PMID- 26183340
OWN - NLM
STAT- MEDLINE
DCOM- 20160805
LR  - 20161125
IS  - 2040-3372 (Electronic)
IS  - 2040-3364 (Linking)
VI  - 7
IP  - 36
DP  - 2015 Sep 28
TI  - Pattern recognition of monocyte chemoattractant protein-1 (MCP-1) in whole blood 
      samples using new platforms based on nanostructured materials.
PG  - 14848-53
LID - 10.1039/c5nr03064a [doi]
AB  - Four stochastic microsensors based on nanostructured materials (graphene, 
      maltodextrin (MD), and diamond) integrated in miniaturized platforms were 
      proposed. Monocyte chemoattractant protein-1 (MCP-1) is a pro-inflammatory 
      cytokine whose main function is to regulate cell trafficking. It is correlated 
      with the incidence of cardiovascular diseases and obesity, and was used as the 
      model analyte in this study. The screening of whole blood samples for MCP-1 can 
      be done for concentrations ranging from 10(-12) to 10(-8) g mL(-1). The method 
      was used for both qualitative and quantitative assessments of MCP-1 in whole 
      blood samples. The lowest quantification limits for the assay of MCP-1 (1 pg 
      mL(-1)) were reached when the microsensors based on protoporphyrin 
      IX/Graphene-Au-3 and on MD/Graphene were employed in the platform design.
FAU - Stefan-van Staden, Raluca-Ioana
AU  - Stefan-van Staden RI
AD  - Laboratory of Electrochemistry and PATLAB, National Institute of Research for 
      Electrochemistry and Condensed Matter, 202 Splaiul Independentei Str., 060021, 
      Bucharest-6, Romania. ralucavanstaden@gmail.com.
FAU - Gugoasa, Livia Alexandra
AU  - Gugoasa LA
FAU - Biris, Alexandru Radu
AU  - Biris AR
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150717
PL  - England
TA  - Nanoscale
JT  - Nanoscale
JID - 101525249
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Protoporphyrins)
RN  - 7440-57-5 (Gold)
RN  - 7782-42-5 (Graphite)
RN  - C2K325S808 (protoporphyrin IX)
SB  - IM
MH  - Biosensing Techniques/*methods
MH  - Chemokine CCL2/*blood
MH  - Female
MH  - Gold/*chemistry
MH  - Graphite/*chemistry
MH  - Humans
MH  - Male
MH  - Nanostructures/*chemistry
MH  - Obesity/*blood
MH  - Protoporphyrins/*chemistry
EDAT- 2015/07/18 06:00
MHDA- 2016/08/06 06:00
CRDT- 2015/07/18 06:00
PHST- 2015/07/18 06:00 [entrez]
PHST- 2015/07/18 06:00 [pubmed]
PHST- 2016/08/06 06:00 [medline]
AID - 10.1039/c5nr03064a [doi]
PST - ppublish
SO  - Nanoscale. 2015 Sep 28;7(36):14848-53. doi: 10.1039/c5nr03064a. Epub 2015 Jul 17.