PMID- 2618961
OWN - NLM
STAT- MEDLINE
DCOM- 19900301
LR  - 20190908
IS  - 0387-7604 (Print)
IS  - 0387-7604 (Linking)
VI  - 11
IP  - 6
DP  - 1989
TI  - Incidence and causes of intracranial hemorrhage in infancy: a prospective 
      surveillance study after vitamin K prophylaxis.
PG  - 384-8
AB  - In order to evaluate the effect of vitamin K prophylaxis on the incidence of 
      intracranial hemorrhage (ICH) in infants aged from 1 week to 12 months, a 
      prospective surveillance study, from 1974 to 1988, was performed on the 
      well-defined population of Nagasaki Prefecture, Japan. The incidence of ICH in 
      infancy markedly decreased, from 34.3/100,000 to 10.1/100,000 live births, with 
      the oral administration of vitamin K2 at both birth and 1 week, or with 
      additional supplementation at 1 month of age. The diminished incidence was 
      attributed to the decreased occurrence of acute ICH due to late hemorrhagic 
      disease (LHD), a late onset form of vitamin K deficiency, and chronic subdural 
      hematoma. On comparing the possible etiological factors, and clinical and 
      laboratory findings between these 2 groups, it became apparent that chronic 
      subdural hematoma shared some etiological factors (such as breast-feeding, liver 
      dysfunction and no supplementation of vitamin K) with LHD. Furthermore, chronic 
      subdural hematoma developed in some patients who had previously had acute ICH due 
      to LHD. These findings suggest that coagulopathy due to vitamin K deficiency, 
      including LHD, is causally related in the majority of, if not all, cases of 
      chronic subdural hematoma without any history of trauma or central nervous system 
      infections.
FAU - Matsuzaka, T
AU  - Matsuzaka T
AD  - Department of Pediatrics, Nagasaki University School of Medicine, Japan.
FAU - Yoshinaga, M
AU  - Yoshinaga M
FAU - Tsuji, Y
AU  - Tsuji Y
FAU - Yasunaga, A
AU  - Yasunaga A
FAU - Mori, K
AU  - Mori K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Brain Dev
JT  - Brain & development
JID - 7909235
RN  - 12001-79-5 (Vitamin K)
SB  - IM
MH  - Cerebral Hemorrhage/etiology/*prevention & control
MH  - Female
MH  - Follow-Up Studies
MH  - Hematoma, Subdural/etiology/*prevention & control
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Male
MH  - Vitamin K/*therapeutic use
EDAT- 1989/01/01 00:00
MHDA- 1989/01/01 00:01
CRDT- 1989/01/01 00:00
PHST- 1989/01/01 00:00 [pubmed]
PHST- 1989/01/01 00:01 [medline]
PHST- 1989/01/01 00:00 [entrez]
AID - S0387-7604(89)80021-X [pii]
AID - 10.1016/s0387-7604(89)80021-x [doi]
PST - ppublish
SO  - Brain Dev. 1989;11(6):384-8. doi: 10.1016/s0387-7604(89)80021-x.