PMID- 26188621
OWN - NLM
STAT- MEDLINE
DCOM- 20160524
LR  - 20150818
IS  - 1768-3254 (Electronic)
IS  - 0223-5234 (Linking)
VI  - 101
DP  - 2015 Aug 28
TI  - Chalcone scaffolds as anti-infective agents: structural and molecular target 
      perspectives.
PG  - 496-524
LID - S0223-5234(15)30131-8 [pii]
LID - 10.1016/j.ejmech.2015.06.052 [doi]
AB  - In recent years, widespread outbreak of numerous infectious diseases across the 
      globe has created havoc among the population. Particularly, the inhabitants of 
      tropical and sub-tropical regions are mainly affected by these pathogens. Several 
      natural and (semi) synthetic chalcones deserve the credit of being potential 
      anti-infective candidates that inhibit various parasitic, malarial, bacterial, 
      viral, and fungal targets like cruzain-1/2, trypanopain-Tb, trans-sialidase, 
      glyceraldehyde-3-phosphate dehydrogenase (GAPDH), fumarate reductase, 
      falcipain-1/2, beta-hematin, topoisomerase-II, plasmepsin-II, lactate dehydrogenase, 
      protein kinases (Pfmrk and PfPK5), and sorbitol-induced hemolysis, DEN-1 NS3, 
      H1N1, HIV (Integrase/Protease), protein tyrosine phosphatase A/B (Ptp-A/B), FtsZ, 
      FAS-II, lactate/isocitrate dehydrogenase, NorA efflux pump, DNA gyrase, fatty 
      acid synthase, chitin synthase, and beta-(1,3)-glucan synthase. In this review, a 
      comprehensive study (from Jan. 1982 to May 2015) of the structural features of 
      anti-infective chalcones, their mechanism of actions (MOAs) and structure 
      activity relationships (SARs) have been highlighted. With the knowledge of 
      molecular targets, structural insights and SARs, this review may be helpful for 
      (medicinal) chemists to design more potent, safe, selective and cost effective 
      anti-infective agents.
CI  - Copyright (c) 2015 Elsevier Masson SAS. All rights reserved.
FAU - Mahapatra, Debarshi Kar
AU  - Mahapatra DK
AD  - Institute of Pharmaceutical Sciences, Guru Ghasidas Vishwavidyalaya (A Central 
      University), Bilaspur 495009, Chhattisgarh, India.
FAU - Bharti, Sanjay Kumar
AU  - Bharti SK
AD  - Institute of Pharmaceutical Sciences, Guru Ghasidas Vishwavidyalaya (A Central 
      University), Bilaspur 495009, Chhattisgarh, India. Electronic address: 
      skbharti.ggu@gmail.com.
FAU - Asati, Vivek
AU  - Asati V
AD  - Institute of Pharmaceutical Sciences, Guru Ghasidas Vishwavidyalaya (A Central 
      University), Bilaspur 495009, Chhattisgarh, India.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20150710
PL  - France
TA  - Eur J Med Chem
JT  - European journal of medicinal chemistry
JID - 0420510
RN  - 0 (Anti-Infective Agents)
RN  - 0 (Enzymes)
RN  - 5S5A2Q39HX (Chalcone)
SB  - IM
MH  - Animals
MH  - Anti-Infective Agents/chemical synthesis/*chemistry/*pharmacology
MH  - Chalcone/chemical synthesis/*chemistry/*pharmacology
MH  - *Drug Design
MH  - Enzymes/*metabolism
MH  - Humans
MH  - Molecular Structure
MH  - Structure-Activity Relationship
OTO - NOTNLM
OT  - Anti-malarial
OT  - Anti-parasitic
OT  - Chalcone
OT  - Mechanism of actions
OT  - Molecular targets
OT  - Structure activity relationships
EDAT- 2015/07/21 06:00
MHDA- 2016/05/25 06:00
CRDT- 2015/07/20 06:00
PHST- 2015/03/17 00:00 [received]
PHST- 2015/05/27 00:00 [revised]
PHST- 2015/06/28 00:00 [accepted]
PHST- 2015/07/20 06:00 [entrez]
PHST- 2015/07/21 06:00 [pubmed]
PHST- 2016/05/25 06:00 [medline]
AID - S0223-5234(15)30131-8 [pii]
AID - 10.1016/j.ejmech.2015.06.052 [doi]
PST - ppublish
SO  - Eur J Med Chem. 2015 Aug 28;101:496-524. doi: 10.1016/j.ejmech.2015.06.052. Epub 
      2015 Jul 10.