PMID- 26191251
OWN - NLM
STAT- MEDLINE
DCOM- 20160524
LR  - 20181113
IS  - 1936-2625 (Electronic)
IS  - 1936-2625 (Linking)
VI  - 8
IP  - 5
DP  - 2015
TI  - Pachymic acid modified carbon nanoparticles reduced angiogenesis via inhibition 
      of MMP-3.
PG  - 5464-70
AB  - Angiogenesis is a process of new blood vessel generation, which is consistently 
      and robustly correlated with tumor formation, growth, and metastasis. The 
      disruption of angiogenesis, and the imbalanced endothelial remodeling and 
      regression, are the main pathogenesis of malignant tumor. Recently, multi-walled 
      nanotubes (MWNTs) have been proposed as a new tool for drug delivery in cancer 
      treatment, which also displayed anti-angiogenic property. In the present study, 
      we modified MWNTs with pachymic acid (PA) extracted from Heterosmilax chinensis, 
      a traditional Chinese medicine used for cancer treatment, and compared their 
      effects on blood vessel development. MWNTs and PA/MWNTs were evaluated for their 
      influences on chorioallantoic membrane (CAM) vessel morphology and extracellular 
      matrix metalloproteinase-3 (MMP-3) expression, a crucial proteinase associated 
      with tumor metastasis. MWNTs functioned as an inhibitor of forming branch while 
      PA was not able to promote this inhibition. Subsequently, MWNTs suppressed the 
      endothelial cell maturation, accounting for the ceased elongation of CAM blood 
      vessel, while PA/MWNTs increased the suppressive effect, indicating the potential 
      roles of PA in preventing angiogenesis. PA/MWNTs also showed greater 
      anti-angiogenic property as MMP-3 expression in CAM tissue was significantly 
      decreased by PA/MWNTs compared to MWNTs. These results emphasize the 
      anti-angiogenic activities of PA, supporting a new promising therapy for cancer 
      from the perspective of traditional Chinese medicine.
FAU - Ma, Jun
AU  - Ma J
AD  - Department of Integrative Medicine, Zhongshan Hospital, Fudan University Shanghai 
      200032, China.
FAU - Liu, Jun
AU  - Liu J
AD  - Department of Integrative Medicine, Zhongshan Hospital, Fudan University Shanghai 
      200032, China.
FAU - Lu, Chun-Wei
AU  - Lu CW
AD  - Department of Integrative Medicine, Zhongshan Hospital, Fudan University Shanghai 
      200032, China.
FAU - Cai, Ding-Fang
AU  - Cai DF
AD  - Department of Integrative Medicine, Zhongshan Hospital, Fudan University Shanghai 
      200032, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150501
PL  - United States
TA  - Int J Clin Exp Pathol
JT  - International journal of clinical and experimental pathology
JID - 101480565
RN  - 0 (Angiogenesis Inhibitors)
RN  - 0 (Matrix Metalloproteinase Inhibitors)
RN  - 0 (Triterpenes)
RN  - 7440-44-0 (Carbon)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
RN  - X2FCK16QAH (pachymic acid)
SB  - IM
MH  - Angiogenesis Inhibitors/*pharmacology
MH  - Animals
MH  - Carbon
MH  - Chickens
MH  - Chorioallantoic Membrane/drug effects/metabolism
MH  - Matrix Metalloproteinase 3/*metabolism
MH  - Matrix Metalloproteinase Inhibitors/*pharmacology
MH  - Nanoparticles
MH  - Neovascularization, Pathologic/*metabolism
MH  - Triterpenes/*pharmacology
PMC - PMC4503122
OTO - NOTNLM
OT  - Angiogenesis
OT  - metalloproteinase-3
OT  - metastasis
OT  - multi-walled nanotubes
EDAT- 2015/07/21 06:00
MHDA- 2016/05/25 06:00
PMCR- 2015/05/01
CRDT- 2015/07/21 06:00
PHST- 2015/02/02 00:00 [received]
PHST- 2015/04/18 00:00 [accepted]
PHST- 2015/07/21 06:00 [entrez]
PHST- 2015/07/21 06:00 [pubmed]
PHST- 2016/05/25 06:00 [medline]
PHST- 2015/05/01 00:00 [pmc-release]
PST - epublish
SO  - Int J Clin Exp Pathol. 2015 May 1;8(5):5464-70. eCollection 2015.