PMID- 26177109
OWN - NLM
STAT- MEDLINE
DCOM- 20160520
LR  - 20191210
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 10
IP  - 7
DP  - 2015
TI  - Combined Scintigraphy and Tumor Marker Analysis Predicts Unfavorable 
      Histopathology of Neuroblastic Tumors with High Accuracy.
PG  - e0132809
LID - 10.1371/journal.pone.0132809 [doi]
LID - e0132809
AB  - OBJECTIVES: Our aim was to improve the prediction of unfavorable histopathology 
      (UH) in neuroblastic tumors through combined imaging and biochemical parameters. 
      METHODS: 123I-MIBG SPECT and MRI was performed before surgical resection or 
      biopsy in 47 consecutive pediatric patients with neuroblastic tumor. 
      Semi-quantitative tumor-to-liver count-rate ratio (TLCRR), MRI tumor size and 
      margins, urine catecholamine and NSE blood levels of neuron specific enolase 
      (NSE) were recorded. Accuracy of single and combined variables for prediction of 
      UH was tested by ROC analysis with Bonferroni correction. RESULTS: 34 of 47 
      patients had UH based on the International Neuroblastoma Pathology Classification 
      (INPC). TLCRR and serum NSE both predicted UH with moderate accuracy. Optimal 
      cut-off for TLCRR was 2.0, resulting in 68% sensitivity and 100% specificity 
      (AUC-ROC 0.86, p < 0.001). Optimal cut-off for NSE was 25.8 ng/ml, resulting in 
      74% sensitivity and 85% specificity (AUC-ROC 0.81, p = 0.001). Combination of 
      TLCRR/NSE criteria reduced false negative findings from 11/9 to only five, with 
      improved sensitivity and specificity of 85% (AUC-ROC 0.85, p < 0.001). 
      CONCLUSION: Strong 123I-MIBG uptake and high serum level of NSE were each 
      predictive of UH. Combined analysis of both parameters improved the prediction of 
      UH in patients with neuroblastic tumor. MRI parameters and urine catecholamine 
      levels did not predict UH.
FAU - Fendler, Wolfgang Peter
AU  - Fendler WP
AD  - Department of Nuclear Medicine, Ludwig-Maximilians-University of Munich, Munich, 
      Germany.
FAU - Wenter, Vera
AU  - Wenter V
AD  - Department of Nuclear Medicine, Ludwig-Maximilians-University of Munich, Munich, 
      Germany.
FAU - Thornton, Henriette Ingrid
AU  - Thornton HI
AD  - Department of Nuclear Medicine, Ludwig-Maximilians-University of Munich, Munich, 
      Germany.
FAU - Ilhan, Harun
AU  - Ilhan H
AD  - Department of Nuclear Medicine, Ludwig-Maximilians-University of Munich, Munich, 
      Germany.
FAU - von Schweinitz, Dietrich
AU  - von Schweinitz D
AD  - Department of Pediatric Surgery, Ludwig-Maximilians-University of Munich, Munich, 
      Germany.
FAU - Coppenrath, Eva
AU  - Coppenrath E
AD  - Institute of Clinical Radiology, Ludwig-Maximilians-University of Munich, Munich, 
      Germany.
FAU - Schmid, Irene
AU  - Schmid I
AD  - Department of Pediatric Haematology and Oncology, Ludwig-Maximilians-University 
      of Munich, Munich, Germany.
FAU - Bartenstein, Peter
AU  - Bartenstein P
AD  - Department of Nuclear Medicine, Ludwig-Maximilians-University of Munich, Munich, 
      Germany.
FAU - Pfluger, Thomas
AU  - Pfluger T
AD  - Department of Nuclear Medicine, Ludwig-Maximilians-University of Munich, Munich, 
      Germany.
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
DEP - 20150715
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Biomarkers, Tumor)
RN  - 35MRW7B4AD (3-Iodobenzylguanidine)
SB  - IM
MH  - 3-Iodobenzylguanidine
MH  - Abdominal Neoplasms/*diagnostic imaging
MH  - Adolescent
MH  - Adult
MH  - Biomarkers, Tumor/*analysis
MH  - Child
MH  - Child, Preschool
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Neuroblastoma/*diagnostic imaging
MH  - Prognosis
MH  - Radionuclide Imaging/*methods
MH  - Retrospective Studies
MH  - Sensitivity and Specificity
MH  - Young Adult
PMC - PMC4503303
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2015/07/16 06:00
MHDA- 2016/05/21 06:00
PMCR- 2015/07/15
CRDT- 2015/07/16 06:00
PHST- 2015/04/06 00:00 [received]
PHST- 2015/06/18 00:00 [accepted]
PHST- 2015/07/16 06:00 [entrez]
PHST- 2015/07/16 06:00 [pubmed]
PHST- 2016/05/21 06:00 [medline]
PHST- 2015/07/15 00:00 [pmc-release]
AID - PONE-D-15-14833 [pii]
AID - 10.1371/journal.pone.0132809 [doi]
PST - epublish
SO  - PLoS One. 2015 Jul 15;10(7):e0132809. doi: 10.1371/journal.pone.0132809. 
      eCollection 2015.