PMID- 26183169
OWN - NLM
STAT- MEDLINE
DCOM- 20160126
LR  - 20220317
IS  - 2092-6413 (Electronic)
IS  - 1226-3613 (Print)
IS  - 1226-3613 (Linking)
VI  - 47
IP  - 7
DP  - 2015 Jul 17
TI  - Acute exposure to silica nanoparticles aggravate airway inflammation: different 
      effects according to surface characteristics.
PG  - e173
LID - 10.1038/emm.2015.50 [doi]
AB  - Silica nanoparticles (SNPs) are widely used in many scientific and industrial 
      fields despite the lack of proper evaluation of their potential toxicity. This 
      study examined the effects of acute exposure to SNPs, either alone or in 
      conjunction with ovalbumin (OVA), by studying the respiratory systems in exposed 
      mouse models. Three types of SNPs were used: spherical SNPs (S-SNPs), mesoporous 
      SNPs (M-SNPs), and PEGylated SNPs (P-SNPs). In the acute SNP exposure model 
      performed, 6-week-old BALB/c female mice were intranasally inoculated with SNPs 
      for 3 consecutive days. In the OVA/SNPs asthma model, the mice were sensitized 
      two times via the peritoneal route with OVA. Additionally, the mice endured OVA 
      with or without SNP challenges intranasally. Acute SNP exposure induced 
      significant airway inflammation and airway hyper-responsiveness, particularly in 
      the S-SNP group. In OVA/SNPs asthma models, OVA with SNP-treated group showed 
      significant airway inflammation, more than those treated with only OVA and 
      without SNPs. In these models, the P-SNP group induced lower levels of 
      inflammation on airways than both the S-SNP or M-SNP groups. Interleukin (IL)-5, 
      IL-13, IL-1beta and interferon-gamma levels correlated with airway inflammation in the 
      tested models, without statistical significance. In the mouse models studied, 
      increased airway inflammation was associated with acute SNPs exposure, whether 
      exposed solely to SNPs or SNPs in conjunction with OVA. P-SNPs appear to be 
      relatively safer for clinical use than S-SNPs and M-SNPs, as determined by lower 
      observed toxicity and airway system inflammation.
FAU - Park, Hye Jung
AU  - Park HJ
AD  - Division of Allergy and Immunology, Department of Internal Medicine, Yonsei 
      University College of Medicine, Severance Hospital, Seoul, Korea.
FAU - Sohn, Jung-Ho
AU  - Sohn JH
AD  - 1] Division of Allergy and Immunology, Department of Internal Medicine, Yonsei 
      University College of Medicine, Severance Hospital, Seoul, Korea [2] Department 
      of Life Science, Research Institute for Natural Sciences, Hanyang Biomedical 
      Research Institute, Hanyang University, Seoul, Korea.
FAU - Kim, Yoon-Ju
AU  - Kim YJ
AD  - Division of Allergy and Immunology, Department of Internal Medicine, Yonsei 
      University College of Medicine, Severance Hospital, Seoul, Korea.
FAU - Park, Yoon Hee
AU  - Park YH
AD  - Division of Allergy and Immunology, Department of Internal Medicine, Yonsei 
      University College of Medicine, Severance Hospital, Seoul, Korea.
FAU - Han, Heejae
AU  - Han H
AD  - Division of Allergy and Immunology, Department of Internal Medicine, Yonsei 
      University College of Medicine, Severance Hospital, Seoul, Korea.
FAU - Park, Kyung Hee
AU  - Park KH
AD  - Division of Allergy and Immunology, Department of Internal Medicine, Yonsei 
      University College of Medicine, Severance Hospital, Seoul, Korea.
FAU - Lee, Kangtaek
AU  - Lee K
AD  - Department of Chemical and Biomolecular Engineering, Yonsei University, Seoul, 
      Korea.
FAU - Choi, Hoon
AU  - Choi H
AD  - Department of Chemical and Biomolecular Engineering, Yonsei University, Seoul, 
      Korea.
FAU - Um, Kiju
AU  - Um K
AD  - Department of Chemical and Biomolecular Engineering, Yonsei University, Seoul, 
      Korea.
FAU - Choi, In-Hong
AU  - Choi IH
AD  - Department of Microbiology, Brain Korea 21 Project for Medical Science, Institute 
      for Immunology and Immunological Diseases, Yonsei University College of Medicine, 
      Seoul, Korea.
FAU - Park, Jung-Won
AU  - Park JW
AD  - Division of Allergy and Immunology, Department of Internal Medicine, Yonsei 
      University College of Medicine, Severance Hospital, Seoul, Korea.
FAU - Lee, Jae-Hyun
AU  - Lee JH
AD  - Division of Allergy and Immunology, Department of Internal Medicine, Yonsei 
      University College of Medicine, Severance Hospital, Seoul, Korea.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150717
PL  - United States
TA  - Exp Mol Med
JT  - Experimental & molecular medicine
JID - 9607880
RN  - 0 (Interleukins)
RN  - 3WJQ0SDW1A (Polyethylene Glycols)
RN  - 7631-86-9 (Silicon Dioxide)
RN  - 82115-62-6 (Interferon-gamma)
RN  - 9006-59-1 (Ovalbumin)
SB  - IM
MH  - Animals
MH  - Asthma/*chemically induced/pathology
MH  - Female
MH  - Inflammation/*chemically induced/pathology
MH  - Interferon-gamma/analysis
MH  - Interleukins/analysis
MH  - Lung/drug effects/*pathology
MH  - Mice, Inbred BALB C
MH  - Nanoparticles/*adverse effects/chemistry
MH  - Ovalbumin/adverse effects
MH  - Polyethylene Glycols/adverse effects/chemistry
MH  - Silicon Dioxide/*adverse effects/chemistry
MH  - Surface Properties
PMC - PMC4525300
EDAT- 2015/07/18 06:00
MHDA- 2016/01/27 06:00
PMCR- 2015/07/01
CRDT- 2015/07/18 06:00
PHST- 2015/01/06 00:00 [received]
PHST- 2015/05/26 00:00 [revised]
PHST- 2015/05/05 00:00 [accepted]
PHST- 2015/07/18 06:00 [entrez]
PHST- 2015/07/18 06:00 [pubmed]
PHST- 2016/01/27 06:00 [medline]
PHST- 2015/07/01 00:00 [pmc-release]
AID - emm201550 [pii]
AID - 10.1038/emm.2015.50 [doi]
PST - epublish
SO  - Exp Mol Med. 2015 Jul 17;47(7):e173. doi: 10.1038/emm.2015.50.