PMID- 26187330
OWN - NLM
STAT- MEDLINE
DCOM- 20160606
LR  - 20150810
IS  - 1096-0023 (Electronic)
IS  - 1043-4666 (Linking)
VI  - 75
IP  - 1
DP  - 2015 Sep
TI  - Tumor necrosis factor-alpha and interleukin-1beta gene polymorphisms and risk of brain 
      abscess in North Indian population.
PG  - 159-64
LID - S1043-4666(15)30019-3 [pii]
LID - 10.1016/j.cyto.2015.07.009 [doi]
AB  - OBJECTIVE: Brain abscess develops in response to a parenchymal infection with 
      pyogenic bacteria. Tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) are 
      the most crucial pro-inflammatory cytokines with both beneficial and destructive 
      properties for the central nervous system. The present study evaluated the 
      association of specific alleles/genotypes of TNF-alpha and IL-1beta with brain abscess. 
      MATERIAL AND METHODS: A total of 90 brain abscess patients and 100 healthy 
      controls were included in the study. Predisposing factors were identified in 56 
      (62.2%) patients with brain abscess. TNF-alpha (-308 G>A) and IL-1beta (-511 C<T) 
      genotypes were detected by PCR-RFLP. Levels of TNF-alpha and IL-1beta were determined in 
      patients' sera and in pus samples by ELISA and correlated with different 
      genotypes. RESULTS: TNF-alpha genotypes AA and GA (p<0.001 for AA and p=0.001 for 
      GA), and IL-1beta genotypes C/C and C/T (p<0.001 for C/C and p=0.049 for C/T) were 
      significantly associated with brain abscess. Homozygous AA genotype of TNF-alpha had 
      significant association with brain abscess patients having identified 
      predisposing factors (p=0.026). Patients with heterozygous or homozygous A allele 
      in TNF-alpha (-308 G>A) and C allele in IL-1beta (-511 C<T) had significantly higher 
      levels of TNF-alpha and IL-1beta. CONCLUSION: TNF-alpha (-308 G>A) and IL-1beta (-511 C<T) 
      polymorphisms that lead to increased production of TNF-alpha and IL-1beta appear to be 
      risk for development of brain abscess in North Indian population.
CI  - Copyright (c) 2015 Elsevier Ltd. All rights reserved.
FAU - Mishra, Priyanka
AU  - Mishra P
AD  - Department of Microbiology, Sanjay Gandhi Postgraduate Institute of Medical 
      Sciences, Lucknow, India.
FAU - Prasad, Kashi Nath
AU  - Prasad KN
AD  - Department of Microbiology, Sanjay Gandhi Postgraduate Institute of Medical 
      Sciences, Lucknow, India. Electronic address: kashinprasad@gmail.com.
FAU - Singh, Kamini
AU  - Singh K
AD  - Department of Microbiology, Sanjay Gandhi Postgraduate Institute of Medical 
      Sciences, Lucknow, India.
FAU - Bajpai, Anamika
AU  - Bajpai A
AD  - Department of Microbiology, Sanjay Gandhi Postgraduate Institute of Medical 
      Sciences, Lucknow, India.
FAU - Sahu, Rabi Narayan
AU  - Sahu RN
AD  - Department of Neurosurgery, Sanjay Gandhi Postgraduate Institute of Medical 
      Sciences, Lucknow, India.
FAU - Ojha, Bal Krishna
AU  - Ojha BK
AD  - Department of Neurosurgery, King George Medical University, Lucknow, India.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150714
PL  - England
TA  - Cytokine
JT  - Cytokine
JID - 9005353
RN  - 0 (Cytokines)
RN  - 0 (IL1B protein, human)
RN  - 0 (Interleukin-1beta)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Alleles
MH  - Brain/metabolism
MH  - Brain Abscess/*ethnology/*genetics
MH  - Case-Control Studies
MH  - Child
MH  - Cytokines/genetics
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Heterozygote
MH  - Homozygote
MH  - Humans
MH  - India
MH  - Interleukin-1beta/*genetics
MH  - Male
MH  - Middle Aged
MH  - Polymerase Chain Reaction
MH  - *Polymorphism, Genetic
MH  - Polymorphism, Restriction Fragment Length
MH  - Risk Factors
MH  - Tumor Necrosis Factor-alpha/*genetics
MH  - Young Adult
OTO - NOTNLM
OT  - Brain abscess
OT  - IL-1beta
OT  - Polymorphisms
OT  - Serum level
OT  - TNF-alpha
EDAT- 2015/07/19 06:00
MHDA- 2016/06/09 06:00
CRDT- 2015/07/19 06:00
PHST- 2014/12/17 00:00 [received]
PHST- 2015/07/07 00:00 [revised]
PHST- 2015/07/08 00:00 [accepted]
PHST- 2015/07/19 06:00 [entrez]
PHST- 2015/07/19 06:00 [pubmed]
PHST- 2016/06/09 06:00 [medline]
AID - S1043-4666(15)30019-3 [pii]
AID - 10.1016/j.cyto.2015.07.009 [doi]
PST - ppublish
SO  - Cytokine. 2015 Sep;75(1):159-64. doi: 10.1016/j.cyto.2015.07.009. Epub 2015 Jul 
      14.