peptide Fragments/*pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptors, Galanin/*antagonists & inhibitors
MH  - Sarcoplasmic Reticulum Calcium-Transporting ATPases/biosynthesis
MH  - Tumor Necrosis Factor-alpha
MH  - Ventricular Remodeling/*drug effects
OTO - NOTNLM
OT  - Antagonist
OT  - Cardiac function
OT  - Galanin
OT  - Heart failure
OT  - M40
OT  - Remodeling
EDAT- 2015/07/16 06:00
MHDA- 2016/06/10 06:00
CRDT- 2015/07/16 06:00
PHST- 2015/07/16 06:00 [entrez]
PHST- 2015/07/16 06:00 [pubmed]
PHST- 2016/06/10 06:00 [medline]
AID - 10.1111/1755-5922.12144 [doi]
PST - ppublish
SO  - Cardiovasc Ther. 2015 Oct;33(5):288-93. doi: 10.1111/1755-5922.12144.