PMID- 26191657
OWN - NLM
STAT- MEDLINE
DCOM- 20160603
LR  - 20190221
IS  - 1532-0456 (Print)
IS  - 1532-0456 (Linking)
VI  - 176-177
DP  - 2015 Oct-Nov
TI  - In vivo induction of antioxidant response and oxidative stress associated with 
      genotoxicity and histopathological alteration in two commercial fish species due 
      to heavy metals exposure in northern India (Kali) river.
PG  - 17-30
LID - S1532-0456(15)00078-2 [pii]
LID - 10.1016/j.cbpc.2015.07.004 [doi]
AB  - Heavy metals can significantly bioaccumulate in fish tissues. The step wise 
      mechanism of heavy metal toxicities on fish health is still limited. The present 
      study assessed the tissue-specific antioxidant response and oxidative stress 
      biomarkers of commercially important fish species namely, Channa striatus and 
      Heteropneustes fossilis inhabiting Kali River of northern India where heavy-metal 
      load is beyond the World Health Organisation - maximum permissible limits. Heavy 
      metals chromium (Cr), nickel (Ni), lead (Pb) and cadmium (Cd) were elevated in 
      both fish species compared to recommended values of the Federal Environmental 
      Protection Agency (FEPA), 1999 for edible fishes. Reduced glutathione (GSH), 
      superoxide dismutase (SOD) and catalase (CATA) activities in all tissues 
      (brachial, neural, renal and hepatic) were altered. Cellular lipid and protein 
      compromisation in both fishes induced by heavy metals was determined by lipid 
      peroxidation (LPO) and protein carbonylation (PC) assays. Micronucleus (MN) test 
      of erythrocytes and comet assay of liver cells confirmed genotoxicity. 
      Histopathology of the liver, kidney and brain of affected fishes was distorted 
      significantly with its reference fishes thereby affecting the quality and 
      quantity of these fish stocks. This raises a serious concern as these fishes are 
      consumed by the local population which would ultimately affect human health.
CI  - Copyright (c) 2015. Published by Elsevier Inc.
FAU - Fatima, Mahino
AU  - Fatima M
AD  - Department of Zoology, Faculty of Life Sciences, Aligarh Muslim University, 
      Aligarh, 202002 U.P., India; Interdisciplinary Brain Research Centre, Faculty of 
      Medicine, Aligarh Muslim University, Aligarh, India. Electronic address: 
      lifesciencephd@gmail.com.
FAU - Usmani, Nazura
AU  - Usmani N
AD  - Department of Zoology, Faculty of Life Sciences, Aligarh Muslim University, 
      Aligarh, 202002 U.P., India.
FAU - Firdaus, Fakiha
AU  - Firdaus F
AD  - Department of Zoology, Faculty of Life Sciences, Aligarh Muslim University, 
      Aligarh, 202002 U.P., India; Interdisciplinary Brain Research Centre, Faculty of 
      Medicine, Aligarh Muslim University, Aligarh, India.
FAU - Zafeer, Mohammad Faraz
AU  - Zafeer MF
AD  - Interdisciplinary Brain Research Centre, Faculty of Medicine, Aligarh Muslim 
      University, Aligarh, India.
FAU - Ahmad, Shafeeque
AU  - Ahmad S
AD  - Department of Biochemistry, Jawaharlal Nehru Medical College, Faculty of 
      Medicine, Aligarh Muslim University, Aligarh, India.
FAU - Akhtar, Kafil
AU  - Akhtar K
AD  - Department of Pathology, Jawaharlal Nehru Medical College, Faculty of Medicine, 
      Aligarh Muslim University, Aligarh, India.
FAU - Dawar Husain, S M
AU  - Dawar Husain SM
AD  - Department of Anatomy, Jawaharlal Nehru Medical College, Faculty of Medicine, 
      Aligarh Muslim University, Aligarh, India.
FAU - Ahmad, Mir Hilal
AU  - Ahmad MH
AD  - Department of Zoology, Faculty of Life Sciences, Aligarh Muslim University, 
      Aligarh, 202002 U.P., India; Interdisciplinary Brain Research Centre, Faculty of 
      Medicine, Aligarh Muslim University, Aligarh, India.
FAU - Anis, Ehraz
AU  - Anis E
AD  - Interdisciplinary Brain Research Centre, Faculty of Medicine, Aligarh Muslim 
      University, Aligarh, India.
FAU - Mobarak Hossain, M
AU  - Mobarak Hossain M
AD  - Interdisciplinary Brain Research Centre, Faculty of Medicine, Aligarh Muslim 
      University, Aligarh, India.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150717
PL  - United States
TA  - Comp Biochem Physiol C Toxicol Pharmacol
JT  - Comparative biochemistry and physiology. Toxicology & pharmacology : CBP
JID - 100959500
RN  - 0 (Antioxidants)
RN  - 0 (Biomarkers)
RN  - 0 (Fish Proteins)
RN  - 0 (Metals, Heavy)
RN  - 0 (Water Pollutants, Chemical)
SB  - IM
MH  - Animals
MH  - Antioxidants/*metabolism
MH  - Biomarkers/metabolism
MH  - Body Burden
MH  - Brain/drug effects/metabolism/pathology
MH  - *Catfishes/genetics/metabolism
MH  - Comet Assay
MH  - DNA Damage
MH  - Environmental Monitoring/methods
MH  - Fish Proteins/genetics/metabolism
MH  - *Heavy Metal Poisoning
MH  - India
MH  - Kidney/drug effects/metabolism/pathology
MH  - Lipid Peroxidation/drug effects
MH  - Liver/drug effects/metabolism/pathology
MH  - Metals, Heavy/metabolism/*toxicity
MH  - Micronuclei, Chromosome-Defective/*chemically induced
MH  - Micronucleus Tests
MH  - Oxidative Stress/*drug effects
MH  - *Poisoning/genetics/metabolism/pathology
MH  - Protein Carbonylation/drug effects
MH  - Risk Assessment
MH  - Rivers
MH  - Water Pollutants, Chemical/metabolism/*toxicity
OTO - NOTNLM
OT  - Antioxidant response
OT  - Comet assay (CA)
OT  - Fishes
OT  - Heavy metals
OT  - Histopathology
OT  - Micronucleus (MN) test
EDAT- 2015/07/21 06:00
MHDA- 2016/06/04 06:00
CRDT- 2015/07/21 06:00
PHST- 2015/04/14 00:00 [received]
PHST- 2015/07/03 00:00 [revised]
PHST- 2015/07/08 00:00 [accepted]
PHST- 2015/07/21 06:00 [entrez]
PHST- 2015/07/21 06:00 [pubmed]
PHST- 2016/06/04 06:00 [medline]
AID - S1532-0456(15)00078-2 [pii]
AID - 10.1016/j.cbpc.2015.07.004 [doi]
PST - ppublish
SO  - Comp Biochem Physiol C Toxicol Pharmacol. 2015 Oct-Nov;176-177:17-30. doi: 
      10.1016/j.cbpc.2015.07.004. Epub 2015 Jul 17.