PMID- 26186651
OWN - NLM
STAT- MEDLINE
DCOM- 20160510
LR  - 20181113
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 10
IP  - 7
DP  - 2015
TI  - Correlation between Systemic Oxidative Stress and Intraocular Pressure Level.
PG  - e0133582
LID - 10.1371/journal.pone.0133582 [doi]
LID - e0133582
AB  - BACKGROUND: The involvement of local and systemic oxidative stress in intraocular 
      pressure (IOP) elevation and optic nerve damage has been hypothesized in the 
      pathogenesis of glaucoma. We reported previously that the level of systemic 
      antioxidative capacity is lower in patients with open-angle glaucoma than 
      controls without glaucoma. Here, we assessed the correlation between IOP and 
      systemic levels of prooxidants and antioxidants by analyzing the blood 
      biochemistry in patients with glaucoma. METHODS: Peripheral blood samples were 
      collected from Japanese patients with primary open-angle glaucoma (n = 206), 
      exfoliation syndrome (n = 199), and controls (n = 126). Serum levels of lipid 
      peroxides, ferric-reducing activity, and thiol antioxidant activity were measured 
      by diacron reactive oxygen metabolite (dROM), biological antioxidant potential 
      (BAP), and sulfhydryl (SH) tests, respectively, using a free radical analyzer. To 
      test the possible effect of oxidative stress on IOP levels, the patients were 
      classified into one of four groups (Q1, Q2, Q3, and Q4, with Q1 having the lowest 
      IOP) based on the quartile value of IOP. For this classification, the known 
      highest IOP value in both the right and left eyes was regarded as each subject's 
      IOP. For comparisons among the IOP groups, the differences were calculated using 
      one-way analysis of variance followed by post-hoc unpaired t-tests. To adjust for 
      differences in demographic characteristic distributions, the dROM, BAP, and SH 
      test values were compared among the IOP groups using multiple logistic regression 
      analysis; the odds ratio (OR) of each variable was calculated with the Q1 group 
      as the reference. RESULTS: The dROM and the SH levels did not differ 
      significantly (p = 0.6704 and p = 0.6376, respectively) among the four IOP 
      groups. The BAP levels differed significantly (p = 0.0115) among the four IOP 
      groups; the value was significantly lower in the Q4 group (1,932 mumol/L) compared 
      with the Q1 (2,023 mumol/L, p = 0.0042) and Q2 (2,003 mumol/L, p = 0.0302) groups 
      and significantly lower in the Q3 group (1,948 mumol/L) than the Q1 (p = 0.0174) 
      group. After adjustment for differences in various demographic characteristics, 
      lower BAP values were significantly associated with the classification into 
      higher IOP groups (Q3 group, p = 0.0261 and OR = 0.06/range; Q4 group, p = 0.0018 
      and OR = 0.04/range). The dROM and SH values did not reach significance in any 
      comparisons. CONCLUSIONS: Lower systemic antioxidant capacity measured by 
      ferric-reducing activity is involved in the pathogenesis of open-angle glaucoma 
      via its roles in IOP elevation.
FAU - Tanito, Masaki
AU  - Tanito M
AD  - Division of Ophthalmology, Matsue Red Cross Hospital, Matsue, Shimane, Japan; 
      Department of Ophthalmology, Shimane University Faculty of Medicine, Izumo, 
      Shimane, Japan.
FAU - Kaidzu, Sachiko
AU  - Kaidzu S
AD  - Department of Ophthalmology, Shimane University Faculty of Medicine, Izumo, 
      Shimane, Japan.
FAU - Takai, Yasuyuki
AU  - Takai Y
AD  - Department of Ophthalmology, Shimane University Faculty of Medicine, Izumo, 
      Shimane, Japan.
FAU - Ohira, Akihiro
AU  - Ohira A
AD  - Department of Ophthalmology, Shimane University Faculty of Medicine, Izumo, 
      Shimane, Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150717
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Free Radicals)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Case-Control Studies
MH  - Exfoliation Syndrome/*blood/physiopathology
MH  - Female
MH  - Free Radicals/blood
MH  - Glaucoma, Open-Angle/*blood/physiopathology
MH  - Humans
MH  - *Intraocular Pressure
MH  - Male
MH  - Middle Aged
MH  - *Oxidative Stress
PMC - PMC4506090
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2015/07/18 06:00
MHDA- 2016/05/11 06:00
PMCR- 2015/07/17
CRDT- 2015/07/18 06:00
PHST- 2015/03/22 00:00 [received]
PHST- 2015/06/29 00:00 [accepted]
PHST- 2015/07/18 06:00 [entrez]
PHST- 2015/07/18 06:00 [pubmed]
PHST- 2016/05/11 06:00 [medline]
PHST- 2015/07/17 00:00 [pmc-release]
AID - PONE-D-15-12327 [pii]
AID - 10.1371/journal.pone.0133582 [doi]
PST - epublish
SO  - PLoS One. 2015 Jul 17;10(7):e0133582. doi: 10.1371/journal.pone.0133582. 
      eCollection 2015.