PMID- 26189092
OWN - NLM
STAT- MEDLINE
DCOM- 20160519
LR  - 20150908
IS  - 1558-1497 (Electronic)
IS  - 0197-4580 (Linking)
VI  - 36
IP  - 10
DP  - 2015 Oct
TI  - Inhibition of Tnf-alpha R1 signaling can rescue functional cortical plasticity 
      impaired in early post-stroke period.
PG  - 2877-84
LID - S0197-4580(15)00326-7 [pii]
LID - 10.1016/j.neurobiolaging.2015.06.015 [doi]
AB  - Tumor necrosis factor-alpha (TNF-alpha) is one of the key players in stroke progression 
      and can interfere with brain functioning. We previously documented an impairment 
      of experience-dependent plasticity in the cortex neighboring the stroke-induced 
      lesion, which was accompanied with an upregulation of Tnf-alpha level in the brain of 
      ischemic mice 1 week after the stroke. Because TNF receptor 1 (TnfR1) signaling 
      is believed to be a major mediator of the cytotoxicity of Tnf-alpha through 
      activation of caspases, we used an anti-inflammatory intervention aimed at Tnf-alpha 
      R1 pathway, in order to try to attenuate the detrimental effect of post-stroke 
      inflammation, and investigated if this will be effective in protecting plasticity 
      in the infarct proximity. Aged mice (12-14 months) were subjected to the 
      photothrombotic stroke localized near somatosensory cortex, and immediately after 
      ischemia sensory deprivation was introduced to induce plasticity. Soluble TNF-alpha 
      R1 (sTNF-alpha R1), which competed for TNF-alpha with receptors localized in the brain, 
      was delivered chronically directly into the brain tissue for the whole period of 
      deprivation using ALZET Micro-Osmotic pumps. We have shown that such approach 
      undertaken simultaneously with the stroke reduced the level of TNF-alpha in the 
      peri-ischemic tissue and was successful in preserving the post-stroke 
      deprivation-induced brain plasticity.
CI  - Copyright (c) 2015 Elsevier Inc. All rights reserved.
FAU - Liguz-Lecznar, Monika
AU  - Liguz-Lecznar M
AD  - Department of Molecular and Cellular Neurobiology, Laboratory of Neuroplasticity, 
      Nencki Institute of Experimental Biology, Warsaw, Poland. Electronic address: 
      m.liguz@nencki.gov.pl.
FAU - Zakrzewska, Renata
AU  - Zakrzewska R
AD  - Department of Molecular and Cellular Neurobiology, Laboratory of Neuroplasticity, 
      Nencki Institute of Experimental Biology, Warsaw, Poland.
FAU - Kossut, Malgorzata
AU  - Kossut M
AD  - Department of Molecular and Cellular Neurobiology, Laboratory of Neuroplasticity, 
      Nencki Institute of Experimental Biology, Warsaw, Poland; University of Social 
      Science and Humanities, Warsaw, Poland.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150618
PL  - United States
TA  - Neurobiol Aging
JT  - Neurobiology of aging
JID - 8100437
RN  - 0 (Receptors, Tumor Necrosis Factor, Type I)
RN  - 0 (Tnfrsf1a protein, mouse)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Animals
MH  - Binding, Competitive
MH  - Brain/metabolism/physiopathology
MH  - Female
MH  - Infusion Pumps
MH  - Mice, Inbred C57BL
MH  - Molecular Targeted Therapy
MH  - Neuronal Plasticity/*genetics
MH  - Receptors, Tumor Necrosis Factor, Type I/*administration & 
      dosage/metabolism/*physiology
MH  - Signal Transduction/*drug effects/genetics/*physiology
MH  - Somatosensory Cortex/*physiopathology
MH  - Stroke/*genetics/metabolism/physiopathology/*therapy
MH  - Time Factors
MH  - Tumor Necrosis Factor-alpha/metabolism
OTO - NOTNLM
OT  - Brain
OT  - Inflammation
OT  - Photothrombotic stroke
OT  - Plasticity
OT  - Tnf-alpha
OT  - sTNFalpha R1
EDAT- 2015/07/21 06:00
MHDA- 2016/05/20 06:00
CRDT- 2015/07/20 06:00
PHST- 2015/02/27 00:00 [received]
PHST- 2015/06/08 00:00 [revised]
PHST- 2015/06/10 00:00 [accepted]
PHST- 2015/07/20 06:00 [entrez]
PHST- 2015/07/21 06:00 [pubmed]
PHST- 2016/05/20 06:00 [medline]
AID - S0197-4580(15)00326-7 [pii]
AID - 10.1016/j.neurobiolaging.2015.06.015 [doi]
PST - ppublish
SO  - Neurobiol Aging. 2015 Oct;36(10):2877-84. doi: 
      10.1016/j.neurobiolaging.2015.06.015. Epub 2015 Jun 18.