PMID- 26189407
OWN - NLM
STAT- MEDLINE
DCOM- 20160720
LR  - 20151002
IS  - 1399-5448 (Electronic)
IS  - 1399-543X (Linking)
VI  - 16
IP  - 7
DP  - 2015 Nov
TI  - Association between IgE-mediated allergies and diabetes mellitus type 1 in 
      children and adolescents.
PG  - 493-503
LID - 10.1111/pedi.12298 [doi]
AB  - BACKGROUND: Type 1 diabetes mellitus (T1DM) is characterized by an immunological 
      reaction that is dominated by type-1 T helper (Th1) cells, whereas immunoglobulin 
      E (IgE)-mediated allergies are associated with Th2 cell. According to the 
      Th1/Th2-hypothesis, the immune system is said to either develop into the 
      direction of Th1 or Th2 cells. This would mean that a child developing T1DM is 
      unlikely to develop an IgE-mediated allergy and vice versa. OBJECTIVE: The aim of 
      the study was to investigate the association between the prevalence of T1DM and 
      IgE-mediated allergies. METHODS: We designed a prospective case control study 
      with 94 children and adolescents with T1DM and 188 age- and sex-matched control 
      children. The basis of our investigations was a questionnaire concerning the 
      family and children's history as to the presence of IgE-mediated allergies. 
      Moreover, the following blood investigations were done: total serum IgE, specific 
      IgE antibodies to major inhalant allergens, and a multiplex cytokine analysis 
      measuring levels of specific cytokines representing either Th1- or Th2- 
      cytokines. RESULTS: Children with T1DM reported the presence of IgE-mediated 
      allergies significantly more often than children of the control group. Children 
      with T1DM had significantly higher tumor necrosis factor alpha (TNFalpha) levels than 
      healthy controls. Levels of interleukin-2 (IL-2) and IL-6 were higher in the 
      groups of children with the presence of a personal history of allergies, 
      regardless of the presence of T1DM. CONCLUSIONS: Our results suggest that T1DM is 
      associated with a higher risk of a self-reported presence of IgE-mediated 
      allergies and that the Th1/Th2-hypothesis may be an oversimplification.
CI  - (c) 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Klamt, Sabine
AU  - Klamt S
AD  - LIFE - Leipzig Research Center for Civilization Diseases, University of Leipzig, 
      Leipzig, Germany.
AD  - Hospital for Children and Adolescents, University of Leipzig, Leipzig, Germany.
AD  - Centre for Paediatric Research (CPL), University of Leipzig, Leipzig, Germany.
FAU - Vogel, Mandy
AU  - Vogel M
AD  - LIFE - Leipzig Research Center for Civilization Diseases, University of Leipzig, 
      Leipzig, Germany.
AD  - Centre for Paediatric Research (CPL), University of Leipzig, Leipzig, Germany.
FAU - Kapellen, Thomas M
AU  - Kapellen TM
AD  - Hospital for Children and Adolescents, University of Leipzig, Leipzig, Germany.
AD  - Centre for Paediatric Research (CPL), University of Leipzig, Leipzig, Germany.
FAU - Hiemisch, Andreas
AU  - Hiemisch A
AD  - LIFE - Leipzig Research Center for Civilization Diseases, University of Leipzig, 
      Leipzig, Germany.
AD  - Hospital for Children and Adolescents, University of Leipzig, Leipzig, Germany.
AD  - Centre for Paediatric Research (CPL), University of Leipzig, Leipzig, Germany.
FAU - Prenzel, Freerk
AU  - Prenzel F
AD  - Hospital for Children and Adolescents, University of Leipzig, Leipzig, Germany.
AD  - Centre for Paediatric Research (CPL), University of Leipzig, Leipzig, Germany.
FAU - Zachariae, Silke
AU  - Zachariae S
AD  - LIFE - Leipzig Research Center for Civilization Diseases, University of Leipzig, 
      Leipzig, Germany.
AD  - Institute for Medical Informatics, Statistics and Epidemiology (IMISE), 
      University of Leipzig, Leipzig, Germany.
FAU - Ceglarek, Uta
AU  - Ceglarek U
AD  - LIFE - Leipzig Research Center for Civilization Diseases, University of Leipzig, 
      Leipzig, Germany.
AD  - Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, 
      University of Leipzig, Leipzig, Germany.
FAU - Thiery, Joachim
AU  - Thiery J
AD  - LIFE - Leipzig Research Center for Civilization Diseases, University of Leipzig, 
      Leipzig, Germany.
AD  - Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, 
      University of Leipzig, Leipzig, Germany.
FAU - Kiess, Wieland
AU  - Kiess W
AD  - LIFE - Leipzig Research Center for Civilization Diseases, University of Leipzig, 
      Leipzig, Germany.
AD  - Hospital for Children and Adolescents, University of Leipzig, Leipzig, Germany.
AD  - Centre for Paediatric Research (CPL), University of Leipzig, Leipzig, Germany.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150717
PL  - Denmark
TA  - Pediatr Diabetes
JT  - Pediatric diabetes
JID - 100939345
RN  - 0 (Cytokines)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Case-Control Studies
MH  - Child
MH  - Child, Preschool
MH  - Cytokines/blood
MH  - Diabetes Mellitus, Type 1/blood/complications/epidemiology/*immunology
MH  - Family Health
MH  - Female
MH  - Germany/epidemiology
MH  - Hospitals, Pediatric
MH  - Hospitals, University
MH  - Humans
MH  - Hypersensitivity, Immediate/blood/complications/epidemiology/*immunology
MH  - Immunoglobulin E/*analysis
MH  - Male
MH  - Prevalence
MH  - Prospective Studies
MH  - *Th1-Th2 Balance
MH  - Young Adult
OTO - NOTNLM
OT  - allergy
OT  - asthma
OT  - children
OT  - diabetes
OT  - immunoglobulin E
EDAT- 2015/07/21 06:00
MHDA- 2016/07/21 06:00
CRDT- 2015/07/21 06:00
PHST- 2015/05/01 00:00 [received]
PHST- 2015/06/10 00:00 [revised]
PHST- 2015/06/22 00:00 [accepted]
PHST- 2015/07/21 06:00 [entrez]
PHST- 2015/07/21 06:00 [pubmed]
PHST- 2016/07/21 06:00 [medline]
AID - 10.1111/pedi.12298 [doi]
PST - ppublish
SO  - Pediatr Diabetes. 2015 Nov;16(7):493-503. doi: 10.1111/pedi.12298. Epub 2015 Jul 
      17.