PMID- 26179524
OWN - NLM
STAT- MEDLINE
DCOM- 20160301
LR  - 20220321
IS  - 1349-7235 (Electronic)
IS  - 0918-2918 (Linking)
VI  - 54
IP  - 14
DP  - 2015
TI  - Dynamic Cerebrospinal Fluid Flow on MRI in Cortical Cerebellar Atrophy and 
      Multiple System Atrophy-cerebellar Type.
PG  - 1717-23
LID - 10.2169/internalmedicine.54.4747 [doi]
AB  - OBJECTIVE: The purpose of this study was to examine a new MRI technology, dynamic 
      cerebrospinal fluid (CSF) flow, to examine sporadic cerebellar ataxia patients 
      with cortical cerebellar atrophy (CCA) and multiple system atrophy-cerebellar 
      type (MSA-C). METHODS: Nine CCA patients (3 men and 6 women; mean age: 64.2+/-6.9 
      years) and 31 MSA-C patients (13 men and 18 women; mean age: 62.7+/-6.8 years) were 
      examined by a dynamic CSF flow analysis. All CSF flow data were evaluated by 
      phase contrast-MRI using a 1.5T MRI scanner. The CSF flow was calculated by 15 
      images in the equidistant MRI sequence which was taken through a cardiac cycle. 
      RESULTS: Compared with the CCA patients, the absolute values of the mean velocity 
      of the MSA-C patients were significantly reduced at time points 5 (CCA, 0.24+/-0.14 
      cm/s; MSA-C, 0.13+/-0.11 cm/s; (*) p<0.05) and 13 (CCA, -0.60+/-0.37 cm/s; MSA-C, 
      -0.31+/-0.17 cm/s; (**) p<0.01). Significant correlations in Spearman's rank 
      correlation coefficient were also found in MSA-C patients between the disease 
      duration and the difference between the maximum and minimum velocities (Vheight) 
      (r=-0.429, (*) p<0.05), the minimum velocity of the CSF (Vmin) (r=0.486, (**) 
      p<0.01) or the length of the minor axis of the pons (r=-0.529, (**) p<0.01). The 
      linear regressions between the disease duration and Vheight or Vmin revealed a 
      significant strong correlation only in the MSA-C patients. CONCLUSION: The 
      present CSF flow study showed for the first time that Vheight and Vmin revealed 
      good correlations with the disease duration in the MSA-C patients. Furthermore, 
      the velocity of the prepontine CSF flow tended to decrease in the MSA-C patients 
      compared with the CCA patients, suggesting that this particular CSF flow analysis 
      may be a new surrogate marker for differentiating both types of cerebellar 
      ataxia.
FAU - Fukui, Yusuke
AU  - Fukui Y
AD  - Department of Neurology, Graduate School of Medicine, Dentistry and 
      Pharmaceutical Sciences, Okayama University, Japan.
FAU - Hishikawa, Nozomi
AU  - Hishikawa N
FAU - Sato, Kota
AU  - Sato K
FAU - Kono, Syoichiro
AU  - Kono S
FAU - Matsuzono, Kosuke
AU  - Matsuzono K
FAU - Nakano, Yumiko
AU  - Nakano Y
FAU - Ohta, Yasuyuki
AU  - Ohta Y
FAU - Yamashita, Toru
AU  - Yamashita T
FAU - Deguchi, Kentaro
AU  - Deguchi K
FAU - Abe, Koji
AU  - Abe K
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150715
PL  - Japan
TA  - Intern Med
JT  - Internal medicine (Tokyo, Japan)
JID - 9204241
SB  - IM
MH  - Cerebellar Ataxia/pathology
MH  - Cerebellum/*pathology
MH  - Female
MH  - Humans
MH  - *Magnetic Resonance Imaging/methods
MH  - Male
MH  - Middle Aged
MH  - Multiple System Atrophy/*pathology
MH  - Pons/pathology
EDAT- 2015/07/17 06:00
MHDA- 2016/03/02 06:00
CRDT- 2015/07/17 06:00
PHST- 2015/07/17 06:00 [entrez]
PHST- 2015/07/17 06:00 [pubmed]
PHST- 2016/03/02 06:00 [medline]
AID - 10.2169/internalmedicine.54.4747 [doi]
PST - ppublish
SO  - Intern Med. 2015;54(14):1717-23. doi: 10.2169/internalmedicine.54.4747. Epub 2015 
      Jul 15.