PMID- 26193909 OWN - NLM STAT- MEDLINE DCOM- 20161018 LR - 20170103 IS - 1747-0803 (Electronic) IS - 1747-079X (Linking) VI - 10 IP - 6 DP - 2015 Nov-Dec TI - Distribution of Hypertrophy and Late Gadolinium Enhancement in Children and Adolescents with Hypertrophic Cardiomyopathy. PG - E258-67 LID - 10.1111/chd.12286 [doi] AB - BACKGROUND: While well characterized in adult patients, the pattern of hypertrophy and the extent of myocardial scarring in hypertrophic cardiomyopathy (HCM) are insufficiently known. The aim of this study was to assess the hypertrophy patterns and the prevalence and clinical significance of scars in the hearts of young patients with HCM. METHODS AND RESULTS: A retrospective analysis of the imaging findings of 38 children (aged 12.83 +/- 2 years, 30 males) with HCM who underwent cardiac magnetic resonance imaging (CMR) was performed. In addition to left ventricular mass and volumes, the examinations were assessed for the pattern of hypertrophy and presence of late gadolinium enhancement (LGE). A myocardial signal intensity >/=6 standard deviations above the mean of normal myocardium defined positive LGE. Left ventricular mass index averaged 110 +/- 34 g/m(2) . Nineteen children (50%) had diffuse septal, 13 (34%) diffuse concentric and 6 (16%) isolated basal hypertrophy. Seven children (18%) had LGE. Patients with LGE had a greater left ventricular mass index than those without (136 +/- 34 g/m(2) vs. 104 +/- 31 g/m(2) , P = .025). The only two patients who presented with an episode of aborted sudden cardiac death had LGE (P = .03). CONCLUSIONS: The most common hypertrophy pattern in children with HCM was diffuse septal hypertrophy. The incidence of LGE observed is lower than that reported in adults. The presence of LGE appears to confer a risk for adverse events. CI - (c) 2015 Wiley Periodicals, Inc. FAU - Windram, Jonathan D AU - Windram JD AD - Department of Diagnostic Imaging, Division of Cardiology, The Labatt Family Heart Centre, The Hospital for Sick Children, University of Toronto School of Medicine, Toronto, ON, Canada. AD - Department of Paediatrics, Division of Cardiology, The Labatt Family Heart Centre, The Hospital for Sick Children, University of Toronto School of Medicine, Toronto, ON, Canada. FAU - Benson, Lee N AU - Benson LN AD - Department of Paediatrics, Division of Cardiology, The Labatt Family Heart Centre, The Hospital for Sick Children, University of Toronto School of Medicine, Toronto, ON, Canada. FAU - Dragelescu, Andreea AU - Dragelescu A AD - Department of Paediatrics, Division of Cardiology, The Labatt Family Heart Centre, The Hospital for Sick Children, University of Toronto School of Medicine, Toronto, ON, Canada. FAU - Yoo, Shi-Joon AU - Yoo SJ AD - Department of Diagnostic Imaging, Division of Cardiology, The Labatt Family Heart Centre, The Hospital for Sick Children, University of Toronto School of Medicine, Toronto, ON, Canada. AD - Department of Paediatrics, Division of Cardiology, The Labatt Family Heart Centre, The Hospital for Sick Children, University of Toronto School of Medicine, Toronto, ON, Canada. FAU - Mertens, Luc AU - Mertens L AD - Department of Paediatrics, Division of Cardiology, The Labatt Family Heart Centre, The Hospital for Sick Children, University of Toronto School of Medicine, Toronto, ON, Canada. FAU - Wong, Derek AU - Wong D AD - Department of Diagnostic Imaging, Division of Cardiology, The Labatt Family Heart Centre, The Hospital for Sick Children, University of Toronto School of Medicine, Toronto, ON, Canada. AD - Department of Paediatrics, Division of Cardiology, The Labatt Family Heart Centre, The Hospital for Sick Children, University of Toronto School of Medicine, Toronto, ON, Canada. FAU - Grosse-Wortmann, Lars AU - Grosse-Wortmann L AD - Department of Diagnostic Imaging, Division of Cardiology, The Labatt Family Heart Centre, The Hospital for Sick Children, University of Toronto School of Medicine, Toronto, ON, Canada. AD - Department of Paediatrics, Division of Cardiology, The Labatt Family Heart Centre, The Hospital for Sick Children, University of Toronto School of Medicine, Toronto, ON, Canada. LA - eng PT - Journal Article PT - Observational Study PT - Research Support, Non-U.S. Gov't DEP - 20150720 PL - United States TA - Congenit Heart Dis JT - Congenital heart disease JID - 101256510 RN - 0 (Contrast Media) RN - K2I13DR72L (Gadolinium DTPA) SB - IM MH - Adolescent MH - Cardiomyopathy, Hypertrophic/*diagnosis/epidemiology/physiopathology MH - Child MH - Contrast Media/pharmacology MH - Female MH - Follow-Up Studies MH - Gadolinium DTPA/*pharmacology MH - Heart Ventricles/diagnostic imaging/*pathology/physiopathology MH - Humans MH - Magnetic Resonance Imaging, Cine/*methods MH - Male MH - Myocardium/*pathology MH - Ontario/epidemiology MH - Prevalence MH - Retrospective Studies MH - Ultrasonography MH - Ventricular Function, Left/*physiology OTO - NOTNLM OT - Cardiac Magnetic Resonance Imaging OT - Echocardiography OT - Gadolinium Delayed Enhancement OT - Hypertrophic Cardiomyopathy EDAT- 2015/07/22 06:00 MHDA- 2016/10/19 06:00 CRDT- 2015/07/22 06:00 PHST- 2015/06/06 00:00 [accepted] PHST- 2015/07/22 06:00 [entrez] PHST- 2015/07/22 06:00 [pubmed] PHST- 2016/10/19 06:00 [medline] AID - 10.1111/chd.12286 [doi] PST - ppublish SO - Congenit Heart Dis. 2015 Nov-Dec;10(6):E258-67. doi: 10.1111/chd.12286. Epub 2015 Jul 20.