PMID- 26178850
OWN - NLM
STAT- MEDLINE
DCOM- 20151030
LR  - 20161109
IS  - 0065-2598 (Print)
IS  - 0065-2598 (Linking)
VI  - 868
DP  - 2015
TI  - Human Leukocyte Antigen-G Within the Male Reproductive System: Implications for 
      Reproduction.
PG  - 171-90
LID - 10.1007/978-3-319-18881-2_8 [doi]
AB  - In sexual reproduction in humans, a man has a clear interest in ensuring that the 
      immune system of his female partner accepts the semi-allogenic fetus. Increasing 
      attention has been given to soluble immunomodulatory molecules in the seminal 
      fluid as one mechanism of ensuring this, possibly by "priming" the woman's immune 
      system before conception and at conception. Recent studies have demonstrated the 
      presence of the immunoregulatory and tolerance-inducible human leukocyte antigen 
      (HLA)-G in the male reproductive organs. The expression of HLA-G in the 
      blastocyst and by extravillous trophoblast cells in the placenta during pregnancy 
      has been well described. Highly variable amounts of soluble HLA-G (sHLA-G) in 
      seminal plasma from different men have been reported, and the concentration of 
      sHLA-G is associated with HLA-G genotype. A first pilot study indicates that the 
      level of sHLA-G in seminal plasma may even be associated with the chance of 
      pregnancy in couples, where the male partner has reduced semen quality. More 
      studies are needed to verify these preliminary findings.
FAU - Hviid, Thomas Vauvert F
AU  - Hviid TV
AD  - Department of Clinical Biochemistry, Centre for Immune Regulation and 
      Reproductive Immunology (CIRRI), Roskilde Hospital, Copenhagen University 
      Hospital (Roskilde), University of Copenhagen, 7-13 Kogevej, 4000, Roskilde, 
      Denmark, tvh@regionsjaelland.dk.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Adv Exp Med Biol
JT  - Advances in experimental medicine and biology
JID - 0121103
RN  - 0 (HLA-G Antigens)
SB  - IM
MH  - Female
MH  - Genitalia, Male/*physiology
MH  - HLA-G Antigens/genetics/*physiology
MH  - Humans
MH  - Male
MH  - Polymorphism, Genetic
MH  - Pregnancy
MH  - *Reproduction
EDAT- 2015/07/17 06:00
MHDA- 2015/10/31 06:00
CRDT- 2015/07/17 06:00
PHST- 2015/07/17 06:00 [entrez]
PHST- 2015/07/17 06:00 [pubmed]
PHST- 2015/10/31 06:00 [medline]
AID - 10.1007/978-3-319-18881-2_8 [doi]
PST - ppublish
SO  - Adv Exp Med Biol. 2015;868:171-90. doi: 10.1007/978-3-319-18881-2_8.