PMID- 26184696
OWN - NLM
STAT- MEDLINE
DCOM- 20160609
LR  - 20150822
IS  - 1879-1484 (Electronic)
IS  - 0021-9150 (Linking)
VI  - 242
IP  - 1
DP  - 2015 Sep
TI  - Plasma cholesterol-lowering activity of dietary dihydrocholesterol in 
      hypercholesterolemia hamsters.
PG  - 77-86
LID - S0021-9150(15)30008-3 [pii]
LID - 10.1016/j.atherosclerosis.2015.06.046 [doi]
AB  - OBJECTIVE: Cholesterol analogs have been used to treat hypercholesterolemia. The 
      present study was to examine the effect of dihydrocholesterol (DC) on plasma 
      total cholesterol (TC) compared with that of beta-sitosterol (SI) in hamsters fed a 
      high cholesterol diet. METHODS AND RESULTS: Forty-five male hamsters were 
      randomly divided into 6 groups, fed either a non-cholesterol diet (NCD) or one of 
      five high-cholesterol diets without addition of DC and SI (HCD) or with addition 
      of 0.2% DC (DA), 0.3% DC (DB), 0.2% SI (SA), and 0.3% SI (SB), respectively, for 
      6 weeks. Results showed that DC added into diet at a dose of 0.2% could reduce 
      plasma TC by 21%, comparable to that of SI (19%). At a higher dose of 0.3%, DC 
      reduced plasma TC by 15%, less effective than SI (32%). Both DC and SI could 
      increase the excretion of fecal sterols, however, DC was more effective in 
      increasing the excretion of neutral sterols but it was less effective in 
      increasing the excretion of acidic sterols compared with SI. Results on the 
      incorporation of sterols in micellar solutions clearly demonstrated both DC and 
      SI could displace the cholesterol from micelles with the former being more 
      effective than the latter. CONCLUSION: DC was equally effective in reducing 
      plasma cholesterol as SI at a low dose. Plasma TC-lowering activity of DC was 
      mediated by inhibiting the cholesterol absorption and increasing the fecal sterol 
      excretion.
CI  - Copyright (c) 2015 Elsevier Ireland Ltd. All rights reserved.
FAU - Wang, Xiaobo
AU  - Wang X
AD  - Food & Nutritional Sciences Programme, School of Life Sciences, The Chinese 
      University of Hong Kong, Shatin, NT, Hong Kong, China.
FAU - Guan, Lei
AU  - Guan L
AD  - R&D, Nestle, Beijing 100022, China.
FAU - Zhao, Youyou
AU  - Zhao Y
AD  - R&D, Nestle, Beijing 100022, China.
FAU - Lei, Lin
AU  - Lei L
AD  - Food & Nutritional Sciences Programme, School of Life Sciences, The Chinese 
      University of Hong Kong, Shatin, NT, Hong Kong, China.
FAU - Liu, Yuwei
AU  - Liu Y
AD  - Food & Nutritional Sciences Programme, School of Life Sciences, The Chinese 
      University of Hong Kong, Shatin, NT, Hong Kong, China.
FAU - Ma, Ka Ying
AU  - Ma KY
AD  - Food & Nutritional Sciences Programme, School of Life Sciences, The Chinese 
      University of Hong Kong, Shatin, NT, Hong Kong, China.
FAU - Wang, Lijun
AU  - Wang L
AD  - Food & Nutritional Sciences Programme, School of Life Sciences, The Chinese 
      University of Hong Kong, Shatin, NT, Hong Kong, China.
FAU - Man, Sun Wa
AU  - Man SW
AD  - Food & Nutritional Sciences Programme, School of Life Sciences, The Chinese 
      University of Hong Kong, Shatin, NT, Hong Kong, China.
FAU - Wang, Junkuan
AU  - Wang J
AD  - R&D, Nestle, Beijing 100022, China.
FAU - Huang, Yu
AU  - Huang Y
AD  - School of Biomedical Sciences, Chinese University of Hong Kong, Shatin, NT, Hong 
      Kong, China.
FAU - Chen, Zhen-Yu
AU  - Chen ZY
AD  - Food & Nutritional Sciences Programme, School of Life Sciences, The Chinese 
      University of Hong Kong, Shatin, NT, Hong Kong, China. Electronic address: 
      zhenyuchen@cuhk.edu.hk.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20150627
PL  - Ireland
TA  - Atherosclerosis
JT  - Atherosclerosis
JID - 0242543
RN  - 0 (Anticholesteremic Agents)
RN  - 0 (Bile Acids and Salts)
RN  - 0 (Cholesterol, Dietary)
RN  - 0 (Lipids)
RN  - 0 (Lipoproteins)
RN  - 0 (Micelles)
RN  - 0 (RNA, Messenger)
RN  - 0 (Sitosterols)
RN  - 0 (Sterols)
RN  - 5LI01C78DD (gamma-sitosterol)
RN  - 8M308U816E (Cholestanol)
RN  - 97C5T2UQ7J (Cholesterol)
SB  - IM
MH  - Adipose Tissue/drug effects/pathology
MH  - Animal Feed/analysis
MH  - Animals
MH  - Anticholesteremic Agents/administration & dosage/*therapeutic use
MH  - Aortic Diseases/etiology/pathology/prevention & control
MH  - Atherosclerosis/etiology/pathology/prevention & control
MH  - Bile Acids and Salts/analysis
MH  - Cholestanol/administration & dosage/*therapeutic use
MH  - Cholesterol/*blood
MH  - Cholesterol, Dietary/administration & dosage/pharmacokinetics
MH  - Cricetinae
MH  - Drug Evaluation, Preclinical
MH  - Feces/chemistry
MH  - Gene Expression Profiling
MH  - Hyperlipoproteinemia Type II/blood/complications/*diet therapy
MH  - Intestinal Absorption/*drug effects
MH  - Lipids/blood
MH  - Lipoproteins/blood
MH  - Liver/chemistry/pathology
MH  - Male
MH  - Mesocricetus
MH  - Metabolic Networks and Pathways/genetics
MH  - Micelles
MH  - Molecular Structure
MH  - Organ Size/drug effects
MH  - Plaque, Atherosclerotic/pathology
MH  - RNA, Messenger/biosynthesis
MH  - Random Allocation
MH  - Sitosterols/administration & dosage/therapeutic use
MH  - Sterols/analysis
MH  - Viscera/drug effects/pathology
OTO - NOTNLM
OT  - 5alpha-cholestanol
OT  - Cholesterol
OT  - Sterol
OT  - beta-sitosterol
EDAT- 2015/07/18 06:00
MHDA- 2016/06/10 06:00
CRDT- 2015/07/18 06:00
PHST- 2015/02/25 00:00 [received]
PHST- 2015/06/19 00:00 [revised]
PHST- 2015/06/22 00:00 [accepted]
PHST- 2015/07/18 06:00 [entrez]
PHST- 2015/07/18 06:00 [pubmed]
PHST- 2016/06/10 06:00 [medline]
AID - S0021-9150(15)30008-3 [pii]
AID - 10.1016/j.atherosclerosis.2015.06.046 [doi]
PST - ppublish
SO  - Atherosclerosis. 2015 Sep;242(1):77-86. doi: 
      10.1016/j.atherosclerosis.2015.06.046. Epub 2015 Jun 27.