PMID- 26189033 OWN - NLM STAT- MEDLINE DCOM- 20161014 LR - 20191210 IS - 1433-8491 (Electronic) IS - 0940-1334 (Linking) VI - 266 IP - 1 DP - 2016 Feb TI - Faux pas recognition performance in a help-seeking population at clinical high risk of psychosis. PG - 71-8 LID - 10.1007/s00406-015-0615-z [doi] AB - There is a growing body of evidence suggesting that patients with psychosis show impaired theory of mind (ToM). However, much remains to be understood as to whether ToM deficits occur in the premorbid or post-onset period of psychosis. Our primary aim was to examine empirically impairment on ToM tasks in a group of individuals with clinical high risk (CHR) of psychosis. Fifty CHR participants identified through the Structured Interview for Prodromal Syndromes and 52 age-/education-matched controls were assessed with a complete standard neuropsychological battery (the MCCB, MATRICS Consensus Cognitive Battery) and a social cognition assessment (Faux Pas Test, FPT). We then examined the association of baseline FPT performance with conversion to psychosis at 12-month follow-up. Compared with controls, the CHR group showed significantly poorer performances on the FPT and most MCCB domains. Significant positive correlations were found between faux pas detection and the MCCB domains of Attention/Vigilance and Working Memory in CHR participants when controlling for age and years of education. Mean scores on the FPT in 14 converters who were diagnosed with full-blown psychosis within 12 months were significantly lower than they were for non-converters. Impairments in ToM ability are acquired earlier in the prodromal stage of psychosis, along with general cognition (such as memory function) deficits. Declines in ToM ability may overlap with the progress of psychosis (the gradual loss insight), sharing similar neural substrates, and reflected by impairments in basic cognitive function. FAU - Zhang, TianHong AU - Zhang T AD - Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai Key Laboratory of Psychotic Disorders, 600 South Wanping Road, Shanghai, 200030, People's Republic of China. FAU - Yi, ZhengHui AU - Yi Z AD - Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai Key Laboratory of Psychotic Disorders, 600 South Wanping Road, Shanghai, 200030, People's Republic of China. FAU - Li, HuiJun AU - Li H AD - Department of Psychology, Florida A&M University, Tallahassee, FL, 32307, USA. AD - Department of Psychiatry, Beth Israel Deaconess Medical Center, Harvard Medical School, 75 Fenwood Rd, Boston, MA, 02115, USA. FAU - Cui, HuiRu AU - Cui H AD - Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai Key Laboratory of Psychotic Disorders, 600 South Wanping Road, Shanghai, 200030, People's Republic of China. FAU - Tang, YingYing AU - Tang Y AD - Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai Key Laboratory of Psychotic Disorders, 600 South Wanping Road, Shanghai, 200030, People's Republic of China. FAU - Lu, Xi AU - Lu X AD - Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai Key Laboratory of Psychotic Disorders, 600 South Wanping Road, Shanghai, 200030, People's Republic of China. FAU - Xu, LiHua AU - Xu L AD - Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai Key Laboratory of Psychotic Disorders, 600 South Wanping Road, Shanghai, 200030, People's Republic of China. FAU - Qian, ZhenYing AU - Qian Z AD - Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai Key Laboratory of Psychotic Disorders, 600 South Wanping Road, Shanghai, 200030, People's Republic of China. FAU - Zhu, YiKang AU - Zhu Y AD - Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai Key Laboratory of Psychotic Disorders, 600 South Wanping Road, Shanghai, 200030, People's Republic of China. FAU - Jiang, LiJuan AU - Jiang L AD - Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai Key Laboratory of Psychotic Disorders, 600 South Wanping Road, Shanghai, 200030, People's Republic of China. FAU - Chow, Annabelle AU - Chow A AD - Department of Psychological Medicine, Changi General Hospital, Singapore, Singapore. FAU - Li, ChunBo AU - Li C AD - Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai Key Laboratory of Psychotic Disorders, 600 South Wanping Road, Shanghai, 200030, People's Republic of China. FAU - Jiang, KaiDa AU - Jiang K AD - Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai Key Laboratory of Psychotic Disorders, 600 South Wanping Road, Shanghai, 200030, People's Republic of China. FAU - Xiao, ZePing AU - Xiao Z AD - Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai Key Laboratory of Psychotic Disorders, 600 South Wanping Road, Shanghai, 200030, People's Republic of China. xiaozeping88@163.com. FAU - Wang, JiJun AU - Wang J AD - Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai Key Laboratory of Psychotic Disorders, 600 South Wanping Road, Shanghai, 200030, People's Republic of China. jijunwang27@163.com. LA - eng GR - 1R21 MH093294-01A1/MH/NIMH NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't DEP - 20150719 PL - Germany TA - Eur Arch Psychiatry Clin Neurosci JT - European archives of psychiatry and clinical neuroscience JID - 9103030 SB - IM MH - Adolescent MH - Adult MH - Cognition Disorders/diagnosis/*etiology MH - Female MH - *Help-Seeking Behavior MH - Humans MH - Male MH - Neuropsychological Tests MH - Psychiatric Status Rating Scales MH - *Psychotic Disorders/complications/diagnosis/psychology MH - Recognition, Psychology/*physiology MH - Risk Factors MH - Statistics, Nonparametric MH - Surveys and Questionnaires MH - *Theory of Mind MH - Young Adult OTO - NOTNLM OT - Conversion OT - Prodromal psychosis OT - Social cognition OT - Ultra high risk OT - Working memory EDAT- 2015/07/21 06:00 MHDA- 2016/10/16 06:00 CRDT- 2015/07/20 06:00 PHST- 2015/02/27 00:00 [received] PHST- 2015/07/03 00:00 [accepted] PHST- 2015/07/20 06:00 [entrez] PHST- 2015/07/21 06:00 [pubmed] PHST- 2016/10/16 06:00 [medline] AID - 10.1007/s00406-015-0615-z [pii] AID - 10.1007/s00406-015-0615-z [doi] PST - ppublish SO - Eur Arch Psychiatry Clin Neurosci. 2016 Feb;266(1):71-8. doi: 10.1007/s00406-015-0615-z. Epub 2015 Jul 19.