PMID- 26177270
OWN - NLM
STAT- MEDLINE
DCOM- 20160503
LR  - 20221207
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 10
IP  - 7
DP  - 2015
TI  - APOE Effects on Default Mode Network in Chinese Cognitive Normal Elderly: 
      Relationship with Clinical Cognitive Performance.
PG  - e0133179
LID - 10.1371/journal.pone.0133179 [doi]
LID - e0133179
AB  - BACKGROUND: Functional connectivity in default mode network (DMN) may be changed 
      in Alzheimer's disease (AD) patients and related risk populations, such as 
      amnestic mild cognitive impairment (aMCI) patients and APOE epsilon4 carriers. 
      Exploring DMN changes and related behavioral performance of APOE epsilon4 population 
      might provide valuable evidence for better understanding the development of AD. 
      METHODS: Subjects were enrolled from a population-based cohort established in a 
      multi-center study in China. Forty-nine cognitive normal individuals were 
      enrolled after standardized cognitive evaluations, MRI examination and APOE 
      genotyping. Regions of interest (ROI)-based functional connectivity analyses were 
      performed, and voxel-based analyses were used to validate these findings. The 
      correlation between DMN functional connectivity and behavioral performance was 
      further evaluated between APOE epsilon4epsilon3 and epsilon3epsilon3 carriers. RESULTS: Comparing to epsilon3epsilon3 
      carriers, functional connectivity between left parahippocampal gyrus and right 
      superior frontal cortex (LPHC-R.Sup.F), left parahippocampal gyrus and medial 
      prefrontal cortex (ventral) (LPHC-vMPFC) were significantly increased in epsilon4epsilon3 
      carriers, while connectivity between cerebellar tonsils and retrosplenial was 
      decreased. LPHC-R.Sup.F connectivity was positively correlated with the changes 
      of delay recall from baseline to follow-up (r = 0.768, p = 0.009), while 
      LPHC-vMPFC connectivity had a positive correlation with MMSE at baseline (r = 
      0.356, p = 0.018), and a negative correlation with long-delayed recognition at 
      follow-up (r = -0.677, p = 0.031). Significantly increased functional 
      connectivity in vMPFC was confirmed in voxel-based analyses by taking LPHC as 
      seed region. CONCLUSION: APOE epsilon4 carriers present both increased and decreased 
      functional connectivity in DMN, which is correlated with clinical cognitive 
      performances. DMN changes might be an early sign for cognitive decline.
FAU - Song, Haiqing
AU  - Song H
AD  - Department of Neurology, Xuanwu Hospital Capital Medical University, Beijing, 
      China.
FAU - Long, Haixia
AU  - Long H
AD  - Institute of Automation, Chinese Academy of Sciences, Beijing, China.
FAU - Zuo, Xiumei
AU  - Zuo X
AD  - Department of Neurology, Xuanwu Hospital Capital Medical University, Beijing, 
      China.
FAU - Yu, Chunshui
AU  - Yu C
AD  - Department of Radiology, Xuanwu Hospital Capital Medical University, Beijing, 
      China.
FAU - Liu, Bing
AU  - Liu B
AD  - Institute of Automation, Chinese Academy of Sciences, Beijing, China.
FAU - Wang, Zhiqun
AU  - Wang Z
AD  - Department of Radiology, Xuanwu Hospital Capital Medical University, Beijing, 
      China.
FAU - Wang, Qi
AU  - Wang Q
AD  - Department of Neurology, Xuanwu Hospital Capital Medical University, Beijing, 
      China.
FAU - Wang, Fen
AU  - Wang F
AD  - Department of Neurology, Xuanwu Hospital Capital Medical University, Beijing, 
      China.
FAU - Han, Ying
AU  - Han Y
AD  - Department of Neurology, Xuanwu Hospital Capital Medical University, Beijing, 
      China.
FAU - Jia, Jianping
AU  - Jia J
AD  - Department of Neurology, Xuanwu Hospital Capital Medical University, Beijing, 
      China.
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20150715
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Apolipoproteins E)
SB  - IM
MH  - Aged
MH  - Apolipoproteins E/*metabolism
MH  - *Asian People
MH  - Brain Mapping
MH  - *Cognition
MH  - Demography
MH  - Female
MH  - Frontal Lobe/physiopathology
MH  - Heterozygote
MH  - Humans
MH  - Male
MH  - Nerve Net/pathology/*physiopathology
PMC - PMC4503593
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2015/07/16 06:00
MHDA- 2016/05/04 06:00
PMCR- 2015/07/15
CRDT- 2015/07/16 06:00
PHST- 2015/03/07 00:00 [received]
PHST- 2015/06/23 00:00 [accepted]
PHST- 2015/07/16 06:00 [entrez]
PHST- 2015/07/16 06:00 [pubmed]
PHST- 2016/05/04 06:00 [medline]
PHST- 2015/07/15 00:00 [pmc-release]
AID - PONE-D-15-09669 [pii]
AID - 10.1371/journal.pone.0133179 [doi]
PST - epublish
SO  - PLoS One. 2015 Jul 15;10(7):e0133179. doi: 10.1371/journal.pone.0133179. 
      eCollection 2015.