PMID- 26182979
OWN - NLM
STAT- MEDLINE
DCOM- 20161213
LR  - 20161230
IS  - 1878-4046 (Electronic)
IS  - 1076-6332 (Linking)
VI  - 22
IP  - 9
DP  - 2015 Sep
TI  - Apparent diffusion coefficient maps integrated in whole-body MRI examination for 
      the evaluation of tumor response to chemotherapy in patients with multiple 
      myeloma.
PG  - 1163-71
LID - S1076-6332(15)00249-4 [pii]
LID - 10.1016/j.acra.2015.05.011 [doi]
AB  - RATIONALE AND OBJECTIVES: To determine the diagnostic value of apparent diffusion 
      coefficient (ADC) maps in the assessment of response to chemotherapy in patients 
      with multiple myeloma (MM). MATERIALS AND METHODS: Fourteen patients (seven 
      women) with MM underwent whole-body magnetic resonance imaging (WB-MRI) study on 
      a 1.5T scanner, before and after chemotherapy. DWI with background body signal 
      suppression (DWIBS) sequences (b values: 0, 500, and 1000 mm(2)/sec) were 
      qualitatively analyzed, along with T1 turbo spine echo and short tau inversion 
      recovery T2-weighted images, to evaluate bone lesions. On ADC maps, regions of 
      interest were manually drawn along contours of lesions. The ADC values percentage 
      variation (DeltaADC) before (MR1) and after (MR2) chemotherapy were calculated and 
      compared between responders (11 of 14) and nonresponders (3 of 14). The 
      percentage of plasma cells by the means of the bone marrow aspirate was evaluated 
      as parameter for response to chemotherapy. RESULTS: Twenty-four lesions, 
      hyperintense on DWIBS as compared to normal bone marrow, were evaluated. In 
      responder group, the mean ADC values were 0.63 +/- 0.24 x 10(-3) mm(2)/s on MR1 and 
      1.04 +/- 0.46 x 10(-3) mm(2)/s on MR2; partial or complete signal intensity 
      decrease during follow-up on DWIBS was found along with a reduction of plasma 
      cells infiltration in the bone marrow. The mean ADC values for nonresponders were 
      0.61 +/- 0.05 x 10(-3) mm(2)/s on MR1 and 0.69 +/- 0.09 x 10(-3) mm(2)/s on MR2. The 
      mean variation of DeltaADC in responders (Delta = 66%) was significantly different (P < 
      .05) than in nonresponders (Delta = 15%). CONCLUSIONS: WB-MRI with DWIBS sequences, 
      by evaluating posttreatment changes of ADC values, might represent a 
      complementary diagnostic tool in the assessment of response to chemotherapy in MM 
      patients.
CI  - Copyright (c) 2015 AUR. Published by Elsevier Inc. All rights reserved.
FAU - Bonaffini, Pietro Andrea
AU  - Bonaffini PA
AD  - School of Medicine, University of Milano-Bicocca, Via Pergolesi 33, 20900 Monza, 
      Italy; Department of Diagnostic Radiology, H. San Gerardo, Monza, Italy; 
      Department of Health Sciences, Tecnomed Foundation, University of Milano-Bicocca, 
      Monza, Italy. Electronic address: pa.bonaffini@gmail.com.
FAU - Ippolito, Davide
AU  - Ippolito D
AD  - School of Medicine, University of Milano-Bicocca, Via Pergolesi 33, 20900 Monza, 
      Italy; Department of Diagnostic Radiology, H. San Gerardo, Monza, Italy.
FAU - Casiraghi, Alessandra
AU  - Casiraghi A
AD  - School of Medicine, University of Milano-Bicocca, Via Pergolesi 33, 20900 Monza, 
      Italy; Department of Diagnostic Radiology, H. San Gerardo, Monza, Italy.
FAU - Besostri, Valeria
AU  - Besostri V
AD  - School of Medicine, University of Milano-Bicocca, Via Pergolesi 33, 20900 Monza, 
      Italy; Department of Diagnostic Radiology, H. San Gerardo, Monza, Italy.
FAU - Franzesi, Cammillo Talei
AU  - Franzesi CT
AD  - School of Medicine, University of Milano-Bicocca, Via Pergolesi 33, 20900 Monza, 
      Italy; Department of Diagnostic Radiology, H. San Gerardo, Monza, Italy.
FAU - Sironi, Sandro
AU  - Sironi S
AD  - School of Medicine, University of Milano-Bicocca, Via Pergolesi 33, 20900 Monza, 
      Italy; Department of Diagnostic Radiology, H. San Gerardo, Monza, Italy.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20150714
PL  - United States
TA  - Acad Radiol
JT  - Academic radiology
JID - 9440159
SB  - IM
MH  - Adult
MH  - Aged
MH  - Antineoplastic Combined Chemotherapy Protocols/therapeutic use
MH  - Bone Marrow Cells/drug effects
MH  - Cell Count
MH  - Diffusion Magnetic Resonance Imaging/*methods
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Image Enhancement/*methods
MH  - Image Processing, Computer-Assisted/methods
MH  - Male
MH  - Middle Aged
MH  - Multiple Myeloma/diagnostic imaging/*drug therapy
MH  - Neoplasm Staging
MH  - Plasma Cells/drug effects
MH  - Remission Induction
MH  - Whole Body Imaging/*methods
OTO - NOTNLM
OT  - ADC
OT  - Multiple myeloma
OT  - chemotherapy
OT  - whole-body MRI
EDAT- 2015/07/18 06:00
MHDA- 2016/12/15 06:00
CRDT- 2015/07/18 06:00
PHST- 2014/11/23 00:00 [received]
PHST- 2015/05/26 00:00 [revised]
PHST- 2015/05/27 00:00 [accepted]
PHST- 2015/07/18 06:00 [entrez]
PHST- 2015/07/18 06:00 [pubmed]
PHST- 2016/12/15 06:00 [medline]
AID - S1076-6332(15)00249-4 [pii]
AID - 10.1016/j.acra.2015.05.011 [doi]
PST - ppublish
SO  - Acad Radiol. 2015 Sep;22(9):1163-71. doi: 10.1016/j.acra.2015.05.011. Epub 2015 
      Jul 14.