PMID- 26184813
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150827
LR  - 20200115
IS  - 2165-0497 (Print)
IS  - 2165-0497 (Linking)
VI  - 1
IP  - 1
DP  - 2013 Oct
TI  - Immunoglobulin E and Allergy: Antibodies in Immune Inflammation and Treatment.
LID - 10.1128/microbiolspec.AID-0006-2012 [doi]
AB  - The pathogenic role of immunoglobulin E (IgE) antibodies in triggering and 
      maintaining allergic inflammation in response to allergens is due to the binding 
      of multivalent allergens to allergen-specific IgEs on sensitized effector cells. 
      These interactions trigger effector cell activation, resulting in release of 
      potent inflammatory mediators, recruitment of inflammatory cells, antigen 
      presentation, and production of allergen-specific antibody responses. Since its 
      discovery in the 1960s, the central role of IgE in allergic disease has been 
      intensively studied, placing IgE and its functions at the heart of therapeutic 
      efforts for the treatment of allergies. Here, we provide an overview of the 
      nature, roles, and significance of IgE antibodies in allergic diseases, 
      infections, and inflammation and the utility of antibodies as therapies. We place 
      special emphasis on allergen-IgE-Fcepsilon receptor complexes in the context of 
      allergic and inflammatory diseases and describe strategies, including monoclonal 
      antibodies, aimed at interrupting these complexes. Of clinical significance, one 
      antibody, omalizumab, is presently in clinical use and works by preventing 
      formation of IgE-Fcepsilon receptor interactions. Active immunotherapy approaches with 
      allergens and allergen derivatives have also demonstrated clinical benefits for 
      patients with allergic diseases. These treatments are strongly associated with 
      serum increases of IgE-neutralizing antibodies and feature a notable redirection 
      of humoral responses towards production of antibodies of the IgG4 subclass in 
      patients receiving immunotherapies. Lastly, we provide a new perspective on the 
      rise of recombinant antibodies of the IgE class recognizing tumor-associated 
      antigens, and we discuss the potential utility of tumor antigen-specific IgE 
      antibodies to direct potent IgE-driven immune responses against tumors.
FAU - Karagiannis, Sophia N
AU  - Karagiannis SN
AD  - Cutaneous Medicine and Immunotherapy Unit, St. John's Institute of Dermatology, 
      Division of Genetics and Molecular Medicine & NIHR Biomedical Research Centre at 
      Guy's and St. Thomas's Hospitals and King's College London, King's College London 
      School of Medicine, Guy's Hospital, King's College London, London SE1 9RT, United 
      Kingdom.
FAU - Karagiannis, Panagiotis
AU  - Karagiannis P
AD  - Cutaneous Medicine and Immunotherapy Unit, St. John's Institute of Dermatology, 
      Division of Genetics and Molecular Medicine & NIHR Biomedical Research Centre at 
      Guy's and St. Thomas's Hospitals and King's College London, King's College London 
      School of Medicine, Guy's Hospital, King's College London, London SE1 9RT, United 
      Kingdom.
FAU - Josephs, Debra H
AU  - Josephs DH
AD  - Cutaneous Medicine and Immunotherapy Unit, St. John's Institute of Dermatology, 
      Division of Genetics and Molecular Medicine & NIHR Biomedical Research Centre at 
      Guy's and St. Thomas's Hospitals and King's College London, King's College London 
      School of Medicine, Guy's Hospital, King's College London, London SE1 9RT, United 
      Kingdom.
FAU - Saul, Louise
AU  - Saul L
AD  - Cutaneous Medicine and Immunotherapy Unit, St. John's Institute of Dermatology, 
      Division of Genetics and Molecular Medicine & NIHR Biomedical Research Centre at 
      Guy's and St. Thomas's Hospitals and King's College London, King's College London 
      School of Medicine, Guy's Hospital, King's College London, London SE1 9RT, United 
      Kingdom.
FAU - Gilbert, Amy E
AU  - Gilbert AE
AD  - Cutaneous Medicine and Immunotherapy Unit, St. John's Institute of Dermatology, 
      Division of Genetics and Molecular Medicine & NIHR Biomedical Research Centre at 
      Guy's and St. Thomas's Hospitals and King's College London, King's College London 
      School of Medicine, Guy's Hospital, King's College London, London SE1 9RT, United 
      Kingdom.
FAU - Upton, Nadine
AU  - Upton N
AD  - Randall Division of Cell and Molecular Biophysics, Division of Asthma, Allergy, 
      and Lung Biology, MRC and Asthma UK Centre for Allergic Mechanisms of Asthma, 
      King's College London, New Hunt's House, Guy's Campus, London SE1 1UL, United 
      Kingdom.
FAU - Gould, Hannah J
AU  - Gould HJ
AD  - Randall Division of Cell and Molecular Biophysics, Division of Asthma, Allergy, 
      and Lung Biology, MRC and Asthma UK Centre for Allergic Mechanisms of Asthma, 
      King's College London, New Hunt's House, Guy's Campus, London SE1 1UL, United 
      Kingdom.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Microbiol Spectr
JT  - Microbiology spectrum
JID - 101634614
EDAT- 2013/10/01 00:00
MHDA- 2013/10/01 00:01
CRDT- 2015/07/18 06:00
PHST- 2015/07/18 06:00 [entrez]
PHST- 2013/10/01 00:00 [pubmed]
PHST- 2013/10/01 00:01 [medline]
AID - 10.1128/microbiolspec.AID-0006-2012 [doi]
PST - ppublish
SO  - Microbiol Spectr. 2013 Oct;1(1). doi: 10.1128/microbiolspec.AID-0006-2012.