PMID- 26191257
OWN - NLM
STAT- MEDLINE
DCOM- 20160524
LR  - 20181113
IS  - 1936-2625 (Electronic)
IS  - 1936-2625 (Linking)
VI  - 8
IP  - 5
DP  - 2015
TI  - ELMO3 is a novel biomarker for diagnosis and prognosis of non-small cell lung 
      cancer.
PG  - 5503-8
AB  - BACKGROUND: To investigated the diagnostic and prognostic value of engulfment and 
      cell motility (ELMO3) in non small cell lung cancer (NSCLC). METHODS: The 
      expression of ELMO3 at mRNA levels were detected using reverse transcription 
      quantitative real-time polymerase chain reaction (qRT-PCR) in 125 NSCLC patients' 
      tissues and adjacent tissues, as well as in the serum of 125 NSCLC patients and 
      89 healthy controls. Then, receiver operating characteristic curve (ROC), 
      Kaplan-Meier and Cox regression analysis were adopted to estimate the potential 
      diagnostic and prognostic value of ELMO3, respectively. RESULTS: ELMO3 expression 
      level was significantly up-regulated in NSCLC patients' tissues and serum 
      compared with controls (P<0.001). Moreover, the expression of ELMO3 was 
      significantly associated with tumor size (P=0.020), TNM stage (P=0.017), lymph 
      node metastasis (PP=0.045) and distance metastasis (P=0.033). ROC showed the AUC 
      was 0.917, and the optimal cutoff value was 0.735, providing a sensitivity of 
      92.8% and a specificity of 84.3%. Furthermore, Kaplan-Meier analysis indicated 
      the high expression of ELMO3 could lead to a shorter overall survival time. In 
      multivariate analysis, ELMO3 expression (HR=3.378, 95% CI=1.326-8.587, P=0.011) 
      was proved to be linked with the prognosis of NSCLC and might act as an 
      independent prognostic marker. CONCLUSION: The over-expression of ELMO3 was a 
      potential diagnostic and prognostic marker for NSCLC.
FAU - Fan, Wei
AU  - Fan W
AD  - Department of Anesthesiology, Huai'an First People's Hospital, Nanjing Medical 
      University Jiangsu, China.
FAU - Yang, Haikou
AU  - Yang H
AD  - Department of Anesthesiology, Maternal & Child Health Care Hospital of Huai'an 
      Jiangsu, China.
FAU - Xue, Hong
AU  - Xue H
AD  - Department of Anesthesiology, Huai'an Hospital Affiliated of Xuzhou Medical 
      College and Huai'an Second People's Hospital Jiangsu, China.
FAU - Sun, Yong
AU  - Sun Y
AD  - Department of Burn and Plastic Surgery, Huai'an First People's Hospital, Nanjing 
      Medical University Jiangsu, China.
FAU - Zhang, Jun
AU  - Zhang J
AD  - Department of Anesthesiology, Huai'an First People's Hospital, Nanjing Medical 
      University Jiangsu, China.
LA  - eng
PT  - Journal Article
DEP - 20150501
PL  - United States
TA  - Int J Clin Exp Pathol
JT  - International journal of clinical and experimental pathology
JID - 101480565
RN  - 0 (Adaptor Proteins, Signal Transducing)
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Cytoskeletal Proteins)
RN  - 0 (ELMO3 protein, human)
SB  - IM
MH  - Adaptor Proteins, Signal Transducing/blood/*metabolism
MH  - Biomarkers, Tumor/metabolism
MH  - Carcinoma, Non-Small-Cell Lung/blood/*diagnosis/metabolism/pathology
MH  - Cytoskeletal Proteins/blood/*metabolism
MH  - Female
MH  - Humans
MH  - Lung/*metabolism/pathology
MH  - Lung Neoplasms/blood/*diagnosis/metabolism/pathology
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Up-Regulation
PMC - PMC4503128
OTO - NOTNLM
OT  - ELMO3
OT  - Non small cell lung cancer
OT  - diagnosis
OT  - prognosis
EDAT- 2015/07/21 06:00
MHDA- 2016/05/25 06:00
PMCR- 2015/05/01
CRDT- 2015/07/21 06:00
PHST- 2015/03/10 00:00 [received]
PHST- 2015/04/24 00:00 [accepted]
PHST- 2015/07/21 06:00 [entrez]
PHST- 2015/07/21 06:00 [pubmed]
PHST- 2016/05/25 06:00 [medline]
PHST- 2015/05/01 00:00 [pmc-release]
PST - epublish
SO  - Int J Clin Exp Pathol. 2015 May 1;8(5):5503-8. eCollection 2015.