PMID- 26191259
OWN - NLM
STAT- MEDLINE
DCOM- 20160524
LR  - 20231213
IS  - 1936-2625 (Electronic)
IS  - 1936-2625 (Linking)
VI  - 8
IP  - 5
DP  - 2015
TI  - LAMP3 and TP53 overexpression predicts poor outcome in laryngeal squamous cell 
      carcinoma.
PG  - 5519-27
AB  - Lysosomal associated membrane protein 3 (LAMP3) is a newly identified 
      tumor-specific and hypoxia-induced protein. It is a downstream target gene of 
      tumor suppressor TP53 and its expression has been associated with hypoxia-induced 
      metastasis and poor overall survival in cervical, breast and gastrointestinal 
      cancers. However, little is known of LAMP3 protein expression in laryngeal 
      squamous cell carcinoma (LSCC) and its prognostic value. We determined protein 
      expression of LAMP3 and TP53 in LSCC tissues (n=117) by immunohistochemistry 
      analysis on tissue microarray (TMA), their expression was correlated with 
      patients' clinical parameters and overall survival. LAMP3 and TP53 protein 
      expression was significantly higher in cancerous tissues compared to adjacent 
      normal surgical margin tissues. Both high LAMP3 and high TP53 protein expression 
      was significantly associated with tumor stage and size. Significant correlation 
      between LAMP3 and TP53 expression was observed. Patients with high LAMP3 or high 
      TP53 expression had a poor overall survival. Our data suggest that both 
      epithelial LAMP3 expression and TP53 expression are independent prognostic 
      markers for LSCC.
FAU - Qiu, Xiaoxia
AU  - Qiu X
AD  - Department of Otorhinolaryngology/Head and Neck Surgery, Nantong University 
      Affiliated Hospital Jiangsu 226001, China.
FAU - You, Yiwen
AU  - You Y
AD  - Department of Otorhinolaryngology/Head and Neck Surgery, Nantong University 
      Affiliated Hospital Jiangsu 226001, China.
FAU - Huang, Jianfei
AU  - Huang J
AD  - Department of Pathology, Nantong University Affiliated Hospital Jiangsu 226001, 
      China.
FAU - Wang, Xudong
AU  - Wang X
AD  - Department of Laboratory Medicine, Nantong University Affiliated Hospital Jiangsu 
      226001, China.
FAU - Zhu, Huijun
AU  - Zhu H
AD  - Department of Pathology, Nantong University Affiliated Hospital Jiangsu 226001, 
      China.
FAU - Wang, Zhiwei
AU  - Wang Z
AD  - Department of General Surgery, Nantong University Affiliated Hospital Jiangsu 
      226001, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150501
PL  - United States
TA  - Int J Clin Exp Pathol
JT  - International journal of clinical and experimental pathology
JID - 101480565
RN  - 0 (LAMP3 protein, human)
RN  - 0 (Lysosomal Membrane Proteins)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (TP53 protein, human)
RN  - 0 (Tumor Suppressor Protein p53)
SB  - IM
MH  - Carcinoma, Squamous Cell/*metabolism/mortality/pathology
MH  - Female
MH  - Humans
MH  - Laryngeal Neoplasms/*metabolism/mortality/pathology
MH  - Lysosomal Membrane Proteins/*metabolism
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Proteins/*metabolism
MH  - Prognosis
MH  - Survival Rate
MH  - Tumor Suppressor Protein p53/*metabolism
PMC - PMC4503130
OTO - NOTNLM
OT  - LAMP3
OT  - TP53
OT  - laryngeal squamous cell carcinoma
OT  - prognosis
EDAT- 2015/07/21 06:00
MHDA- 2016/05/25 06:00
PMCR- 2015/05/01
CRDT- 2015/07/21 06:00
PHST- 2015/02/11 00:00 [received]
PHST- 2015/04/12 00:00 [accepted]
PHST- 2015/07/21 06:00 [entrez]
PHST- 2015/07/21 06:00 [pubmed]
PHST- 2016/05/25 06:00 [medline]
PHST- 2015/05/01 00:00 [pmc-release]
PST - epublish
SO  - Int J Clin Exp Pathol. 2015 May 1;8(5):5519-27. eCollection 2015.