PMID- 26184485
OWN - NLM
STAT- MEDLINE
DCOM- 20161031
LR  - 20220419
IS  - 1708-8283 (Electronic)
IS  - 0883-0738 (Linking)
VI  - 31
IP  - 3
DP  - 2016 Mar
TI  - Role of Autoantibodies to N-Methyl-d-Aspartate (NMDA) Receptor in Relapsing 
      Herpes Simplex Encephalitis: A Retrospective, One-Center Experience.
PG  - 345-50
LID - 10.1177/0883073815595079 [doi]
AB  - Post-herpes simplex virus encephalitis relapses have been recently associated 
      with autoimmunity driven by autoantibodies against N-methyl-d-aspartate (NMDA) 
      receptors. Because it offers different treatment options, determination of this 
      condition is important. Between 2011 and 2014, 7 children with proven diagnosis 
      of herpes simplex virus encephalitis were identified in a university hospital of 
      Istanbul. Two patients had neurologic relapse characterized mainly by movement 
      disorders 2 to 3 weeks after initial encephalitis. The first patient received a 
      second 14 days of acyclovir treatment together with antiepileptic drugs and left 
      with severe neurologic sequelae. The second patient was found to be NMDA 
      receptors antibody positive in the cerebrospinal fluid. She was treated with 
      intravenous immunoglobulin and prednisolone. She showed substantial improvement, 
      gradually regaining lost neurologic abilities. Post-herpes simplex virus 
      encephalitis relapses may frequently be immune-mediated rather than a viral 
      reactivation, particularly in children displaying movement disorders like 
      choreoathetosis. Immunotherapy may provide benefit for this potentially 
      devastating condition, like the case described in this report.
CI  - (c) The Author(s) 2015.
FAU - Sutcu, Murat
AU  - Sutcu M
AD  - Department of Pediatric Infectious Diseases, Istanbul Medical Faculty, Istanbul 
      University, Istanbul, Turkey.
FAU - Akturk, Hacer
AU  - Akturk H
AD  - Department of Pediatric Infectious Diseases, Istanbul Medical Faculty, Istanbul 
      University, Istanbul, Turkey hacergunakturk@gmail.com.
FAU - Somer, Ayper
AU  - Somer A
AD  - Department of Pediatric Infectious Diseases, Istanbul Medical Faculty, Istanbul 
      University, Istanbul, Turkey.
FAU - Tatli, Burak
AU  - Tatli B
AD  - Department of Pediatric Neurology, Istanbul Medical Faculty, Istanbul University, 
      Istanbul, Turkey.
FAU - Torun, Selda Hancerli
AU  - Torun SH
AD  - Department of Pediatric Infectious Diseases, Istanbul Medical Faculty, Istanbul 
      University, Istanbul, Turkey.
FAU - Yildiz, Edibe Pembegul
AU  - Yildiz EP
AD  - Department of Pediatric Neurology, Istanbul Medical Faculty, Istanbul University, 
      Istanbul, Turkey.
FAU - Sik, Guntulu
AU  - Sik G
AD  - Department of Pediatric Intensive Care, Istanbul Medical Faculty, Istanbul 
      University, Istanbul, Turkey.
FAU - Citak, Agop
AU  - Citak A
AD  - Department of Pediatric Intensive Care, Istanbul Medical Faculty, Istanbul 
      University, Istanbul, Turkey.
FAU - Agacfidan, Ali
AU  - Agacfidan A
AD  - Department of Microbiology, Istanbul Medical Faculty, Istanbul University, 
      Istanbul, Turkey.
FAU - Salman, Nuran
AU  - Salman N
AD  - Department of Pediatric Infectious Diseases, Istanbul Medical Faculty, Istanbul 
      University, Istanbul, Turkey.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20150716
PL  - United States
TA  - J Child Neurol
JT  - Journal of child neurology
JID - 8606714
RN  - 0 (Autoantibodies)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
SB  - IM
MH  - Adolescent
MH  - Anti-N-Methyl-D-Aspartate Receptor Encephalitis/drug therapy/physiopathology
MH  - Autoantibodies/*metabolism
MH  - Child
MH  - Child, Preschool
MH  - Encephalitis, Herpes Simplex/drug therapy/*physiopathology
MH  - Female
MH  - Humans
MH  - Infant
MH  - Male
MH  - Receptors, N-Methyl-D-Aspartate/*immunology
MH  - Recurrence
MH  - Retrospective Studies
OTO - NOTNLM
OT  - NMDA receptor autoantibodies
OT  - autoimmunity
OT  - herpes encephalitis
OT  - relapsing herpes encephalitis
EDAT- 2015/07/18 06:00
MHDA- 2016/11/01 06:00
CRDT- 2015/07/18 06:00
PHST- 2015/03/18 00:00 [received]
PHST- 2015/06/10 00:00 [accepted]
PHST- 2015/07/18 06:00 [entrez]
PHST- 2015/07/18 06:00 [pubmed]
PHST- 2016/11/01 06:00 [medline]
AID - 0883073815595079 [pii]
AID - 10.1177/0883073815595079 [doi]
PST - ppublish
SO  - J Child Neurol. 2016 Mar;31(3):345-50. doi: 10.1177/0883073815595079. Epub 2015 
      Jul 16.