PMID- 26191285
OWN - NLM
STAT- MEDLINE
DCOM- 20160418
LR  - 20221207
IS  - 1936-2625 (Electronic)
IS  - 1936-2625 (Linking)
VI  - 8
IP  - 5
DP  - 2015
TI  - Gene polymorphism of IL-6 and MMP-3 decreases passive range of motion after 
      rotator cuff repair.
PG  - 5709-14
AB  - OBJECTIVES: Post-operative stiffness is common after rotator cuff repair, given 
      the difference in susceptibility and severity, the genetic factors may be 
      involved. Interleukin 6 (IL-6) and Matrix metalloproteinases 3 (MMP-3) were 
      previous found as key cytokines in the pathologies of adhesive capsulitis. The 
      present study aims to investigate whether variants within the IL-6 and MMP-3 gene 
      contributed to post-operative stiffness in a Chinese Han population. METHODS: A 
      total of 188 patients diagnosed with rotator cuff tears treated with mini-open 
      surgery were enrolled in this study, among which 87 patients were diagnosed as 
      post-operative stiffness and the remaining 101 patients as controls. All subjects 
      were genotyped for IL-6 and MMP-3 SNPs. RESULTS: The rs1800796 of IL-6 and 
      rs679620 of MMP-3 were found significantly associated with increased 
      susceptibility and severity of post-operative stiffness. CONCLUSION: The 
      rs1800796 SNP of IL-6 and rs650108 SNP of MMP-3 were associated with increased 
      risk of post-operative stiffness susceptibility and severity. This finding can be 
      used in guiding the rehabilitation procedure after rotator cuff surgery, in 
      another word, those with the genetic susceptibility factors should receive a more 
      radical rehabilitation procedure and those without the susceptibility factors can 
      be more conservative.
FAU - Ling, Yan
AU  - Ling Y
AD  - Department of Rehabilitation, Qilu Hospital, Shandong University, 44#, Wenhua Xi 
      Road Jinan, 250012, P.R. China ; Research Center of Sports Rehabilitation of 
      Shandong Jinan 250012, Shandong, China.
FAU - Peng, Cheng
AU  - Peng C
AD  - Department of General surgery, Qilu Hospital of Shandong University Jinan 250102, 
      Shandong, China.
FAU - Liu, Chenguang
AU  - Liu C
AD  - Research Center of Sports Rehabilitation of Shandong Jinan 250012, Shandong, 
      China.
FAU - Zhang, Na
AU  - Zhang N
AD  - Research Center of Sports Rehabilitation of Shandong Jinan 250012, Shandong, 
      China.
FAU - Yue, Shouwei
AU  - Yue S
AD  - Department of Rehabilitation, Qilu Hospital, Shandong University, 44#, Wenhua Xi 
      Road Jinan, 250012, P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20150501
PL  - United States
TA  - Int J Clin Exp Pathol
JT  - International journal of clinical and experimental pathology
JID - 101480565
RN  - 0 (IL6 protein, human)
RN  - 0 (Interleukin-6)
RN  - EC 3.4.24.17 (MMP3 protein, human)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Asian People/genetics
MH  - Case-Control Studies
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Interleukin-6/*genetics
MH  - Male
MH  - Matrix Metalloproteinase 3/*genetics
MH  - Middle Aged
MH  - Orthopedic Procedures/adverse effects
MH  - Polymorphism, Single Nucleotide
MH  - Postoperative Complications/*genetics/rehabilitation
MH  - Range of Motion, Articular/*genetics
MH  - Rotator Cuff/*surgery
PMC - PMC4503156
OTO - NOTNLM
OT  - IL-6
OT  - MMP-3
OT  - SNP
OT  - postoperative stiffness
EDAT- 2015/07/21 06:00
MHDA- 2016/04/19 06:00
PMCR- 2015/05/01
CRDT- 2015/07/21 06:00
PHST- 2015/02/03 00:00 [received]
PHST- 2015/03/30 00:00 [accepted]
PHST- 2015/07/21 06:00 [entrez]
PHST- 2015/07/21 06:00 [pubmed]
PHST- 2016/04/19 06:00 [medline]
PHST- 2015/05/01 00:00 [pmc-release]
PST - epublish
SO  - Int J Clin Exp Pathol. 2015 May 1;8(5):5709-14. eCollection 2015.