PMID- 26193474
OWN - NLM
STAT- MEDLINE
DCOM- 20160428
LR  - 20181113
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 10
IP  - 7
DP  - 2015
TI  - The Ages and Stages Questionnaire and Neurodevelopmental Impairment in 
      Two-Year-Old Preterm-Born Children.
PG  - e0133087
LID - 10.1371/journal.pone.0133087 [doi]
LID - e0133087
AB  - OBJECTIVE: To test the ability of the Ages and Stages Questionnaire, Third 
      Edition (ASQ3) to help identify or exclude neurodevelopmental impairment (NDI) in 
      very preterm-born children at the corrected age of two. METHODS: We studied the 
      test results of 224 children, born at <32 postmenstrual weeks, who had scores on 
      ASQ3 and Bayley Scales of Infant and Toddler Development, Third Edition (BSIDIII) 
      and neurological examination at 22-26 months' corrected age. We defined NDI as a 
      score of <70 on the cognitive--or motor composite scale of BSIDIII, or impairment 
      on neurological examination or audiovisual screening. We compared NDI with 
      abnormal ASQ3 scores, i.e., < -2SDs on any domain, and with ASQ3 total scores. To 
      correct for possible overestimation of BSIDIII, we also analyzed the adjusted 
      BSIDIII thresholds for NDI, i.e., scores <80 and <85. RESULTS: We found 61 (27%) 
      children with abnormal ASQ3 scores, and 10 (4.5%) children who had NDI with 
      original BSIDIII thresholds (<70). Twelve children had NDI at BSIDIII thresholds 
      at <80, and 15 had <85. None of the 163 (73%) children who passed ASQ3 had NDI. 
      The sensitivity of ASQ3 to detect NDI was excellent (100%), its specificity was 
      acceptable (76%), and its negative predictive value (NPV) was 100%. Sensitivity 
      and NPV remained high with the adjusted BSIDIII thresholds. CONCLUSION: The Ages 
      and Stages Questionnaire is a simple, valid and cost-effective screening tool to 
      help identify and exclude NDI in very preterm-born children at the corrected age 
      of two years.
FAU - Kerstjens, Jorien M
AU  - Kerstjens JM
AD  - Division of Neonatology, Department of Pediatrics, Beatrix Children's Hospital, 
      University Medical Center Groningen, Groningen, The Netherlands.
FAU - Nijhuis, Ard
AU  - Nijhuis A
AD  - Division of Neonatology, Department of Pediatrics, Beatrix Children's Hospital, 
      University Medical Center Groningen, Groningen, The Netherlands.
FAU - Hulzebos, Christian V
AU  - Hulzebos CV
AD  - Division of Neonatology, Department of Pediatrics, Beatrix Children's Hospital, 
      University Medical Center Groningen, Groningen, The Netherlands.
FAU - van Imhoff, Deirdre E
AU  - van Imhoff DE
AD  - Division of Neonatology, Department of Pediatrics, Beatrix Children's Hospital, 
      University Medical Center Groningen, Groningen, The Netherlands.
FAU - van Wassenaer-Leemhuis, Aleid G
AU  - van Wassenaer-Leemhuis AG
AD  - Department of Neonatology, Emma Children's Hospital Academic Medical Center, 
      Amsterdam, The Netherlands.
FAU - van Haastert, Ingrid C
AU  - van Haastert IC
AD  - Department of Neonatology, Wilhelmina Children's Hospital/University Medical 
      Center Utrecht, Utrecht, The Netherlands.
FAU - Lopriore, Enrico
AU  - Lopriore E
AD  - Division of Neonatology, Department of Pediatrics, Leiden University Medical 
      Center, Leiden, The Netherlands.
FAU - Katgert, Titia
AU  - Katgert T
AD  - Department of Medical Psychology, Maxima Medical Center, Veldhoven, The 
      Netherlands.
FAU - Swarte, Renate M
AU  - Swarte RM
AD  - Department of Neonatology, Erasmus MC-Sophia, Rotterdam, The Netherlands.
FAU - van Lingen, Richard A
AU  - van Lingen RA
AD  - Princess Amalia Department of Pediatrics, Department of Neonatology, Isala, 
      Zwolle, The Netherlands.
FAU - Mulder, Twan L
AU  - Mulder TL
AD  - Department of Pediatrics, Maastricht University Medical Center, GROW-School for 
      Oncology and Developmental Biology, Maastricht, The Netherlands.
FAU - Laarman, Celeste R
AU  - Laarman CR
AD  - Division of Neonatology, Department of Pediatrics, VU University Medical Center, 
      Amsterdam, The Netherlands.
FAU - Steiner, Katerina
AU  - Steiner K
AD  - Division of Neonatology, Department of Pediatrics, Radboud University Medical 
      Centre Nijmegen, Nijmegen, The Netherlands.
FAU - Dijk, Peter H
AU  - Dijk PH
AD  - Division of Neonatology, Department of Pediatrics, Beatrix Children's Hospital, 
      University Medical Center Groningen, Groningen, The Netherlands.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150720
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Area Under Curve
MH  - Birth Weight
MH  - Child Development
MH  - Child, Preschool
MH  - Developmental Disabilities/*diagnosis
MH  - Female
MH  - Gestational Age
MH  - Humans
MH  - Infant
MH  - Infant, Premature
MH  - Male
MH  - *Neurologic Examination
MH  - Neurons/*physiology
MH  - ROC Curve
MH  - Surveys and Questionnaires
PMC - PMC4508030
COIS- Competing Interests: The authors have declared that no competing interests 
      exists.
EDAT- 2015/07/21 06:00
MHDA- 2016/04/29 06:00
PMCR- 2015/07/20
CRDT- 2015/07/21 06:00
PHST- 2015/02/18 00:00 [received]
PHST- 2015/06/22 00:00 [accepted]
PHST- 2015/07/21 06:00 [entrez]
PHST- 2015/07/21 06:00 [pubmed]
PHST- 2016/04/29 06:00 [medline]
PHST- 2015/07/20 00:00 [pmc-release]
AID - PONE-D-15-07564 [pii]
AID - 10.1371/journal.pone.0133087 [doi]
PST - epublish
SO  - PLoS One. 2015 Jul 20;10(7):e0133087. doi: 10.1371/journal.pone.0133087. 
      eCollection 2015.