PMID- 26184518
OWN - NLM
STAT- MEDLINE
DCOM- 20161020
LR  - 20181113
IS  - 1880-344X (Electronic)
IS  - 1349-0222 (Linking)
VI  - 13
IP  - 1
DP  - 2015 Mar
TI  - Prognostic significance of persistent restrictive filling pattern after cardiac 
      resynchronization therapy.
PG  - 20-6
LID - 10.1007/s12574-014-0234-0 [doi]
AB  - BACKGROUND: Cardiac resynchronization therapy (CRT) may improve left ventricular 
      (LV) diastolic dysfunction as well as systolic dysfunction. Diastolic dysfunction 
      is a key for prognosis in patients with heart failure; therefore, we aimed to 
      clarify the impact of CRT on diastolic function and prognosis. METHODS: In 67 
      patients who underwent CRT, LV diastolic function was assessed by pulsed Doppler 
      transmitral flow pattern at baseline and 1 week after CRT, and classified into 
      restrictive filling pattern (RFP) and non-RFP groups. Volume responders were 
      defined by reduction of LV end-systolic volume >15% at 6 months after CRT. The 
      clinical endpoint comprised death from any cause or unplanned hospitalization for 
      a major cardiovascular event (MACE). RESULTS: During the follow-up period (479 +/- 
      252 days), 26 patients (38.8%) had reached the endpoint of MACE. In Cox 
      proportional hazard analyses, RFP at 1 week after CRT was associated with the 
      endpoints independently of age and New York Heart Association (NYHA) class IV at 
      baseline. Thirty (44.8%) patients were identified as volume responders, who had 
      better prognosis than non-responders. Patients were classified into 4 groups 
      based on their filling pattern at 1 week after CRT and volume responses. The 
      worst prognosis was observed in the RFP and non-responder group, and the best was 
      observed in the non-RFP and responder group. For the remaining 2 groups with 
      intermediate prognosis, the RFP and responder group showed poorer prognosis 
      compared to the non-RFP and non-responder group. CONCLUSIONS: Persistent RFP 
      after CRT may be a strong prognostic predictor, which should be treated with more 
      intensive therapy to improve the prognosis of patients following CRT.
FAU - Yamamoto, Masayoshi
AU  - Yamamoto M
AD  - Cardiovascular Division, Faculty of Clinical Medicine, Institute of Clinical 
      Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 
      1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8575, Japan.
FAU - Seo, Yoshihiro
AU  - Seo Y
FAU - Ishizu, Tomoko
AU  - Ishizu T
FAU - Kawamatsu, Naoto
AU  - Kawamatsu N
FAU - Sato, Kimi
AU  - Sato K
FAU - Sugano, Akinori
AU  - Sugano A
FAU - Atsumi, Akiko
AU  - Atsumi A
FAU - Harimura, Yoshie
AU  - Harimura Y
FAU - Machino-Ohtsuka, Tomoko
AU  - Machino-Ohtsuka T
FAU - Sakamaki, Fumiko
AU  - Sakamaki F
FAU - Aonuma, Kazutaka
AU  - Aonuma K
LA  - eng
PT  - Journal Article
DEP - 20141203
PL  - Japan
TA  - J Echocardiogr
JT  - Journal of echocardiography
JID - 101263153
SB  - IM
MH  - Adult
MH  - Aged
MH  - *Cardiac Resynchronization Therapy
MH  - Diastole/*physiology
MH  - Echocardiography, Doppler, Pulsed
MH  - Female
MH  - Heart Failure/*therapy
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Prospective Studies
MH  - *Stroke Volume
MH  - Ventricular Dysfunction, Left/diagnostic imaging/*physiopathology
MH  - Ventricular Function, Left
EDAT- 2015/07/18 06:00
MHDA- 2016/10/21 06:00
CRDT- 2015/07/18 06:00
PHST- 2014/08/13 00:00 [received]
PHST- 2014/11/21 00:00 [accepted]
PHST- 2014/11/11 00:00 [revised]
PHST- 2015/07/18 06:00 [entrez]
PHST- 2015/07/18 06:00 [pubmed]
PHST- 2016/10/21 06:00 [medline]
AID - 10.1007/s12574-014-0234-0 [doi]
PST - ppublish
SO  - J Echocardiogr. 2015 Mar;13(1):20-6. doi: 10.1007/s12574-014-0234-0. Epub 2014 
      Dec 3.