PMID- 26194242
OWN - NLM
STAT- MEDLINE
DCOM- 20181211
LR  - 20181211
IS  - 1614-7499 (Electronic)
IS  - 0944-1344 (Print)
IS  - 0944-1344 (Linking)
VI  - 25
IP  - 8
DP  - 2018 Mar
TI  - Selective and comprehensive analysis of organohalogen compounds by 
      GC x GC-HRTofMS and MS/MS.
PG  - 7135-7146
LID - 10.1007/s11356-015-5059-5 [doi]
AB  - Thousands of organohalogen compounds, including hazardous chemicals such as 
      polychlorinated biphenyls (PCBs) and other persistent organic pollutants (POPs), 
      were selectively and simultaneously detected and identified with simple, or no, 
      purification from environmental sample extracts by using several advanced 
      methods. The methods used were software extraction from two-dimensional gas 
      chromatography-high-resolution time-of-flight mass spectrometry (GC x GC-HRTofMS) 
      data, measurement by negative chemical ionization with HRTofMS, and neutral loss 
      scanning (NLS) with GC x GC-MS/MS. Global and selective detection of 
      organochlorines and bromines in environmental samples such as sediments and fly 
      ash was achieved by NLS using GC x GC-MS/MS (QQQ), with the expected losses of 
      (35)Cl and (79)Br. We confirmed that negative chemical ionization was effective 
      for sensitive and selective ionization of organohalogens, even using 
      GC x GC-HRTofMS. The 2D total ion chromatograms obtained by using negative 
      chemical ionization and selective extraction of organohalogens using original 
      software from data measured by electron impact ionization were very similar; the 
      software thus functioned well to extract organohalogens. Combining measurements 
      made by using these different methods will help to detect organohalogens 
      selectively and globally. However, to compare the data obtained by individual 
      measurements, the retention times of the peaks on the 2D chromatograms need to 
      match.
FAU - Hashimoto, Shunji
AU  - Hashimoto S
AD  - National Institute for Environmental Studies, Onogawa 16-2, Tsukuba, 305-8506, 
      Japan. shunji@nies.go.jp.
FAU - Zushi, Yasuyuki
AU  - Zushi Y
AD  - National Institute for Environmental Studies, Onogawa 16-2, Tsukuba, 305-8506, 
      Japan.
AD  - Advanced Industrial Science and Technology, Onogawa 16-1, Tsukuba, 305-8569, 
      Japan.
FAU - Takazawa, Yoshikatsu
AU  - Takazawa Y
AD  - National Institute for Environmental Studies, Onogawa 16-2, Tsukuba, 305-8506, 
      Japan.
FAU - Ieda, Teruyo
AU  - Ieda T
AD  - National Institute for Environmental Studies, Onogawa 16-2, Tsukuba, 305-8506, 
      Japan.
FAU - Fushimi, Akihiro
AU  - Fushimi A
AD  - National Institute for Environmental Studies, Onogawa 16-2, Tsukuba, 305-8506, 
      Japan.
FAU - Tanabe, Kiyoshi
AU  - Tanabe K
AD  - National Institute for Environmental Studies, Onogawa 16-2, Tsukuba, 305-8506, 
      Japan.
FAU - Shibata, Yasuyuki
AU  - Shibata Y
AD  - National Institute for Environmental Studies, Onogawa 16-2, Tsukuba, 305-8506, 
      Japan.
LA  - eng
PT  - Journal Article
DEP - 20150722
PL  - Germany
TA  - Environ Sci Pollut Res Int
JT  - Environmental science and pollution research international
JID - 9441769
RN  - 0 (Environmental Pollutants)
RN  - 0 (Hydrocarbons, Halogenated)
SB  - IM
MH  - Data Mining
MH  - Environmental Monitoring/*methods
MH  - Environmental Pollutants/*analysis/chemistry
MH  - *Gas Chromatography-Mass Spectrometry
MH  - Hydrocarbons, Halogenated/*analysis/chemistry
MH  - Software
MH  - *Tandem Mass Spectrometry
MH  - Time Factors
PMC - PMC5847631
OTO - NOTNLM
OT  - Mass defect
OT  - Multidimensional data analysis
OT  - Neutral loss
OT  - Non-target analysis
OT  - Software extraction and cleanup
EDAT- 2015/07/22 06:00
MHDA- 2018/12/12 06:00
PMCR- 2015/07/22
CRDT- 2015/07/22 06:00
PHST- 2015/03/12 00:00 [received]
PHST- 2015/07/09 00:00 [accepted]
PHST- 2015/07/22 06:00 [pubmed]
PHST- 2018/12/12 06:00 [medline]
PHST- 2015/07/22 06:00 [entrez]
PHST- 2015/07/22 00:00 [pmc-release]
AID - 10.1007/s11356-015-5059-5 [pii]
AID - 5059 [pii]
AID - 10.1007/s11356-015-5059-5 [doi]
PST - ppublish
SO  - Environ Sci Pollut Res Int. 2018 Mar;25(8):7135-7146. doi: 
      10.1007/s11356-015-5059-5. Epub 2015 Jul 22.