PMID- 26192093
OWN - NLM
STAT- MEDLINE
DCOM- 20160524
LR  - 20191210
IS  - 1873-7544 (Electronic)
IS  - 0306-4522 (Linking)
VI  - 304
DP  - 2015 Sep 24
TI  - Prenatal stress induces vulnerability to nicotine addiction and alters D2 
      receptors' expression in the nucleus accumbens in adult rats.
PG  - 279-85
LID - S0306-4522(15)00643-0 [pii]
LID - 10.1016/j.neuroscience.2015.07.029 [doi]
AB  - Prenatal stress (PS) can induce several long-lasting behavioral and molecular 
      abnormalities in rats. It can also be considered as a risk factor for many 
      psychiatric diseases like schizophrenia, depression or PTSD and predispose to 
      addiction. In this study, we investigated the effect of prenatal stress on the 
      reinforcing properties of nicotine in the CPP paradigm. Then, we examined the 
      mRNA expression of the D2 dopaminergic receptors using the quantitative real-time 
      PCR technique in the nucleus accumbens (NAcc). We found that prenatally stressed 
      rats exhibited a greater place preference for the nicotine-paired compartment 
      than the control rats. Moreover, we observed an overexpression of the DRD2 gene 
      in adult offspring stressed in utero and a downregulation in the PS NIC group (PS 
      rats treated with nicotine) compared with their control counterparts (C NIC). 
      These data suggest that maternal stress can permanently alter the offspring's 
      addictive behavior and D2 receptors' expression.
CI  - Copyright (c) 2015 IBRO. Published by Elsevier Ltd. All rights reserved.
FAU - Said, N
AU  - Said N
AD  - Laboratory of Pharmacology, Faculty of Medicine and Pharmacy of Casablanca, 19 
      Rue Tarik Bnou Ziad, Casablanca, Morocco. Electronic address: 
      s.nadia.10@hotmail.fr.
FAU - Lakehayli, S
AU  - Lakehayli S
AD  - Laboratory of Pharmacology, Faculty of Medicine and Pharmacy of Casablanca, 19 
      Rue Tarik Bnou Ziad, Casablanca, Morocco.
FAU - El Khachibi, M
AU  - El Khachibi M
AD  - Genetics and Molecular Pathology Laboratory, Faculty of Medicine and Pharmacy of 
      Casablanca, 19 Rue Tarik Bnou Ziad, Casablanca, Morocco.
FAU - El Ouahli, M
AU  - El Ouahli M
AD  - Sultan Moulay Slimane University, Faculty of Sciences & Techniques Beni-Mellal, 
      Life Sciences, Morocco.
FAU - Nadifi, S
AU  - Nadifi S
AD  - Genetics and Molecular Pathology Laboratory, Faculty of Medicine and Pharmacy of 
      Casablanca, 19 Rue Tarik Bnou Ziad, Casablanca, Morocco.
FAU - Hakkou, F
AU  - Hakkou F
AD  - Laboratory of Pharmacology, Faculty of Medicine and Pharmacy of Casablanca, 19 
      Rue Tarik Bnou Ziad, Casablanca, Morocco.
FAU - Tazi, A
AU  - Tazi A
AD  - Laboratory of Pharmacology, Faculty of Medicine and Pharmacy of Casablanca, 19 
      Rue Tarik Bnou Ziad, Casablanca, Morocco.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150717
PL  - United States
TA  - Neuroscience
JT  - Neuroscience
JID - 7605074
RN  - 0 (DRD2 protein, rat)
RN  - 0 (Nicotinic Agonists)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, Dopamine D2)
RN  - 6M3C89ZY6R (Nicotine)
SB  - IM
MH  - Animals
MH  - Conditioning, Psychological/drug effects/physiology
MH  - Disease Models, Animal
MH  - Female
MH  - Male
MH  - Nicotine/administration & dosage
MH  - Nicotinic Agonists/administration & dosage
MH  - Nucleus Accumbens/drug effects/growth & development/*metabolism
MH  - Polymerase Chain Reaction
MH  - Pregnancy
MH  - *Prenatal Exposure Delayed Effects
MH  - RNA, Messenger/metabolism
MH  - Rats, Wistar
MH  - Receptors, Dopamine D2/*metabolism
MH  - Spatial Behavior/drug effects/physiology
MH  - Stress, Psychological/*physiopathology
MH  - Tobacco Use Disorder/*physiopathology
OTO - NOTNLM
OT  - DRD2 mRNA expression
OT  - conditioned place preference
OT  - nicotine
OT  - nucleus accumbens
OT  - prenatal stress
OT  - qPCR
EDAT- 2015/07/21 06:00
MHDA- 2016/05/25 06:00
CRDT- 2015/07/21 06:00
PHST- 2015/03/09 00:00 [received]
PHST- 2015/06/22 00:00 [revised]
PHST- 2015/07/10 00:00 [accepted]
PHST- 2015/07/21 06:00 [entrez]
PHST- 2015/07/21 06:00 [pubmed]
PHST- 2016/05/25 06:00 [medline]
AID - S0306-4522(15)00643-0 [pii]
AID - 10.1016/j.neuroscience.2015.07.029 [doi]
PST - ppublish
SO  - Neuroscience. 2015 Sep 24;304:279-85. doi: 10.1016/j.neuroscience.2015.07.029. 
      Epub 2015 Jul 17.